Abstract
In the late forties and early fifties 5-hydroxytryptamine (serotonin, 5-HT) was a fashionable research area, but thereafter activity declined and the field remained dormant for almost 20 years. During the past decade there has been renewed and steadily increasing interest, largely due to the availability of many new compounds with claimed selectivity for 5-HT receptor subtypes. Whilst some of them indeed show true selectivity, the majority of these compounds have appreciable affinity either for more than one 5-HT receptor subtype, or for other neurotransmitter receptors, and this limits their usefulness. Here we provide an update on the pharmacological properties of some of the more commonly used agonists and antagonists at 5-HT receptors, in an attempt to identify those compounds, or combinations of compounds, which can be reliably used for the characterization of 5-HT receptors.
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Richardson, B.P., Hoyer, D. (1990). Selective Agonists and Antagonists at 5-Hydroxytryptamine Receptor Subtypes. In: Paoletti, R., Vanhoutte, P.M., Brunello, N., Maggi, F.M. (eds) Serotonin. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1912-9_34
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DOI: https://doi.org/10.1007/978-94-009-1912-9_34
Publisher Name: Springer, Dordrecht
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