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Head and Neck Cancers

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Translation and Its Regulation in Cancer Biology and Medicine

Abstract

Recent evidence suggests that dysregulated translation and its control significantly contribute to the etiology and pathogenesis of the head and neck cancers, specifically to that of squamous cell carcinoma (HNSCC). eIF4E is one of the most studied components of the translation machinery implicated in the development and progression of HNSCC. It appears that dysregulation of eIF4E levels and activity, namely by the PI3K/AKT/mTOR pathway, plays an important role in the etiology and pathogenesis of HNSCC and correlates with clinical outcomes. In this chapter, we will discuss the role of eIF4E and some other translation factors as they relate to the biology and treatment of HNSCC.

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Acknowledgments

This work was supported by the National Institute of Health Grant R01CA102363 (to C.O.N.).

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Authors and Affiliations

  1. Department of Otolaryngology, Head and Neck Surgery and Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center—Shreveport, Shreveport, LA, USA

    Cherie-Ann O. Nathan, Oleksandr Ekshyyan & Arunkumar Anandharaj

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  1. Cherie-Ann O. Nathan
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  2. Oleksandr Ekshyyan
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  3. Arunkumar Anandharaj
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Correspondence to Cherie-Ann O. Nathan .

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Editors and Affiliations

  1. Surgery, McGill University, Montreal, Québec, Canada

    Armen Parsyan

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Nathan, CA., Ekshyyan, O., Anandharaj, A. (2014). Head and Neck Cancers. In: Parsyan, A. (eds) Translation and Its Regulation in Cancer Biology and Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9078-9_25

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