Abstract
Glaucoma is a neurodegenerative disease, characterized by the progressive death of retinal ganglion cells. Elevated intraocular pressure (IOP) is known to be an important risk factor for glaucoma; however, it is not the only force acting on the optic nerve. Intracranial pressure (ICP) also exerts an effect on the optic nerve head, effectively opposing the force applied by IOP. Indeed, this balance of forces creates a pressure gradient (or the translaminar pressure gradient) across the optic nerve head [1]. Increasingly it is thought that the pressure difference between IOP and ICP, the translaminar pressure (TLP), may be critical for the integrity of the retina and optic nerve [2], and thus ICP may be an important risk factor for glaucoma [2–6].
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Morgan WH, et al. The correlation between cerebrospinal fluid pressure and retrolaminar tissue pressure. Invest Ophthalmol Vis Sci. 1998;39:1419.
Berdahl JP, Allingham RR. Intracranial pressure and glaucoma. Curr Opin Ophthalmol. 2010;21:106.
Jonas JB, et al. Intracranial pressure and glaucoma. J Glaucoma. 2013;22(Suppl 5):S13.
Pasquale LR. Low intracranial pressure: a tipping point in our understanding of primary open-angle glaucoma? Ophthalmology. 2008;115:761.
Siaudvytyte L, et al. Update in intracranial pressure evaluation methods and translaminar pressure gradient role in glaucoma. Acta Ophthalmol. 2015;93:9.
Wostyn P, et al. Are intracranial pressure fluctuations important in glaucoma? Med Hypotheses. 2011;77:598.
Morgan WH, et al. Optic disc movement with variations in intraocular and cerebrospinal fluid pressure. Invest Ophthalmol Vis Sci. 2002;43:3236.
Zhao D, et al. The effect of intraocular and intracranial pressure on retinal structure and function in rats. Physiol Rep. 2015;3(8):2904–6.
He Z, et al. Blood pressure modifies retinal susceptibility to intraocular pressure elevation. PLoS One. 2012;7:e31104.
Bui BV, Fortune B. Ganglion cell contributions to the rat full-field electroretinogram. J Physiol. 2004;555:153.
Yang D, et al. Optic neuropathy induced by experimentally reduced cerebrospinal fluid pressure in monkeys. Invest Ophthalmol Vis Sci. 2014;55:3067.
Berdahl JP, et al. Cerebrospinal fluid pressure is decreased in primary open-angle glaucoma. Ophthalmology. 2008;115:763.
Ren R, et al. Cerebrospinal fluid pressure in glaucoma: a prospective study. Ophthalmology. 2010;117:259.
Wang N, et al. Orbital cerebrospinal fluid space in glaucoma: the Beijing intracranial and intraocular pressure (iCOP) study. Ophthalmology. 2012;119:2065.
Ren R, et al. Cerebrospinal fluid pressure in ocular hypertension. Acta Ophthalmol. 2011;89:e142.
Ren R, et al. Trans-lamina cribrosa pressure difference correlated with neuroretinal rim area in glaucoma. Graefes Arch Clin Exp Ophthalmol. 2011;249:1057.
Acknowledgement
Research Collaboration Grant 501098, University of Melbourne (CTON, BVB, ZH, AJV). National Health and Medical Research Council (NHMRC) Grants 1046203 (BVB, AJV), Melbourne Neuroscience Institute Fellowship (CTON).
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Zhao, D. et al. (2019). Response of the Rat Optic Nerve to Acute Intraocular and Intracranial Pressure Changes. In: Wang, N. (eds) Intraocular and Intracranial Pressure Gradient in Glaucoma. Advances in Visual Science and Eye Diseases, vol 1. Springer, Singapore. https://doi.org/10.1007/978-981-13-2137-5_21
Download citation
DOI: https://doi.org/10.1007/978-981-13-2137-5_21
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-13-2136-8
Online ISBN: 978-981-13-2137-5
eBook Packages: MedicineMedicine (R0)