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Myc in Stem Cell Behaviour: Insights from Drosophila

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Transcriptional and Translational Regulation of Stem Cells

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 786))

Abstract

The Myc family proteins are key regulators of animal growth and development, which have critical roles in modulating stem cell behaviour. Since the identification of the oncogenic potential of c-Myc in the early 1980s the mammalian Myc family, which is comprised of c-Myc, N-Myc, and L-Myc, has been studied extensively. dMyc, the only Drosophila member of the Myc gene family, is orthologous to the mammalian c-Myc oncoprotein. Here we discuss key studies addressing the function of the Myc family in stem cell behaviour in both Drosophila Models and mammalian systems.

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Acknowledgements

Thanks to Bob Eisenman and David Stein for the dMyc antibodies and to the Vienna Drosophila Research Centre (VDRC) for the dMyc RNAi lines. This work was supported by grants from the National Health and Medical Research Council (NHMRC).

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  1. Department of Anatomy and Neuroscience, University of Melbourne, Parkville, Melbourne, 3010, VIC, Australia

    Leonie M. Quinn & Gary R. Hime

  2. Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, NY, 10461, USA

    Julie Secombe

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  1. Leonie M. Quinn
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  2. Julie Secombe
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  3. Gary R. Hime
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Correspondence to Leonie M. Quinn .

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Editors and Affiliations

  1. , Anatomy and Neuroscience, University of Melbourne, VIC Grattan Street, Parkville, 3010, Victoria, Australia

    Gary Hime

  2. , Anatomy and Developmental Biology, Monash University, Monash University, Clayton, 3800, Victoria, Australia

    Helen Abud

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© 2013 Springer Science+Business Media Dordrecht

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Quinn, L.M., Secombe, J., Hime, G.R. (2013). Myc in Stem Cell Behaviour: Insights from Drosophila . In: Hime, G., Abud, H. (eds) Transcriptional and Translational Regulation of Stem Cells. Advances in Experimental Medicine and Biology, vol 786. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6621-1_15

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