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Role of cell attachment proteins in defining cell-matrix interactions

  • Chapter
Tumor Invasion and Metastasis

Part of the book series: Developments in Oncology ((DION,volume 7))

Abstract

Recent studies indicate that most normal cells require an extracellular matrix for survival, proliferation, differentiation, and migration [for review see 1]. The components of a given matrix contain unique constituents including one or more genetically distinct collagens (Table 1) and proteoglycans (Table 2). In addition, cell- and matrix-specific glycoproteins such as fibronectin, laminin, and chondronectin (Table 3) are present as attachment factors to bind cells into the matrix. The matrix provides the structural support for the tissue, and the ability of a cell to adhere to the matrix determines which cells will be found in a tissue and controls how and when the cells will synthesize matrix, differentiate, and migrate.

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  1. H. K. Kleinman
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  1. National Cancer Institute, Bethesda, Maryland, USA

    L. A. Liotta

  2. Frederick Cancer Research Center, Frederick, Maryland, USA

    I. R. Hart

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© 1982 Martinus Nijhoff Publishers, The Hague/Boston/London

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Kleinman, H.K. (1982). Role of cell attachment proteins in defining cell-matrix interactions. In: Liotta, L.A., Hart, I.R. (eds) Tumor Invasion and Metastasis. Developments in Oncology, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7511-8_17

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  • DOI: https://doi.org/10.1007/978-94-009-7511-8_17

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