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Chronic Self-Stimulation of the Dentate Nucleus for the Relief of Spasticity

  • Conference paper
Advances in Stereotactic and Functional Neurosurgery 4

Part of the book series: Acta Neurochirurgica Supplementum ((STEREOTACTIC,volume 30))

Summary

It has been assumed but not yet proved that cerebellar cortical Stimulation activates the Purkinje cells, with subsequent inhibition of the deep cerebellar nuclei. However, the relatively crude, widespread excitation induced by several surface electrode arrays and the parameters of Stimulation currently used, may produce other effects than selective activation of only one specific cellular type which, furthermore, seems to be rarely present in these particular patients, as demonstrated by biopsy studies prior to electrode placement.

The dentate nucleus was chronically implanted with a stimulating system in a patient with spasticity due to cerebral palsy. Chronic self-stimulation induced a significant improvement in motor function, with relief of spasticity and improvement in speech, posture, balance and gait. Electrophysiological studies demonstrated a decrease in the amplitude of V1 and V2 responses and in the H/M and T/M ratios, an increase in the silent period, and marked effects in the H reflex recovery curve, as well as diminished contralateral cortical somato-sensory evoked potentials. This result seems to indicate that the clinical effects of cerebellar cortical Stimulation are not due to prosthetically induced inhibition of the dentate nucleus.

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Authors and Affiliations

  1. Institute of Neurosurgery, School of Medicine, University of Buenos Aires, Beruti 2926, Buenos Aires 1425, Argentina

    J. R. Schvarcz

Authors
  1. J. R. Schvarcz
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  2. R. E. Sica
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  3. E. Morita
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Editor information

Editors and Affiliations

  1. Western General Hospital and Royal Infirmary, University of Edinburgh, Edinburgh, UK

    F. John Gillingham (Professor of Neurosurgery) (Professor of Neurosurgery)

  2. Academisch Ziekenhuis, Leuven, Belgium

    Jan Gybels (Professor of Neurosurgery) (Professor of Neurosurgery)

  3. Midland Center for Neurosurgery and Neurology and Queen Elizabeth Hospital, University of Birmingham, Birmingham, UK

    Edward Hitchcock (Professor of Neurosurgery) (Professor of Neurosurgery)

  4. Istituto di Neurochirurgia, Università Cattolica del Sacro Cuore, Roma, Italy

    Gian Franco Rossi (Professor of Neurosurgery) (Professor of Neurosurgery)

  5. Service de Neurochirurgie Fonctionnelle, Centre Hospitalier Sainte Anne, Paris, France

    Gábor Szikla (Maître de Recherche C.N.R.S., Neurosurgeon) (Maître de Recherche C.N.R.S., Neurosurgeon)

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© 1980 Springer-Verlag

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Schvarcz, J.R., Sica, R.E., Morita, E. (1980). Chronic Self-Stimulation of the Dentate Nucleus for the Relief of Spasticity. In: Gillingham, F.J., Gybels, J., Hitchcock, E., Rossi, G.F., Szikla, G. (eds) Advances in Stereotactic and Functional Neurosurgery 4. Acta Neurochirurgica Supplementum, vol 30. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8592-6_43

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  • DOI: https://doi.org/10.1007/978-3-7091-8592-6_43

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-81591-5

  • Online ISBN: 978-3-7091-8592-6

  • eBook Packages: Springer Book Archive

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