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Role of Monoamine Oxidases in Heart Diseases

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Modulation of Oxidative Stress in Heart Disease

Abstract

Monoamine oxidases (MAOs) are flavoenzymes that metabolize biogenic amines, dietary amines, and catecholamines in the brain and peripheral tissues. While MAOs are known to contribute to psychiatric and neurodegenerative (Parkinson’s and Alzheimer’s) diseases for a long time, recent studies have established their role in heart diseases as these enzymes potently generate reactive oxygen species (ROS) in cardiomyocytes via oxidative deamination of mainly norepinephrine and serotonin. Indeed, MAOs have emerged as important regulators of mitochondrial/endothelial/cardiac dysfunction, essential hypertension, ventricular hypertrophy, myocardial infarction, cardiomyocyte apoptosis, postischemic cardiac damage, and heart failure. Transcriptional and posttranscriptional regulation of MAOs (via certain transcription factors or microRNAs) may emerge as new therapeutic strategies for treatment of cardiovascular pathological conditions. The next-generation MAO inhibitors (that do not cause irreversible inhibition of MAOs) may also be useful for management of cardiovascular disease states involving dysregulated expression/activity of MAOs.

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Acknowledgments

The authors are thankful to the researchers who contributed to studies on the monoamine oxidases. This work was supported by a grant from the Department of Biotechnology, Government of India, to NRM (project number: BT/PR5017/MED/30/756/2012). VG and VA received research fellowships from the Ministry of Human Resource Development, Government of India, and Department of Science and Technology, Government of India, respectively.

Conflict of Interest Statement

The authors declare that there is no conflict of interest.

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  1. Vinayak Gupta

    Present address: Department of Biotechnology, Bennett University, Greater Noida, Uttar Pradesh, India

Authors and Affiliations

  1. Cardiovascular Genetics Laboratory, Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, Tamil Nadu, India

    Vinayak Gupta, Vikas Arige & Nitish R. Mahapatra

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  1. Vinayak Gupta
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  2. Vikas Arige
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  3. Nitish R. Mahapatra
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Correspondence to Nitish R. Mahapatra .

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Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Institute of Cardiovascular Science, St. Boniface Hospital Research Centre, Winnipeg, MB, Canada

    Naranjan S. Dhalla

  3. Translational Health Science and Technology Institute, Faridabad, Haryana, India

    Madhu Dikshit

  4. Translational Health Science and Technology Institute, Faridabad, Haryana, India

    Nirmal K. Ganguly

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Gupta, V., Arige, V., Mahapatra, N.R. (2019). Role of Monoamine Oxidases in Heart Diseases. In: Chakraborti, S., Dhalla, N., Dikshit, M., Ganguly, N. (eds) Modulation of Oxidative Stress in Heart Disease. Springer, Singapore. https://doi.org/10.1007/978-981-13-8946-7_6

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