Abstract
The scrotum is a specialised, low-temperature environment which allows optimal postnatal development of the gonocytes and postpubertal spermatogenesis. The temperature of the scrotum is 33 °C, which means that intraabdominal testes are 4 °C away from optimal physiology and intracellular functioning, which is the likely reason for secondary dysplasia. Temperature-dependent dysgenesis is proposed to cause progressive loss of the spermatogonia, leading to subsequent poor sperm counts, while any residual gonocytes might eventually mutate into a seminoma. Successful surgical placement of the testis into the scrotum is dependent not only on the assumption that the damage is secondary rather than a primary disorder of the testis, but also that early intervention can prevent and/or reverse this. Additionally orchidopexy aims to overcome the cosmetic deformity.
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Ong C, Hasthorpe S, Hutson JM. Germ cell development in the descended and cryptorchid testis and the effects of hormonal manipulation. Pediatr Surg Int. 2005;21(4):240–54.
John Radcliffe Hospital Cryptorchidism Study Group. An apparent substantial increase since 1960. BMJ 293:1401.
John Radcliffe Hospital Cryptorchidism Study Group. Boys with late ascending testes: the source of patients with “retractile” testes undergoing orchidopexy. BMJ. 1986;293:789.
Clarnette TD, Lam SK, Hutson JM. Ventriculo-peritoneal shunts in children reveal the natural history of closure of the processus vaginalis. J Pediatr Surg. 1998;33(3):413–6.
Gendrel D, Roger M, Job JC. Plasma gonadotropin and testosterone values in infants with cryptorchidism. J Pediatr. 1980;97(2):217–20.
Hadziselimovic F. Cryptorchidism: management and implications. In: Hadziselimovic F, editor. Berlin: Springer; 1983.
Kaiserman KB, Nakamoto JM, Geffner ME, et al. Minipuberty of infancy and adolescent pubertal function in adrenal hypoplasia congenita. J Pediatr. 1998;133(2):300–2.
Baker M, Metcalfe S, Hutson J. Serum levels of Mullerian inhibiting substance in boys from birth to 18 years, as determined by enzyme immunoassay. J Clin Endocrinol Metab. 1990;70:11–5.
Baker ML, Hutson JM. Serum levels of Mullerian inhibiting substance in boys throughout puberty and in the first two years of life. J Clin Endocrinol Metab. 1993;76(1):245–7.
Hadziselimovic F, Hocht B, Herzog B. Infertility in cryptorchidism is linked to the stage of germ cell development at orchidopexy. Horm Res. 2007;68(1):46–52.
Zhou B, Watts LM, Hutson JM. Germ cell development in neonatal mouse testes in vitro requires Mullerian inhibiting substance. J Urol. 1993;150(2 Pt 2):613–6.
Huff DS, Hadziselimovic F, Snyder HM 3rd, et al. Histologic maldevelopment of unilaterally cryptorchid testes and their descended partners. Eur J Pediatr. 1993;152(Suppl 2):S11–4.
Huff DS, Hadziselimovic F, Snyder HM 3rd, et al. Postnatal testicular maldevelopment in unilateral cryptorchidism. J Urol 1989;142(2 Pt 2):546–8; discussion 572.
Huff DS, Wu HY, Snyder HM 3rd, et al. Evidence in favor of the mechanical (intrauterine torsion) theory over the endocrinopathy (cryptorchidism) theory in the pathogenesis of testicular agenesis. J Urol 1991;146(2 Pt 2):630–1.
Farrer JH, Sikka SC, Xie HW, et al. Impaired testosterone biosynthesis in cryptorchidism. Fertil Steril. 1985;44(1):125–32.
Yamanaka J, Baker M, Metcalfe S, et al. Serum levels of Mullerian inhibiting substance in boys with cryptorchidism. J Pediatr Surg. 1991;26(5):621–3.
Hadziselimovic F, Huff D. Gonadal differentiation–normal and abnormal testicular development. Adv Exp Med Biol 2002;511:15–21; discussion 21–3.
Huff DS, Fenig DM, Canning DA, et al. Abnormal germ cell development in cryptorchidism. Horm Res. 2001;55(1):11–7.
Mieusset R, Fonda P, Vaysse P, et al. Increase in testicular temperature in case of cryptorchidism in boys. Fertil Steril. 1993;59:1319–21.
Jorgensen N, Rajpert-De Meyts E, Graem N, et al. Expression of immunohistochemical markers for testicular carcinoma in situ by normal human fetal germ cells. Lab Invest. 1995;72(2):223–31.
Giwercman A, Grindsted J, Hansen B, et al. Testicular cancer risk in boys with maldescended testis: a cohort study. J Urol. 1987;138(5):1214–6.
Giwercman A, Muller J, Skakkebaek NE. Carcinoma in situ of the testis: possible origin, clinical significance, and diagnostic methods. Recent Results Cancer Res. 1991;123:21–36.
Giwercman A, Muller J, Skakkeboek NE. Cryptorchidism and testicular neoplasia. Horm Res. 1988;30(4–5):157–63.
Pettersson A, Richiardi L, Nordenskjold A, et al. Age at surgery for undescended testis and risk of testicular cancer. N Engl J Med. 2007;356(18):1835–41.
Ritzen EM, Kollin C. Management of undescended testes: how and when? Pediatr Endocrinol Rev. 2009;7(1):32–7.
Thorup J, Cortes D. Surgical treatment and follow up on undescended testis. Pediatr Endocrinol Rev. 2009;7(1):38–43.
Kollin C, Karpe B, Hesser U, et al. Surgical treatment of unilaterally undescended testes: testicular growth after randomization to orchiopexy at age 9 months or 3 years. J Urol 2007;178(4 Pt 2):1589–93; discussion 1593.
Myers NA, Officer CB. Undescended testes: congenital or acquired? Aust Paediatr J 1975;11:76–80.
Clarnette TD, Hutson JM. Is the ascending testis actually ‘stationary’? Normal elongation of the spermatic cord is prevented by a fibrous remnant of the processus vaginalis. Pediatr Surg Int. 1997;12(2/3):155–7.
Clarnette TD, Rowe D, Hasthorpe S, et al. Incomplete disappearance of the processus vaginalis as a cause of ascending testis. J Urol. 1997;157(5):1889–91.
Fenton E, Woodward A, Hutson J. The ascending testis. Pediatr Surg Int. 1990;5:6–9.
Smith A, Hutson JM, Beasley SW, Reddihough DS. The relationship between cerebral palsy and cryptorchidism. J Pediatr Surg. 1989;24(12)
Guven A, Kogan BA. Undescended testis in older boys: further evidence that ascending testes are common. J Pediatr Surg. 2008;43(9):1700–4.
Donaldson KM, Tong SY, Hutson JM. Prevalence of late orchidopexy is consistent with some undescended testes being acquired. Indian J Pediatr. 1996;63(6):725–9.
Agarwal PK, Diaz M, Elder JS. Retractile testis–is it really a normal variant? J Urol. 2006;175(4):1496–9.
Hack WW, Sijstermans K, van der Voort-Doedens LM, et al. The high scrotal (“gliding”) testis revised. Eur J Pediatr. 2007;166(1):57–61.
Redman JF. The ascending (acquired undescended) testis: a phenomenon? BJU Int. 2005;95(9):1165–7.
Cortes D, Thorup JM, Visfeldt J. Cryptorchidism: aspects of fertility and neoplasms. A study including data of 1335 consecutive boys who underwent testicular biopsy simultaneously with surgery for cryptorchidism. Horm Res. 2001;55(1):21–7.
Zorgniotti A. Temperature and environmental effects on the testis. Adv Exp Med Biol. 1991;286:1–335.
deMuinck Keizer-Schrama SMPF, Hazebroek FW, Matroos AW, et al. Double-blind, placebo-controlled study of luteinising-hormone-releasing-hormone nasal spray in treatment of undescended testes. Lancet. 1986;1(8486):876–80.
Hadziselimovic F. Successful treatment of unilateral cryptorchid boys risking infertility with LH-RH analogue. Int Braz J Urol 2008;34(3):319–26; discussion 327–8.
Ritzen EM, Bergh A, Bjerknes R, et al. Nordic consensus on treatment of undescended testes. Acta Paediatr. 2007;96(5):638–43.
Thorsson AV, Christiansen P, Ritzen M. Efficacy and safety of hormonal treatment of cryptorchidism: current state of the art. Acta Paediatr. 2007;96(5):628–30.
Hutson JM, Balic A, Nation T, et al. Cryptorchidism. Semin Pediatr Surg. 2010;19(3):215–24.
Bianchi A, Squire B. Trans-scrotal orchidopexy: orchidopexy revisited. Pediatr Surg Int. 1989;4:189.
Fowler R, Stephens FD. The role of testicular vascular anatomy in the salvage of high undescended testes. Aust N Z J Surg. 1959;29:92–106.
Papparella A, Parmeggiani P, Cobellis G, et al. Laparoscopic management of nonpalpable testes: a multicenter study of the Italian Society of Video Surgery in Infancy. J Pediatr Surg. 2005;40(4):696–700.
Wilson-Storey D, McGenity K, Dickson JA. Orchidopexy: the younger the better? J R Coll Surg Edinb. 1990;35(6):362–4.
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Hutson, J. (2018). Surgical Considerations of Testicular Maldescent. In: Ledbetter, D., Johnson, P. (eds) Endocrine Surgery in Children. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54256-9_20
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