Abstract
It has been well established that the calcitonin receptor (CTR) mediates the actions of calcitonin in bone homeostatic mechanisms during growth and in adulthood. However, the widespread expression of CTR in embryonic, foetal and adult tissues together with functional studies implicates the activity of CTR in other physiological and pathophysiological events including wound healing, cardiovascular disease and some cancers. The development of high affinity anti-CTR antibodies has helped define the roles of CTR in organogenesis and pathogenesis, and has focused our attention on the roles of precursor cells that express CTR. These CTR-positive cells are featured in foetal development, cardiovascular disease and leukaemia. It is hypothesised that the potential to express CTR is a fundamental property of precursors and progeny of the haematopoietic lineages.
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- AGM:
-
Aorta-gonado-mesonephros
- ALL:
-
Acute lymphoblastic leukaemia
- AM:
-
Adrenomedullin
- AML:
-
Acute myeloblastic leukaemia
- CD34:
-
Cluster of differentiation antigen 34
- CGRP:
-
Calcitonin gene-related peptide
- CLR:
-
Calcitonin receptor-like receptor
- CNS:
-
Central nervous system
- CT:
-
Calcitonin
- hCT:
-
Rhuman calcitonin receptor
- CTR-ir:
-
CTR immuno-reactivity
- CVD:
-
Cardiovascular disease
- ELISA:
-
Enzyme-linked immunosorbant assay
- FACS:
-
Fluorescence activated cell sorting
- Gb R:
-
Gamma amino butyric acid receptor
- GDNF:
-
glial cell-derived neurotrophic factor
- GFAP:
-
Glial fibrilliary acidic protein
- GFR:
-
GDNF-family receptor
- GPCR:
-
G-protein coupled receptors
- HMEC:
-
Human microvessel endothelial cells
- IF:
-
Immunofluorescence
- IHC:
-
Immunohistochemistry
- ISH:
-
In situ hybridization
- [125I]-sCT:
-
[125I]-iodine labeled salmon calcitonin
- MAb:
-
Monoclonal antibody
- NFkappaβ:
-
Transcription factor
- PAb:
-
Polyclonal antibody
- PACAP:
-
Pituitary adenylyl cyclase activating peptide
- PAC 1:
-
PACAP selective receptor
- PCR:
-
Polymerase chain reaction
- PNS:
-
Peripheral nervous system
- PTH:
-
Parathyroid hormone
- RAMP:
-
Receptor activity modifying protein
- RANK:
-
Receptor activator of NFkappaβ
- RANKL:
-
RANK ligand
- RET:
-
(RE-arranged during Transfection) receptor tyrosine kinase
- VEGFR:
-
Vascular epithelial growth factor receptor
- VIP:
-
Vasoactive intestinal peptide
- VPAC R:
-
VIP/PACAP receptor
- WB:
-
Western blot
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Wookey, P. et al. (2010). Calcitonin Receptor Expression in Embryonic, Foetal and Adult Tissues: Developmental and Pathophysiological Implications. In: Hay, D., Dickerson, I. (eds) The calcitonin gene-related peptide family. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2909-6_13
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