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Stem Cells and Cancer Stem Cells, Volume 2 pp 269–275Cite as

Generating Human Cardiac Muscle Cells from Adipose-Derived Stem Cells

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Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 2))

Abstract

Therapies using stem cells and tissue engineering for cardiovascular regeneration aim to repair damaged cardiac tissue by delivering stem cells with biomaterials and biomolecules to support cell survival and differentiation. When implanted in undifferentiated states, stem cells recognize the cues around them to adopt a variety of cell fates. However, disease processes (e.g., myocardial infarcts) alter the microenvironment, and differentiation is often misdirected. For this reason it is best to differentiate stem cells into cardiomyocyte specific lineages in vitro prior to implantation. Stem cells can form mature cardiac muscle cells by employing various differentiation methods, including epigenetic modification, differentiation media, and co-culture with neonatal cardiomyocytes. Here we discuss adipose tissue-derived stem cells and how they may be directed into cardiomyocytes for tissue engineering.

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Authors and Affiliations

  1. O’Brien Institute, Fitzroy, VIC, 065, Australia

    Rodney Dilley, Yu Suk Choi & Gregory Dusting

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  1. Rodney Dilley
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  2. Yu Suk Choi
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  3. Gregory Dusting
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Corresponding author

Correspondence to Rodney Dilley .

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Editors and Affiliations

  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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© 2012 Springer Science+Business Media B.V.

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Dilley, R., Choi, Y.S., Dusting, G. (2012). Generating Human Cardiac Muscle Cells from Adipose-Derived Stem Cells. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 2. Stem Cells and Cancer Stem Cells, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2016-9_28

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