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Translational Research in Pain and Itch pp 117–129Cite as

Advances in the Treatment of Neuropathic Pain

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 904))

Abstract

Neuropathic pain is pain that arises as a direct consequence of a lesion or diseases affecting the somatosensory system. Treatments for neuropathic pain include pharmacological, nonpharmacological, and interventional therapies. Currently recommended first-line pharmacological treatments include antidepressants and anticonvulsants (gabapentin and pregabalin). However, in some cases, pharmacological therapy alone fails to give adequate control of the chronic pain. New techniques have been invented and have been proved effective on neuropathic pain, such as behavioral, cognitive, integrative, and physical therapies. In this review, we focused on the advances in the treatment of central neuropathic pain, diabetic peripheral neuropathy, postherpetic neuralgia, and cancer pain.

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References

  • Attal N, Bouhassira D. Pharmacotherapy of neuropathic pain: which drugs, which treatment algorithms? Pain. 2015;156 Suppl 1:S104–14.

    Article  PubMed  Google Scholar 

  • Bhatnagar S, Gupta M. Evidence-based clinical practice guidelines for interventional pain management in cancer pain. Indian J Palliat Care. 2015;21:137–47.

    Article  PubMed  PubMed Central  Google Scholar 

  • Brasch-Andersen C, Moller MU, Christiansen L, et al. A candidate gene study of serotonergic pathway genes and pain relief during treatment with escitalopram in patients with neuropathic pain shows significant association to serotonin receptor 2C (HTR2C). Eur J Clin Pharmacol. 2011;l67:1131–7.

    Article  Google Scholar 

  • Casale R, Mattia C. Building a diagnostic algorithm on localized neuropathic pain (LNP) and targeted topical treatment: focus on 5% lidocaine-medicated plaster. Ther Clin Risk Manag. 2014;10:259–68.

    Article  PubMed  PubMed Central  Google Scholar 

  • Chang KL, Fillingim R, Hurley RW, Schmidt S. Chronic pain management: nonpharmacological therapies for chronic pain. FP Essent. 2015;432:21–6.

    PubMed  Google Scholar 

  • Chua NH, Vissers KC, Sluijter ME. Pulsed radiofrequency treatment in interventional pain management: mechanisms and potential indications-a review. Acta Neurochir (Wien). 2011;153:763–71.

    Article  Google Scholar 

  • Cury RG, Galhardoni R, Fonoff ET, et al. Effects of deep brain stimulation on pain and other nonmotor symptoms in Parkinson disease. Neurology. 2014;83:1403–9.

    Article  PubMed  Google Scholar 

  • Deer TR. Spinal cord and peripheral nerve stimulation should be used earlier in the treatment algorithm for neuropathic pain. Pain Manag. 2011;1:7–10.

    Article  PubMed  Google Scholar 

  • DeFrates S, Cook AM. Pharmacologic treatment of neuropathic pain following spinal cord injury. Orthopedics. 2011;34:203.

    Article  PubMed  Google Scholar 

  • Engle MP, Vinh BP, Harun N, Koyyalagunta D. Infectious complications related to intrathecal drug delivery system and spinal cord stimulator system implantations at a comprehensive cancer pain center. Pain Physician. 2013;16:251–7.

    PubMed  Google Scholar 

  • Gilron I, Baron R, Jensen T. Neuropathic pain: principles of diagnosis and treatment. Mayo Clin Proc. 2015;90:532–45.

    Article  CAS  PubMed  Google Scholar 

  • Guirguis MN, Abd-Elsayed AA, Girgis GL, Soliman M. Ultrasound-guided transversus abdominis plane catheter for chronic abdominal pain. Pain Pract. 2013;13:235–8.

    Article  PubMed  Google Scholar 

  • Hehn CA, Baron R, Woolf CJ. Deconstructing the neuropathic pain phenotype to reveal neural mechanisms. Neuron. 2012;73:638–52.

    Article  Google Scholar 

  • Helfert SM, Reimer M, Hoper J, Baron R. Individualized pharmacological treatment of neuropathic pain. Clin Pharmacol Ther. 2015;97:135–42.

    Article  CAS  PubMed  Google Scholar 

  • Hesami O, Gharagozli K, Beladimoghadam N, Assarzadegan F, et al. The efficacy of gabapentin in patients with central post-stroke pain. Iran J Pharm Res. 2015;14:95–101.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Im SH, Ha SW, Kim DR, Son BC. Long-term results of motor cortex stimulation in the treatment of chronic, intractable neuropathic pain. Stereotact Funct Neurosurg. 2015;93:212–8.

    Article  PubMed  Google Scholar 

  • Johnson S, Ayling H, Sharma M, Goebel A. External noninvasive peripheral nerve stimulation treatment of neuropathic pain: a prospective audit. Neuromodulation. 2015;18:384–91.

    Article  PubMed  Google Scholar 

  • Jongen JL, Hans G, Benzon HT, Huygen F, Hartrick CT. Neuropathic pain and pharmacological treatment. Pain Pract. 2014;14:283–95.

    Article  PubMed  Google Scholar 

  • Juhn MS, Parsons B, Varvara R, Sadosky A. Pregabalin for painful diabetic peripheral neuropathy: strategies for dosing, monotherapy vs. combination therapy, treatment-refractory patients, and adverse events. Curr Med Res Opin. 2015;31:1017–26.

    Article  CAS  PubMed  Google Scholar 

  • Kim JS. Pharmacological management of central post-stroke pain: a practical guide. CNS Drugs. 2014;28:787–97.

    Article  CAS  PubMed  Google Scholar 

  • Kizilbash A, Ngo-Minh CT. Review of extended-release formulations of Tramadol for the management of chronic non-cancer pain: focus on marketed formulations. J Pain Res. 2014;7:149–61.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lee S, Zhao X, Hatch M, Chun S, Chang E. Central neuropathic pain in spinal cord injury. Crit Rev Phys Rehabil Med. 2013;25:159–72.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lee JW, Lee WB, Kim W, Min BI, et al. Traditional herbal medicine for cancer pain: a systematic review and meta-analysis. Complement Ther Med. 2015;23:265–74.

    Article  PubMed  Google Scholar 

  • Likar R, Kager I, Obmann M, Pipam W, Sittl R. Treatment of localized neuropathic pain after disk herniation with 5% lidocaine medicated plaster. Int J Gen Med. 2012;5:689–92.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liu Y, Feng Y, Zhang T. Pulsed radiofrequency treatment enhances dorsal root ganglion expression of hyperpolarization-activated cyclic nucleotide-gated channels in a rat model of neuropathic pain. J Mol Neurosci. 2015;57:97–105.

    Article  CAS  PubMed  Google Scholar 

  • Magistroni E, Ciclamini D, Panero B, Verna V. Ultrasound-guided pulse-dose radiofrequency: treatment of neuropathic pain after brachial plexus lesion and arm revascularization. Case Rep Med. 2014;2014:429618.

    PubMed  PubMed Central  Google Scholar 

  • Mai J, Franklin G, Tauben D. Guideline for prescribing opioids to treat pain in injured workers. Phys Med Rehabil Clin N Am. 2015;26:453–65.

    Article  PubMed  Google Scholar 

  • Marchand S. Spinal cord stimulation analgesia: substantiating the mechanisms for neuropathic pain treatment. Pain. 2015;156:364–5.

    Article  PubMed  Google Scholar 

  • Moore RA, Wiffen PJ, Derry S, McQuay HJ. Gabapentin for chronic neuropathic pain and fibromyalgia in adults. Cochrane Database Syst Rev. 2011;4:CD007938.

    Google Scholar 

  • Nardone R. Invasive and non-invasive brain stimulation for treatment of neuropathic pain in patients with spinal cord injury: a review. J Spinal Cord Med. 2014;37:19–31.

    Article  PubMed  PubMed Central  Google Scholar 

  • Oosterling A, Te Boveldt N, Verhagen C, van der Graaf WT, et al. Neuropathic pain components in patients with cancer: prevalence, treatment, and interference with daily activities. Pain Pract Cancer. 2015. doi:10.1111/papr.12291.

    Google Scholar 

  • Papangelou A, Radzik BR, Smith T, Gottschalk A. A review of scalp blockade for cranial surgery. J Clin Anesth. 2013;25:150–9.

    Article  PubMed  Google Scholar 

  • Patil PR, Wolfe J, Said Q, Thomas J, Martin BC. Opioid use in the management of diabetic peripheral neuropathy (DPN) in a large commercially insured population. Clin J Pain. 2015;31:414–24.

    Article  PubMed  Google Scholar 

  • Samuel SR, Maiya GA. Application of low frequency and medium frequency currents in the management of acute and chronic pain-a narrative review. Indian J Palliat Care. 2015;21:116–20.

    Article  PubMed  PubMed Central  Google Scholar 

  • Schreiber AK, Nones CF, Reis RC, Chichorro JG, et al. Diabetic neuropathic pain: physiopathology and treatment. World J Diabetes. 2015;6:432–44.

    Article  PubMed  PubMed Central  Google Scholar 

  • Sharma U, Griesing T, Emir B, Young JP. Time to onset of neuropathic pain reduction: a retrospective analysis of data from nine controlled trials of pregabalin for painful diabetic peripheral neuropathy and postherpetic neuralgia. Am J Ther. 2010;17:577–85.

    Article  PubMed  Google Scholar 

  • Smith EM, Bridges GM, Kanawa G, Knoetl R, et al. Cancer treatment-related neuropathic pain syndromes--epidemiology and treatment: an update. Curr Pain Headache Rep. 2014;18:459.

    Article  PubMed  Google Scholar 

  • Sokal P. Motor cortex stimulation in patients with chronic central pain. Adv Clin Exp Med. 2015;24:289–96.

    Article  PubMed  Google Scholar 

  • Souzdalnitski D, Halaszynski TM, Faclier G. Regional anesthesia and co-existing chronic pain. Curr Opin Anaesthesiol. 2010;23:662–70.

    Article  PubMed  Google Scholar 

  • Wettermark B, Brandt L, Kieler H, Boden R. Pregabalin is increasingly prescribed for neuropathic pain, generalised anxiety disorder and epilepsy but many patients discontinue treatment. Int J Clin Pract. 2014;68:104–10.

    Article  CAS  PubMed  Google Scholar 

  • Wilkes D. Programmable intrathecal pumps for the management of chronic pain: recommendations for improved efficiency. J Pain Res. 2014;7:571–7.

    Article  PubMed  PubMed Central  Google Scholar 

  • Xu B, Descalzi G, Ye HR, Zhuo M, Wang YW. Translational investigation and treatment of neuropathic pain. Mol Pain. 2012;8:15.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhang TC, Janik JJ, Grill WM. Mechanisms and models of spinal cord stimulation for the treatment of neuropathic pain. Brain Res. 2014;1569:19–31.

    Article  CAS  PubMed  Google Scholar 

  • Zis P, Apsokardos A, Isaia C, Sykioti P, Vadalouca A. Posttraumatic and postsurgical neuropathic pain responsive to treatment with capsaicin 8% topical patch. Pain Physician. 2014;17:E213–8.

    PubMed  Google Scholar 

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Author notes

    Authors and Affiliations

    1. Department of Anesthesiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China

      Li Xu, Yuguan Zhang & Yuguang Huang

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    1. Li Xu
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    2. Yuguan Zhang
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    3. Yuguang Huang
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    Correspondence to Yuguang Huang .

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    Editors and Affiliations

    1. Dep of Anatomy,Histology and Embryology, Inst of Basic Med Sci Neroscien Cntr, Beijing, China

      Chao Ma

    2. Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, China

      Yuguang Huang

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    © 2016 Springer Science+Business Media Dordrecht

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    Xu, L., Zhang, Y., Huang, Y. (2016). Advances in the Treatment of Neuropathic Pain. In: Ma, C., Huang, Y. (eds) Translational Research in Pain and Itch. Advances in Experimental Medicine and Biology, vol 904. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-7537-3_9

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