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Immunological Aspects of Eclampsia and Pre-eclampsia

  • Chapter
Immunological Aspects of Reproduction and Fertility Control

Abstract

Pre-eclampsia/eclainpsia is a disorder of the second half of human pregnancy, and a principal cause of both maternal and perinatal mortality and morbidity. Its cause is unknown and its investigation is constrained by the lack of any equivalent disorder in other mammalian species. The diagnosis of pre-eclampsia varies between different investigators — it may be a syndrome with several different aetiologies rather than a single disease entity.

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References

  1. Sims, E. A. H. (1970). Pre-eclampsia and related complications of pregnancy. Am. J. Obstet. Gynecol., 107, 154

    PubMed  CAS  Google Scholar 

  2. Bonnar, J., McNichol, G. P. and Douglas, A. S. (1971). Coagulation and fibrinolytic systems in pre-eclampsia and eclampsia. Br. Med. J., 2, 12

    PubMed  CAS  Google Scholar 

  3. Department of Health and Social Security (1979). Report on Confidential Enquiries into Maternal deaths in England and Wales 1973–1975, p. 21. ( London: HMSO )

    Google Scholar 

  4. McCartney, C. P. (1964). Pathological anatomy of acute hypertension of pregnancy. Circulation, 29 ( Suppl. II ), 37

    Google Scholar 

  5. Little, W. A. (1960). Placental infarction. Obstet. Gynecol., 15, 109

    PubMed  CAS  Google Scholar 

  6. Hibbard, B. M. and Jeffcoate, T. N. A. (1966). Abruptio placentae. Obstet. Gynecol., 27, 155

    PubMed  CAS  Google Scholar 

  7. Scott, J. R. and Beer, A. A. (1976). Immunologic aspects of pre-eclampsia. Am. J. Obstet. Gynecol., 125, 418

    PubMed  CAS  Google Scholar 

  8. Jenkins, D. M. (1977). immunological aspects of the pathogenesis of pregnancy hypertension. Clin. Obstet. Gynaecol., 4, 665

    Google Scholar 

  9. Kitzmiller, J. L. (1977). Immunologic approaches to the study of pre-eclampsia. Clin. Obstet. Gynaecol., 20, 717

    CAS  Google Scholar 

  10. Willems, J. (1977). The etiology of pre-eclampsia. Obstet. Gynecol., 50, 495

    PubMed  CAS  Google Scholar 

  11. Scott, J. S., Jenkins, D. M. and Need, J. A. (1978). Immunology ofpre-eclampsia. Lancet, 1, 704

    PubMed  CAS  Google Scholar 

  12. Beer, A. E. (1978). Possible immunologic bases of pre-eclampsia/eclampsia. Semin. Perinatol., 2, 39

    PubMed  CAS  Google Scholar 

  13. Rocklin, R. E., Kitzmiller, J. L. and Kaye, M. D. (1979). Immunobiology of the maternal-fetal relationship. Ann. Rev. Med., 30, 375

    PubMed  CAS  Google Scholar 

  14. Need, J. A. (1979). Immunological phenomena in pre-eclamptic toxaemia. Clin. Obstet. Gynaecol., 6, 443

    PubMed  CAS  Google Scholar 

  15. MacGillivray, I. (1958). Some observations on the incidence of pre-eclampsia. Br. J. Obstet. Gynaecol., 65, 536

    CAS  Google Scholar 

  16. Need, J. A. (1975). Pre-eclampsia in pregnancies by different fathers: immunological studies. Br. Med. J., 1, 548

    PubMed  CAS  Google Scholar 

  17. Feeney, J. G. (1980). Pre-eclampsia and changed paternity. Proceedings of 1st Congress of the International Society for the Study of Hypertension in Pregnancy. (In press)

    Google Scholar 

  18. Marti, J. J. and Herrman, U. (1977). Immunogestosis. A new concept of `essential’ EPH gestosis, with special consideration of the primigravid patient. Am. J. Obstet. Gynecol., 128, 489

    PubMed  CAS  Google Scholar 

  19. Feeney, J. G., Tovey, L. A. D. and Scott, J. S. (1977). Influence of previous blood transfusion on incidence of pre-eclampsia. Lancet, 1, 874

    PubMed  CAS  Google Scholar 

  20. Stiller, C. R., Sinclair, N. R., Sheppard, R. R., Lockwood, B. L., Ulan, R. A., Sharpe, J. A. and Hayman, P. (1978). Beneficial effect of operation-day blood transfusions on human renal-allograft survival. Lancet, 1, 169

    PubMed  CAS  Google Scholar 

  21. Robertson, W. B., Brosens, I. and Dixon, H. G. (1967). The pathological response of the vessels of the placental bed to hypertensive pregnancy. J. Pathol. Bacteriol., 93, 581

    PubMed  CAS  Google Scholar 

  22. Zeek, P. M. and Assali, N. S. (1950). Vascular changes in decidua associated with eclamptogenic toxemia of pregnancy. Am. J. Clin. Pathol., 20, 1099

    PubMed  CAS  Google Scholar 

  23. McClure Browne, J. C. and Veall, N. (1953). The maternal placental blood flow in normotensive and hypertensive women. Br. J. Obstet. Gynaecol., 60, 141

    Google Scholar 

  24. Fox, H. (1964). The villous cytotrophoblast as an index of placental ischaemia. Br. J. Obstet. Gynaecol., 71, 885

    CAS  Google Scholar 

  25. Cibils, L. A. (1974). The placenta and newborn infant in hypertensive conditions. Am. J. Obstet. Gynecol., 118, 256

    PubMed  CAS  Google Scholar 

  26. Hume, D. M., Merrill, J. P., Miller, B. F. and Thorn, G. W. (1955). Experiences with renal homotransplantation in the human: report of nine cases. J. Clin. Invest., 34, 327

    PubMed  CAS  Google Scholar 

  27. Porter, K. A., Thomson, W. B., Owen, K., Kenyon, J. R., Mowbray, J. F. and Peart, W. S. (1963). Obliterative vascular changes in four human kidney homotransplants. Br. Med. J., 2, 639

    PubMed  CAS  Google Scholar 

  28. Sheppard, B. L. and Bonnar, J. (1976). The ultrastructure of the arterial supply of the human placenta in pregnancy complicated by fetal growth retardation. Br. J. Obstet. Gynaecol., 83, 948

    PubMed  CAS  Google Scholar 

  29. Clemetson, C. A. B. (1960). Aortic hypoplasia and its significance in the aetiology of preeclamptic toxaemia. Br. J. Obstet. Gynaecol., 67, 90

    CAS  Google Scholar 

  30. Cavanagh, D., Papineni, S., Cheng Tsai, C. and O’Connor, T. C. (1977). Experimental toxemia in the pregnant primate. Am. J. Obstet. Gynecol., 128, 75

    PubMed  CAS  Google Scholar 

  31. Kumar, D. (1962). Chronic placental ischemia in relation to toxemias of pregnancy. Am. J. Obstet. Gynecol., 84, 1323

    Google Scholar 

  32. Abitbol, M. M. (1977). Hemodynamic studies in experimental toxemia of the dog. Obstet. Gynecol., 50, 293

    PubMed  CAS  Google Scholar 

  33. Wardle, E. N. and Wright, N. A. (1973). Role of fibrin in a model of pregnancy toxaemia in the rabbit. Am. J. Obstet. Gynecol., 115, 17

    PubMed  CAS  Google Scholar 

  34. Douglas, B. H. and Langford, H. G. (1969). Post-term blood pressure elevation produced by uterine wrapping. Am. J. Obstet. Gynecol., 97, 231

    Google Scholar 

  35. Skinner, S. L., Lumbers, E. R. and Symonds, E. M. (1968). Renin concentration in human fetal and maternal tissues. Am. J. Obstet. Gynecol., 101, 529

    PubMed  CAS  Google Scholar 

  36. Ferris, T. F., Stein, J. H. and Kauffman, J. (1972). Uterine blood flow and uterine renin secretion. J. Clin. Invest., 51, 2827

    PubMed  CAS  Google Scholar 

  37. Symonds, E. M., Broughton-Pipkin, F. and Craven, D. J. (1975). Changes in the renin-angiotensin system in primigravidae with hypertensive disease of pregnancy. Br. J. Obstet. Gynaecol., 82, 643

    PubMed  CAS  Google Scholar 

  38. Weir, R. J., Fraser, R., Lever, A. F., Morton, J. J., Brown, J. J., Kraszewski, A., Mcllwaine, G. M., Robertson, J. I. S. and Tree, M. (1973). Plasma renin, renin substrate, angiotensin II and aldosterone in hypertensive disease of pregnancy. Lancet, 1, 291

    Google Scholar 

  39. Kokot, F. and Cekânski, A. (1972). Plasma renin activity in peripheral and uterine vein blood in pregnant and non-pregnant women. J. Obstet. Gynaecol. Br. Commonw., 79, 72

    PubMed  CAS  Google Scholar 

  40. Jeffcoate, T. N. A. and Scott, J. S. (1959). Some observations on the placental factor in pregnancy toxaemia. Am. J. Obstet. Gynecol., 77, 475

    PubMed  CAS  Google Scholar 

  41. Niebuhr, E. (1974). Triploidy in man. Humangenetik, 21, 103

    PubMed  CAS  Google Scholar 

  42. McFarlane, A. and Scott, J. S. (1976). Pre-eclampsia/eclampsia in twin pregnancies. J. Med. Genet., 13, 208

    PubMed  CAS  Google Scholar 

  43. Thomas, L., Douglas, G. W. and Carr, M. C. (1959). The continual migration of syncytial trophoblasts from the fetal placenta into the maternal circulation. Trans. Assoc. Am. Physicians, 72, 140

    Google Scholar 

  44. Attwood, H. D. and Park, W. W. (1961). Embolism to the lungs by trophoblast. Br. J. Obstet. Gynaecol., 68, 611

    CAS  Google Scholar 

  45. Jaameri, K. E. U., Koivuniemi, A. P. and Carpén, E. O. (1965). Occurrence of trophoblasts in the blood of toxaemic patients. Gynaecologia, 160, 315

    PubMed  CAS  Google Scholar 

  46. Faulk, W. P. and Temple, A. (1976). Distribution of 32-microglobulin and HLA in chorionic villi of human placentae. Nature (London), 262, 799

    CAS  Google Scholar 

  47. Goodfellow, P. N., Barnstable, C. J., Bodmer, W. F., Snary, D. and Crumpton, M. J. (1976). Expression of HLA system antigens on placenta. Transplantation, 22, 595

    PubMed  CAS  Google Scholar 

  48. Stirrat, G. M., Mason, D. and Redman, C. W. G. (1979). Absence of HLA on human trophoblasts demonstrated by immunofluorescence with a monoclonal anti-HLA antibody. ( Unpublished observations )

    Google Scholar 

  49. Barnstable, C. J. and Bodmer, W. F. (1978). Immunology and the fetus. Lancet, 1, 326

    Google Scholar 

  50. Hulka, J. F., Hsu, K. C. and Beiser, S. M. (1961). Antibodies to trophoblasts during the post-partum period. Nature (London), 191, 510

    CAS  Google Scholar 

  51. Kaku, M. (1953). Placental polysaccharide and the aetiology of the toxaemia of pregnancy. J. Obstet. Gynaecol. Br. Commomv., 60, 148

    CAS  Google Scholar 

  52. Gaugas, J. M. and Curzen, P. (1974). Complement fixing antibody against solubilised placental microsomal fraction in pre-eclampsia sera. Br. J. Exp. Patliot.,55 570

    Google Scholar 

  53. Hulka, J. F. and Brinton, V. (1963). Antibody to trophoblast during early post-partum period in toxemic pregnancies. Am. J. Obstet. Gynecol.,86 130

    Google Scholar 

  54. Vardi, I. and Halbrecht, I. (1974). Toxemia of pregnancy: 1. Antigens associated with toxemia of pregnancy in placental connective tissue. Am. J. Obstet. Gynecol., 118, 552

    PubMed  CAS  Google Scholar 

  55. Youtananukorn, V., Matangkasombut, P. and Osathanondh, V. (1974). Onset of human maternal cell-mediated immune reaction to placental antigens during the first pregnancy. Clin. Exp. Immunol., 16, 593

    PubMed  CAS  Google Scholar 

  56. Stimson, W. H., Strachan, A. F. and Shepherd, A. (1979). Studies on the maternal immune response to placental antigens: absence of a blocking factor from the blood of abortion-prone women. Br. J. Obstet. Gynaecol., 86, 41

    PubMed  CAS  Google Scholar 

  57. Taylor, P. V. and Hancock, K. W. (1975). Antigenicity of trophoblast and possible antigen-masking effects during pregnancy. J. Immunol., 28, 973

    CAS  Google Scholar 

  58. Rocklin, R. E., Kitzmiller, J. L., Carpenter, C. B., Garovoy, M. R. and David, J. R. (1976). Maternal fetal relation. Absence of an immunologic blocking factor from the serum of women with chronic abortions. N. Engl. J. Med., 295, 1209

    PubMed  CAS  Google Scholar 

  59. McIntyre, J. A. and Faulk, W. P. (1979). Maternal blocking factors in human pregnancy are found in plasma not serum. Lancet, 2, 821

    PubMed  CAS  Google Scholar 

  60. Baxter, J. H. and Goodman, H. C. (1956). Nephrotoxic serum nephritis in rats. J. Exp. Med., 104, 467

    PubMed  CAS  Google Scholar 

  61. Steblay, R. W. (1962). Localisation in human kidney of antibodies formed in sheep against human placenta. J. Immunol., 88, 434

    PubMed  CAS  Google Scholar 

  62. Curzen, P. (1968). The antigenicity of human placenta. Br. J. Obstet. Gynaecol., 75, 1128

    CAS  Google Scholar 

  63. Boss, J. H. (1965). Antigenic relationships between placenta and kidney in the human. Am. J. Obstet. Gynecol., 93, 574

    PubMed  CAS  Google Scholar 

  64. Seegal, B. C. and Loeb, E. N. (1946). The production of chronic glomerulonephritis in rats by the injection of rabbit anti-rat-placenta serum. J. Exp. Med., 84, 211

    Google Scholar 

  65. McCaughy, W. T. E. (1955). The nephrotoxic action of anti-placenta serum in rats. Br. J. Obstet. Gynaecol., 62, 863

    Google Scholar 

  66. Okuda, T. and Grollman, A. (1966). Renal lesions in rats following injection of placental extracts. Arch. Pathol., 82, 246

    PubMed  CAS  Google Scholar 

  67. Irino, T., Okuda, T. and Grollman, A. (1967). Changes induced in the glomeruli of the kidney of rats by placental extracts as observed with the electron microscope. Am. J. Pathol., 50, 421

    PubMed  CAS  Google Scholar 

  68. Gang, N. F., Schwarz, E. S., Majerovics, A., De Champlain, M.-L. and Trachtenberg, E. (1974). Studies on the placenta. II. Nephrotoxicity of antibodies produced against a chorionic glycoprotein. Am. J. Obstet. Gynecol., 120, 73

    PubMed  CAS  Google Scholar 

  69. Singal, D. P., Mickey, M. R. and Terasaki, P. I. (1969). Serotyping for homotransplantation. XXIII. Analysis of kidney transplants from parental versus sibling donors. Transplantation, 7, 246

    PubMed  CAS  Google Scholar 

  70. Robertson, W. B., Brosens, I. and Dixon, G. (1976). Maternal uterine vascular lesions in the hypertensive complications of pregnancy. Perspect. Nephrol. Hyperten., 5, 115

    CAS  Google Scholar 

  71. Stevenson, A. C., Davison, B. C. C., Say, B., Ustuoplus, L. D., Einen, M. A. and Toppozada, H. K. (1971). Contribution of fetal/maternal incompatibility to aetiology of pre-eclamptic toxaemia. Lancet, 2, 1286

    PubMed  CAS  Google Scholar 

  72. Stevenson, A. C., Say, B., Ustaoglu, S. and Durmus, Z. (1976). Aspects of pre-eclamptic toxaemia of pregnancy, consanguinity and twinning in Ankara. J. Med. Genet., 13, 1

    PubMed  CAS  Google Scholar 

  73. Toivanen, P. and Hirvonen, T. (1970). Sex ratio of newborn; preponderance of males in toxaemia of pregnancy. Science, 170, 187

    PubMed  CAS  Google Scholar 

  74. Redman, C. W. G., Bodmer, J. G., Bodmer, W. F., Beilin, L. J. and Bonnar, J. (1978). HLA antigens in severe pre-eclampsia. Lancet, 2, 397

    PubMed  CAS  Google Scholar 

  75. Jenkins, D. M., Need, J. A., Scott, J. S., Morris, H. and Pepper, M. (1978). Human leukocyte antigens and mixed lymphocyte reaction in severe pre-eclampsia. Br. Med. J., 1, 542

    PubMed  CAS  Google Scholar 

  76. Terasaki, P. I., Mickey, M. R. and Yamazaki, J. N. (1970). Maternal-fetal incompatibility. I. Incidence of HLA antibodies and possible association with congenital anomalies. Transplantation, 9, 538

    PubMed  CAS  Google Scholar 

  77. Jenkins, D. M., Need, J. and Rajah, S. M. (1977). Deficiency of specific HLA antibodies in severe pregnancy pre-eclampsiajeclampsia. Clin. Exp. Immunol., 27, 485

    PubMed  CAS  Google Scholar 

  78. Fingleton, A. M. (1971). Leucocytotoxic antibodies and pre-eclampsia of pregnancy. Transplantation, 12, 319

    PubMed  CAS  Google Scholar 

  79. Tiilikainen, A. (1971). Fetomaternal histoincompatibility in toxaemia of pregnancy. In Grubb, R. and Samuelsson, G. (eds.) Human Anti-Human Gammaglobulins, pp. 223–277. ( Oxford: Pergamon Press )

    Google Scholar 

  80. Caretti, N., Chiaramonte, P., Pasini, C., Zenetti, M. and Fagiolo, U. (1974). Association of anti-HLA antibodies with toxaemia of pregnancy. In Centaro, A., Caretti, N. and Addison, G. M. (eds.) Immunology in Obstetrics and Gynecology, pp. 221–225. (Excerpta Medica)

    Google Scholar 

  81. Nymand, G. (1975). Complement-fixing and lymphocytotoxic antibodies in serum of pregnant women at delivery. Vox. Sang., 28, 101

    PubMed  CAS  Google Scholar 

  82. Harris, R. E. and Lordon, R. E. (1976). The association of maternal lymphocytotoxic antibodies with obstetric complications. Obstet. Gynecol., 48, 302

    PubMed  CAS  Google Scholar 

  83. Davies, D. A. L. and Staines, N. A. (1976). A cardinal role for I-region antigens (Ia) in immunological enhancement, and the clinical implications. Transplant. Rev., 30, 18

    PubMed  CAS  Google Scholar 

  84. Festenstein, H. and Démant, P. (1978). HLA and H-2. Basic immunogenetics, Biology and Clinical Relevance, pp. 16–89. ( London: Edward Arnold )

    Google Scholar 

  85. McDevitt, H. O. and Bodmer, W. F. (1972). Histocompatibility antigens, immune responsiveness and susceptibility to disease. Am. J. Med., 52, 1

    PubMed  CAS  Google Scholar 

  86. Scott, J. R., Beer, A. E. and Stastny, P. (1976). Immunogenetic factors in pre-eclampsia and eclampsia. J. Am. Med. Assoc., 235, 402

    CAS  Google Scholar 

  87. Kalmus, H. (1946). Genetical antigenic incompatibility as a possible cause of the toxaemias occurring late in pregnancy. Ann. Engen., 13, 146

    CAS  Google Scholar 

  88. Penrose, L. S. (1946). On the familial appearances of maternal and fetal incompatibility. Ann. Eugen., 13, 141

    PubMed  CAS  Google Scholar 

  89. Platt, R. (1947). The problem of Bright’s disease. Practitioner, 159, 159

    PubMed  CAS  Google Scholar 

  90. Adams, E. M. and Finlayson, A. (1961). Familial aspects of pre-eclampsia and hypertension in pregnancy. Lancet, 2, 1375

    PubMed  CAS  Google Scholar 

  91. Chesley, L. C., Annitto, J. E. and Cosgrove, R. A. (1968). The familial factor in toxaemia of pregnancy. Obstet. Gynaecol., 32, 303

    CAS  Google Scholar 

  92. Humphries, J. O’Neal (1960). Occurrence of hypertensive toxemia of pregnancy in mother-daughter pairs. Bull. Johns Hopkins Hasp., 107, 271

    Google Scholar 

  93. Cooper, D. W. and Liston, W. A. (1979). Genetic control of severe pre-eclampsia. J. Med. Genet., 16, 409

    PubMed  CAS  Google Scholar 

  94. Brocklehurst, J. C. and Ross, R. (1960). Familial eclampsia. J. Obstet. Gynaecol. Br. Emp., 67, 971

    Google Scholar 

  95. Pike, L. A. and Dickins, A. M. (1954). ABO blood groups and toxaemia of pregnancy. Br. Med. J., 2, 321

    PubMed  CAS  Google Scholar 

  96. May, D. (1973). Maternal blood group A and pre-eclampsia. Br. Med.J., 4, 738

    PubMed  CAS  Google Scholar 

  97. Harlap, S. and Davies, A. M. (1974). Maternal blood group A and pre-eclampsia. Br. Med. J., 3, 171

    PubMed  CAS  Google Scholar 

  98. Pearson, M. G. and Pinker, G. D. (1956). ABO blood groups and toxaemia of pregnancy. Br. Med. J., 1, 777

    PubMed  CAS  Google Scholar 

  99. Andrews, G. S. (1959). Blood groups and toxaemia of pregnancy. Br. Med. J., 2, 806

    PubMed  CAS  Google Scholar 

  100. Salzmann, K. D. (1955). Do transplacental hormones cause eclampsia? Lancet, 2, 953

    Google Scholar 

  101. Juberg, R. R., Gaar, D. G., Humphries, J. R., Cenac, P. L. and Zambie, M. F. (1976). Sex ratio in the progeny of mothers with toxemia of pregnancy. J. Reprod. Med., 16, 299

    PubMed  CAS  Google Scholar 

  102. Gusdon, J. P., Heise, E. R. and Herbst, G. A. (1977). Studies of lymphocyte populations in pre-eclampsia/eclampsia. Am. J. Obstet. Gynecol., 129, 255

    PubMed  Google Scholar 

  103. Hersh, E. M., Butler, W. T., Rossen, R. D. and Morgen, R. O. (1970). Lymphocyte activation; a rapid test to predict allograft rejection. Nature (London), 226, 757

    CAS  Google Scholar 

  104. Gaugas, J. M., Jones, E. and Curzen, P. (1975). Spontaneous lymphocyte transformation in pregnancies complicated by pre-eclampsia. Am. J. Obstet. Gynecol., 121, 542

    PubMed  CAS  Google Scholar 

  105. Petrucco, O. M., Seamark, R. F., Holmes, K., Forbes, I. J. and Symonds, R. G. (1976). Changes in lymphocyte function during pregnancy. Br. J. Obstet: Gynaecol., 83, 245

    CAS  Google Scholar 

  106. Purtilo, D. T., Hallgren, H. M. and Yunis, E. J. (1972). Depressed maternal lymphocyte response to phytohaemagglutinin in human pregnancy. Lancet, 2, 769

    Google Scholar 

  107. Need, J. A., Jenkins, D. M. and Scott, J. S. (1976). The response of lymphocytes to phytohaemagglutinin in women with pre-eclampsia. Br. J. Obstet. Gynecol., 83, 438

    CAS  Google Scholar 

  108. Griffin, J. F. T. and Wilson, E. M. (1979). Lymphocyte response to phytohaemagglutinin in pre-eclampsia. Int. J. Lab. Clin. Immunol. (In press)

    Google Scholar 

  109. Birkeland, S. A. and Kristofferson, K. (1979). Pre-eclampsia - a state of mother-fetus immune imbalance. Lancet, 2, 720

    PubMed  CAS  Google Scholar 

  110. Halbrecht, I. G. and Komlos, L. (1974). Mixed wife-husband leukocyte cultures in disturbed and pathological pregnancies. Isr. J. Med. Sci., 10, 1100

    PubMed  CAS  Google Scholar 

  111. Curzen, P., Jones, E. and Gaugas, J. M. (1977). Maternal-fetal mixed lymphocyte reactivity in pre-eclampsia. Br. J. Exp. Pathol., 58, 500

    PubMed  CAS  Google Scholar 

  112. Gille, J., Williams, J. H. and Hoffman, C. P. (1977). The feto-maternal lymphocyte interaction in pre-eclampsia and in uncomplicated pregnancy. Eur. J. Obstet. Gynaecol. Reprod. Biol., 7, 227

    Google Scholar 

  113. Thiry, L., Sprecher-Goldberger, S., Bossens, M. and Neukay, F. (1978). Immune response to primate oncornaviruses in pre-eclampsia. Lancet, 1, 1268

    PubMed  CAS  Google Scholar 

  114. Ablin, R. M., Bruns, G. R. and Guinan, P. (1974). The effect of estrogen on the incorporation of 3H-thymidine by PHA-stimulated human peripheral blood. J. Immunol., 113, 705

    PubMed  CAS  Google Scholar 

  115. Simmons, R. L., Price, A. L. and Ozerkis, A. J. (1968). The immunologic problems of pregnancy. V. The effect of estrogen and progesterone on allograft survival. Am. J. Obstet. Gynecol., 100, 908

    PubMed  CAS  Google Scholar 

  116. Contractor, S. F. and Davies, H. (1973). Effect of human chorionic somatomammotrophin and human chorionic gonadotrophin on phytohaemagglutinin-induced lymphocyte transformation. Nature (New Biol.), 243, 284

    CAS  Google Scholar 

  117. Masson, G. M. (1973). Plasma oestriol in pre-eclampsia. J. Obstet. Gynaecol. Br. Commonw., 80, 206

    PubMed  CAS  Google Scholar 

  118. Letchworth, A. T. and Chard, T.. (1972). Human placental lactogen levels in pre-eclampsia. J. Obstet. Gynaecol. Br. Commonw., 79, 680

    PubMed  CAS  Google Scholar 

  119. Eton, B. and Short, R. V. (1960). Blood progesterone levels in abnormal pregnancies. J. Obstet. Gynaecol. Br. Commonw., 67, 785.

    Google Scholar 

  120. Home, C. H. W., Briggs, J. D., Howie, P. W. and Kennedy, A. C. (1972). Serum amacroglobulins in renal disease and pre-eclampsia. J. Clin. Pathol., 25, 590

    Google Scholar 

  121. Stimson, W. H. (1975). Immunosuppressive effect of pregnancy-associated aZ macro-globulin. Lancet, 2, 989

    PubMed  CAS  Google Scholar 

  122. Jenkins, D. M., Good, W. and Good, S. (1973). Serum seromucoid and the materno-paternal mixed lymphocyte reaction following previous severe pre-eclampsia. Br. J. Obstet. Gynaecol., 80, 19

    CAS  Google Scholar 

  123. Revillard, J. P., Brochier, J., Robert, M., Bonneau, M. and Traeger, J. (1975) Immunologic properties of placental eluates. Transplant. Proc., VIII, 275

    Google Scholar 

  124. Faulk, W. P., Temple, A., Lovins, R. E. and Smith, N. (1978). Antigens of human trophoblasts: a working hypothesis for their role in normal and abnormal pregnancies. Proc. Natl. Acad. Sci., 75, 1947

    PubMed  CAS  Google Scholar 

  125. Horne, C. H. W., Howie, P. W. and Goudie, R. B. (1970). Serum alpha2-macroglobulin, transferrin, albumin and IgG levels in pre-eclampsia. J. Clin. Pathol., 23, 514

    PubMed  CAS  Google Scholar 

  126. Benster, B. and Wood, E. J. (1970). Immunoglobulin levels in normal pregnancy and pregnancy complicated by hypertension. Br. J. Obstet. Gynaecol., 77, 518

    CAS  Google Scholar 

  127. Kelly, A. M. and McEwan, H. P. (1973). Proteinuria in pre-eclamptic toxaemia of pregnancy. J. Obstet. Gynaecol. Br. Commonw., 80, 520

    PubMed  CAS  Google Scholar 

  128. Studd, J. W. W. (1971). Immunoglobulins in normal pregnancy, pre-eclampsia and pregnancy complicated by the nephrotic syndrome. J. Obstet. Gynaecol. Br. Commonw., 78, 786

    PubMed  CAS  Google Scholar 

  129. Masson, P. L., Delire, M. and Cambiaso, C. L. (1977). Circulating immune complexes in normal human pregnancy. Nature (London), 266, 542

    CAS  Google Scholar 

  130. McLaughlin, P. J., Stirrat, G. M., Redman, C. W. G. and Levinsky, R. J. (1979). Immune complexes in normal and pre-eclamptic pregnancy. Lancet, 1, 934

    PubMed  CAS  Google Scholar 

  131. Gleicher, N., Theofilopoulous, A. N. and Beers, P. (1978). Immune complexes in pregnancy. Lancet, 1, 1108

    Google Scholar 

  132. Knox, G. E., Stagno, S., Volanakis, J. E. and Huddleston, J. F. (1978). A search for antigen-antibody complexes in pre-eclampsia; further evidence against immunologic pathogenesis. Am. J. Obstet. Gynecol., 132, 87

    PubMed  CAS  Google Scholar 

  133. D’Amelio, R., Bilotta, P., Pachi, A. and Aiuti, F. (1979). Circulating immune complexes in normal pregnant women and in some conditions complicating pregnancy. Clin. Exp. Immunol., 37, 33

    PubMed  Google Scholar 

  134. Stirrat, G. M., Redman, C. W. G. and Levinsky, R. J. (1978). Circulating immune complexes in pre-eclampsia. Br. Med. J., 1, 1450

    PubMed  CAS  Google Scholar 

  135. Petrucco, O. M., Thomson, N. M., Lawrence, J. R. and Weldon, M. W. (1974). Immunofluorescent studies in renal biopsies in pre-eclampsia. Br. Med. J., 1, 473

    PubMed  CAS  Google Scholar 

  136. Tribe, C. R., Smart, G. E. and Mackenzie, J. C. (1974). Pre-eclampsia and the kidney. Br. Med. J., 2, 335

    PubMed  CAS  Google Scholar 

  137. Seymour, A. E., Petrucco, O. M., Clarkson, A. R., Haynes, W. D. G., Lawrence, J. R., Jackson, B., Thompson, A. J. and Thomson, N. M. (1976). Morphological and immunological evidence of coagulopathy in renal complications of pregnancy. Perspect. Nephrol. Hyperten., 5, 139

    CAS  Google Scholar 

  138. Spargo, B. H., Lichtig, C., Luger, A. M., Katz, A. I. and Lindheimer, M. D. (1976). The renal lesion in pre-eclampsia. Perspect. Nephrol. Hyperten., 5, 129

    CAS  Google Scholar 

  139. Kincaid-Smith, P. and Fairley, K. F. (1976). The differential diagnosis between preeclamptic toxemia and glomerulonephritis in patients with proteinuria during pregnancy. Perspect. Nephrol. Hyperten., 5, 157

    CAS  Google Scholar 

  140. Redman, C. W. G., Denson, K. W. E., Beilin, L. J., Bolton, F. J. and Stirrat, G. M. (1977). Factor-VIII consumption in pre-eclampsia. Lancet, 2, 1249

    PubMed  CAS  Google Scholar 

  141. Bokisch, V. A., Müller-Eberhard, H. J. and Cochrane, C. G. (1969). Isolation of a fragment (C3a) of the third component of human complement containing anaphylatoxin and chemotactic activity and the description of an anaphylatoxin inactivator of human serum. J. Exp. Med., 129, 1109

    PubMed  CAS  Google Scholar 

  142. Zimmerman, J. S. (1976). The coagulation mechanism and the inflammatory response. In Miescher, P. A. and Müller-Eberhard, H. J. (eds.) Textbook of Immunopathology, pp. 95–116. (New York: Grune & Stratton)

    Google Scholar 

  143. Thomson, N. C., Stevenson, R. D., Behan, W., Sloan, D. and Home, C. (1976). Immunological studies in pre-eclamptic toxaemia. Br. Med. J., 1, 1307

    PubMed  CAS  Google Scholar 

  144. Prall, R. H. and Kantor, F. S. (1966). Serum complement in eclamptogenic toxemia. Am. J. Obstet. Gynecol., 95, 530

    PubMed  CAS  Google Scholar 

  145. Kitzmiller, J. L., Stoneburner, L., Yelenosky, P. F. and Lucas, W. E. (1973). Serum complement in normal pregnancy and pre-eclampsia. Am. J. Obstet. Gynecol., 117, 312

    PubMed  CAS  Google Scholar 

  146. Fadel, H. E., Soliman, M. D. E. and El-Mehairy, M. M. (1974). Serum complement activity in pre-eclamptic pregnancies. Int. J. Gynecol. Obstet., 12, 6

    Google Scholar 

  147. Tedder, R. S., Nelson, M. and Eisen, V. (1975). Effects on serum complement of normal and pre-eclamptic pregnancy and of oral contraceptives. Br. J. Exp. Pathol., 56, 389

    PubMed  CAS  Google Scholar 

  148. Millar, K. G. and Mills, P. (1972). C13 and IgG levels in mothers and babies at delivery. Obstet. Gynecol., 39, 527

    PubMed  CAS  Google Scholar 

  149. Yang, S.-L., Kleinmann, A. and Wei, P.-Y. (1973). Immunologic aspects of term pregnancy toxemia. Am. J. Obstet. Gynecol., 122, 727

    Google Scholar 

  150. Mak, L. W. (1978). The complement profile in relation to the `reactor’ state: a study in the immediate postpartum period. Clin. Exp. Immunol., 31, 419

    PubMed  CAS  Google Scholar 

  151. Naish, P. F., Aber, G. and Boyd, W. N. (1975). C3 deposition in renal arterioles in the loin pain and haematuria syndrome. Br. Med. J., 3, 746

    PubMed  CAS  Google Scholar 

  152. Arias, F. and Mantilla-Jimenez, R. (1976). Hepatic fibrinogen deposits in pre-eclampsia. N. Engl. J. Med., 295, 578

    PubMed  CAS  Google Scholar 

  153. Kitzmiller, J. L. and Benirschke, K. (1973). Immunofluorescent study of placental bed vessels in pre-eclampsia of pregnancy. Am. J. Obstet. Gynecol., 115, 248

    PubMed  CAS  Google Scholar 

  154. Weir, P. (1979). MD Thesis. Belfast

    Google Scholar 

  155. Clarke, H. G. M., Freeman, T. and Pryse-Phillips, W. (1971). Serum proteins in normal pregnancy and mild pre-eclampsia. J. Obstet. Gynaecol. Br. Commonw., 78, 105

    PubMed  CAS  Google Scholar 

  156. Good, W. (1975). Maternal serum sialomucins during pregnancy and post-partum in patients with pre-eclampsia. Br. J. Obstet. Gynaecol., 82, 907

    PubMed  CAS  Google Scholar 

  157. Good, W., Jenkins, D. M., Collins, M. C. and Cumberbatch, K. N. (1973). Serum seromucoid levels in women with previous severe pre-eclampsia or eclampsia. Br. J. Obstet. Gynaecol., 80, 22

    CAS  Google Scholar 

  158. Fattah, M. M., Ibrahim, F. K., Ramadan, M. A. and Sammour, M. B. (1976). Ceruloplasmin and copper levels in maternal and cord blood and in the placenta in normal pregnancy and in pre-eclampsia. Acta Obstet. Gynecol. Scand., 55, 383

    PubMed  CAS  Google Scholar 

  159. Redman, C. W. G., Adinolfi, M. and Stirrat, G. M. (1979). Acute phase reactants in pre-eclampsia. ( Unpublished observations )

    Google Scholar 

  160. Scandrett, F. J. (1963). Studies of the mucoprotein content of serum and placental tissue in toxaemia of pregnancy. Br. J. Obstet. Gynaecol., 70, 78

    CAS  Google Scholar 

  161. Koj, A. (1974). Acute phase reactants. Their synthesis, turnover and biological significance. In Allison, A. C. (ed.) Structure and Function of Plasma Proteins, pp. 73–125. ( London: Plenum Press )

    Google Scholar 

  162. Stark, J. M., Johansen, K. A., Rees, J. A. and Williams, J. H. (1977). Acute-phase sera in pre-eclampsia and latent hypertension of pregnancy. Lancet, 2, 299

    PubMed  CAS  Google Scholar 

  163. Galton, M., Merritt, K. and Better, F. K. (1971). Coagulation studies on the peripheral circulation of patients with toxemia of pregnancy; a study for the evaluation of disseminated intravascular coagulation in toxemia. J. Reprod. Med., 6, 78

    PubMed  CAS  Google Scholar 

  164. Dobryszycka, W., Zeineh, R., Ebroon, E. and Kukral, J. C. (1969). Metabolism of plasma proteins in injury state. Clin. Sci., 36, 231

    PubMed  CAS  Google Scholar 

  165. Poston, R. N. and Davies, D. F. (1974). Immunity and inflammation in the pathogenesis of atherosclerosis. Atherosclerosis, 19, 353

    PubMed  CAS  Google Scholar 

  166. Mathews, J. D., Whittingham, S. and Mackay, I. R. (1974). Autoimmune mechanisms in human vascular disease. Lancet, 2, 1423

    PubMed  CAS  Google Scholar 

  167. Okuda, T. and Grollman, A. (1967). Passive transfer of autoimmune induced hypertension in the rat by lymph node cells. Tex. Rep. Biol. Med., 25, 257

    PubMed  CAS  Google Scholar 

  168. Svendsen, U. G. (1976). Evidence for an initial, thymus independent and a chronic thymus dependent phase of doca and salt hypertension in mice. Acta Pathol. Microbiol. Scand., Sect. A, 84, 523

    CAS  Google Scholar 

  169. Svendsen, U. G. (1977). The importance of thymus in the pathogenesis of the chronic phase of hypertension in mice following partial infarction of the kidney. Acta Pathol. Microbiol. Scand., Sect. A, 85, 539

    CAS  Google Scholar 

  170. Butler, N. R. and Bonham, D. G. (1963). Toxaemia in pregnancy. In Perinatal Mortality, p. 87. (Edinburgh: E. & S. Livingstone)

    Google Scholar 

  171. Chesley, L. C., Annitto, J. E. and Cosgrove, R. A. (1976). The remote prognosis of eclamptic women. Sixth periodic report. Am. J. Obstet. Gynecol., 124, 446

    PubMed  CAS  Google Scholar 

  172. Adams, E. M. and MacGillivray, I. (1961). Long-term effect of pre-eclampsia on blood pressure. Lancet, 2, 1373

    PubMed  CAS  Google Scholar 

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  1. C. W. G. Redman
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  1. The Wellcome Laboratories of Comparative Physiology, The Zoological Society of London, NW1 4RY, London, UK

    J. P. Hearn (Director) (Director)

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Redman, C.W.G. (1980). Immunological Aspects of Eclampsia and Pre-eclampsia. In: Hearn, J.P. (eds) Immunological Aspects of Reproduction and Fertility Control. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-8039-9_4

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  • DOI: https://doi.org/10.1007/978-94-011-8039-9_4

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