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Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment pp 445–455Cite as

Tin-Based Antitumor Drugs

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Part of the book series: NATO ASI Series ((ASEN2,volume 26))

Abstract

An overview is given of the results of the in vitro screening against MCF-7, a mammary tumor, and WiDr, a colon carcinoma, of several series of organotin compounds: diorganotin pyridinedicarboxylates, bis(salicylato)tetraorgano-distannoxanes, diorganotin and triorganotin benzoates.

Many di-and triorganotin compounds exhibit very promising in vitro antitumor activities: di-n-butyltin 2, 6-difluorobenzoate and triphenyltin salicylates are characterized by ID50 values comparable to that of mitomycin C.

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References

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Authors and Affiliations

  1. Faculty of Applied Sciences, Department of General and Organic Chemistry, Free University of Brussels V.U.B., Room 8G512, Pleinlaan 2, B-1050, Brussel, Belgium

    M. Gielen

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  1. M. Gielen
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Editors and Affiliations

  1. Laboratory of Inorganic and General Chemistry, Department of Chemistry, University of Ioannina, Ioannina, Greece

    Nick D. Hadjiliadis

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© 1997 Springer Science+Business Media Dordrecht

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Gielen, M. (1997). Tin-Based Antitumor Drugs. In: Hadjiliadis, N.D. (eds) Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment. NATO ASI Series, vol 26. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5780-3_27

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  • DOI: https://doi.org/10.1007/978-94-011-5780-3_27

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6440-8

  • Online ISBN: 978-94-011-5780-3

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