Abstract
Digital Microfluidic Biochip (DMFB) is revolutionizing many areas of Microelectronics, Biochemistry, and Biomedical sciences. It is also known as ‘Lab-on-a-Chip’ for its popularity as an alternative for laboratory experiments. The mixing of samples and reagents for a biological or chemical lab-on-a-chip is important, yet difficult, in microfluidic operations. As volume is of the order of sub-nanoliter, the mixing of liquids is hindered by laminar flow conditions. The fixed geometric parameters of the mixer and the type of movement of the coalesced droplet control droplet mixing time. In this paper, we study the effects of varying mixer sizes and propose of mixing strategies applicable to some Polymerase Chain Reaction (PCR) where a series of mixing is required. A design of mixer has been proposed including its pin assignment where reduction of time of mixing is a key challenging issue to enhance the performance of the chip in terms of throughput.
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References
Chakrabarty, K., Xu, T.: Digital Microfluidic Biochips Design Automation and Optimization. CRC Press, Boca Raton (2010)
Xu, T., Chakrabarty, K.: Droplet-trace-based array partitioning and a pin assignment algorithm for the automated design of digital microfluidic biochips. IEEE/ACM ICH/SCSS, pp. 112–117 (2006)
Fair, R.B.: Digital microfluidics: is a true lab-on-a-chip possible? Microfluid. Nanofluid. 3, 245–281 (2007)
Fair, R.B., Srinivasan, V., Ren, H., Paik, P., Pamula, V., Pollack, M.G.: Electrowetting based on chip sample processing for integrated microfluidics. IEDM, pp. 779–782 (2003)
Paik, P., Pamula, V.K., Fair, R.B.: Rapid droplet mixers for digital microfluidic systems. Lab Chip 3, 253–259 (2003)
Paik, P., Pamula, V.K., Pollack, M.G., Fair, R.B.: Electrowetting based droplet mixers for microfluidic systems. Lab Chip 3, 28–33 (2003)
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© 2015 Springer India
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Dhal, D., Datta, P., Chakraborty, A., Pal, R.K. (2015). Design of a Mixer for Performing Efficient Mixing to Reduce Overall Assay Response Time. In: Mandal, J., Satapathy, S., Kumar Sanyal, M., Sarkar, P., Mukhopadhyay, A. (eds) Information Systems Design and Intelligent Applications. Advances in Intelligent Systems and Computing, vol 340. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2247-7_57
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DOI: https://doi.org/10.1007/978-81-322-2247-7_57
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