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Use of Non-Crystallographic Symmetry for Ab Initio Phasing of Virus Structures

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Direct Methods for Solving Macromolecular Structures

Part of the book series: NATO ASI Series ((ASIC,volume 507))

Abstract

Several virus structures have now been determined through ab initio phasing at very low (~20A) resolution followed by extension to high resolution using their non-crystallographic symmetry (NCS). The methods are described, and post-mortem investigations of phase determination are analyzed, particularly for relevance to the more challenging general case of ab initio determination of protein structure.

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Acknowledgments & References

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Author information

Authors and Affiliations

  1. Department of Chemistry & Institute of Molecular Biophysics, Florida State University, Tallahassee, FL, 32306-3015, USA

    Michael S. Chapman & Eric Blanc

  2. Department of Molecular Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd., MB-13, La Jolla, CA, 92037, USA

    John E. Johnson

  3. Department of Biological Sciences, University of Warwick, Coventry, CV4 7AL, UK

    Robert Mckenna

  4. WP44-B122, Merck & Co. Inc., West Point, PA, 19486, USA

    Sanjeev Munshi

  5. Department of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA

    Michael G. Rossmann

  6. Center for Macromolecular Crystallography, 260 BHS THT 79, University of Alabama, UAB Station, Birmingham, AL, 35294, USA

    Jun Tsao

Authors
  1. Michael S. Chapman
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  2. Eric Blanc
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  3. John E. Johnson
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  4. Robert Mckenna
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  5. Sanjeev Munshi
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  6. Michael G. Rossmann
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  7. Jun Tsao
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Editor information

Editors and Affiliations

  1. Departments of Chemistry and Computing and Information Science, Queen’s University, Kingston, Ontario, Canada

    Suzanne Fortier

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© 1998 Springer Science+Business Media New York

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Chapman, M.S. et al. (1998). Use of Non-Crystallographic Symmetry for Ab Initio Phasing of Virus Structures. In: Fortier, S. (eds) Direct Methods for Solving Macromolecular Structures. NATO ASI Series, vol 507. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9093-8_38

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  • DOI: https://doi.org/10.1007/978-94-015-9093-8_38

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-4994-0

  • Online ISBN: 978-94-015-9093-8

  • eBook Packages: Springer Book Archive

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