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Factors Modifying the Fusion of Phagosomes and Lysosomes: Art, Fact, and Artefact

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Mononuclear Phagocytes

Abstract

In their heuristic studies, Fell and Mellanby (1950,1952) described the destructive effects of vitamin A acetate on limb-bone rudiments and other tissues from mouse and chick embryos in tissue culture. The dissolution of, e.g., cartilage muco-protein associated with the tissue destruction was ultimately linked to proteolytic (cathepsin) activity released from tissue lysosomes which were rendered fragile and unstable, probably owing to a drug-induced labilization of lysosomal (and other) membranes.

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Authors
  1. M. B. Goren
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  2. C. L. Swendsen
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  3. Janet Henson
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Editor information

Editors and Affiliations

  1. Department of Infectious Diseases, University Hospital, Leiden, The Netherlands

    Ralph van Furth

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Goren, M.B., Swendsen, C.L., Henson, J. (1980). Factors Modifying the Fusion of Phagosomes and Lysosomes: Art, Fact, and Artefact. In: van Furth, R. (eds) Mononuclear Phagocytes. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8793-7_39

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  • DOI: https://doi.org/10.1007/978-94-009-8793-7_39

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-8795-1

  • Online ISBN: 978-94-009-8793-7

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