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Coronary circulation and 5-hydroxytryptamine

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Cardiovascular Pharmacology of 5-Hydroxytryptamine

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Abstract

Coronary vasospasm or Prinzmetal’s variant angina [1] is probably caused by a variety of substances that arise from aggregating platelets, from nerve varicosities or from different cells within the wall itself. It may not however, be simply a matter of identifying some pathological constrictor substance. The vascular reactivity, defined here by the “sensitivity” of the artery to the substance (conveniently taken as the EC50) and by the “range” or magnitude (Emax) of the contraction may have changed considerably in patients with angina pectoris.

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Authors
  1. James A. Angus
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  2. Archer Broughton
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  3. Thomas M. Cocks
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  4. Christine E. Wright
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Erasmus University, Rotterdam, The Netherlands

    P. R. Saxena

  2. Department of Physiology, University of Wales, College of Cardiff, Cardiff, UK

    D. I. Wallis

  3. Department of Pharmacology, Duphar B.V, Weesp, The Netherlands

    W. Wouters  & P. Bevan  & 

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© 1990 Springer Science+Business Media Dordrecht

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Angus, J.A., Broughton, A., Cocks, T.M., Wright, C.E. (1990). Coronary circulation and 5-hydroxytryptamine. In: Saxena, P.R., Wallis, D.I., Wouters, W., Bevan, P. (eds) Cardiovascular Pharmacology of 5-Hydroxytryptamine. Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine, vol 106. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0479-8_32

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  • DOI: https://doi.org/10.1007/978-94-009-0479-8_32

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6701-0

  • Online ISBN: 978-94-009-0479-8

  • eBook Packages: Springer Book Archive

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