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Other Body Fluids as Non-invasive Sources of Cell-Free DNA/RNA

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Circulating Nucleic Acids in Early Diagnosis, Prognosis and Treatment Monitoring

Part of the book series: Advances in Predictive, Preventive and Personalised Medicine ((APPPM,volume 5))

Abstract

In addition to plasma and serum as sources of nucleic acids circulating in the whole body, amniotic fluid, saliva, urine, pleural effusion, bronchial lavage, bronchial aspirates, breast milk, colostrums, tears, seminal fluid, peritoneal fluid, pleural effusion and stools are all available for minimally invasive analysis of nucleic acids. This chapter introduces the possibilities of using nucleic acids from amniotic fluid, saliva, urine, cerebrospinal fluid and bronchial lavage/aspirates in attempts to produce reliable early markers for diagnosis, prognosis and treatment monitoring using minimally invasive methodology. Moreover, the data from amniotic fluid can be used also to further the understanding of normal and abnormal fetal development in utero. In addition, the data from saliva can be employed for monitoring the progress of premature born infants.

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Authors and Affiliations

  1. Department of Perinatal Medicine, Mercy Hospital for Women, Heidelberg, VIC, Australia

    Lisa Hui

  2. Department of Pediatrics, The Floating Hospital for Children at Tufts Medical Center, Boston, MA, 02111, USA

    Jill L. Maron

  3. Department of Anatomy & Human Sciences, King’s College London, London Bridge, London, SE1 1UL, UK

    Peter B. Gahan

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  1. Lisa Hui
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  2. Jill L. Maron
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  3. Peter B. Gahan
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Correspondence to Peter B. Gahan .

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  1. Anatomy & Human Sciences, King's College London, London, United Kingdom

    Peter B. Gahan

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Hui, L., Maron, J.L., Gahan, P.B. (2015). Other Body Fluids as Non-invasive Sources of Cell-Free DNA/RNA. In: Gahan, P. (eds) Circulating Nucleic Acids in Early Diagnosis, Prognosis and Treatment Monitoring. Advances in Predictive, Preventive and Personalised Medicine, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9168-7_11

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