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iPS Cell and Renal Regenerative Medicine

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Acute Kidney Injury and Regenerative Medicine

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Abstract

Recent progress in kidney regeneration research using induced pluripotent stem (iPS) cells has enabled the induction of nephron progenitor cells (NPCs) and the reconstruction of kidney organoids that include nephron structures in vitro. In this article, we first explain the history of iPS cells and kidney regeneration research. Next, we summarize the current status of cell therapies including the mechanisms of action using human iPS cell-derived NPCs against kidney diseases, such as acute kidney injury (AKI). These therapies would benefit from the development of expansion cultures and purification methods for NPCs. Finally, we discuss the future perspectives of cell therapies and other possible applications using human iPS cell-derived NPCs against kidney diseases.

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Acknowledgment

The authors would like to thank Dr. Peter Karagiannis, CiRA, Kyoto University, for critically reading and revising the manuscript. The research of authors is supported by the Japan Agency for Medical Research and Development (AMED) through its research grant “Core Center for iPS Cell Research and The Acceleration Program for Intractable Diseases Research utilizing Disease-specific iPS cells, Research Center Network for Realization of Regenerative Medicine” and “Practical Research Project for Rare/Intractable Diseases” to K.O., and the JSPS Grants-in-Aid for Scientific Research (B) 18H02826 for K.O. and for Scientific Research (C) 18K07043 for T.A.

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Authors and Affiliations

  1. Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan

    Toshikazu Araoka & Kenji Osafune

Authors
  1. Toshikazu Araoka
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  2. Kenji Osafune
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Corresponding author

Correspondence to Kenji Osafune .

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Editors and Affiliations

  1. Department of Endocrinology, Metabolism, and Nephrology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan

    Yoshio Terada

  2. Department of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan

    Takashi Wada

  3. Department of Acute Medicine, The University of Tokyo, Tokyo, Japan

    Kent Doi

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Araoka, T., Osafune, K. (2020). iPS Cell and Renal Regenerative Medicine. In: Terada, Y., Wada, T., Doi, K. (eds) Acute Kidney Injury and Regenerative Medicine . Springer, Singapore. https://doi.org/10.1007/978-981-15-1108-0_24

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  • DOI: https://doi.org/10.1007/978-981-15-1108-0_24

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-15-1107-3

  • Online ISBN: 978-981-15-1108-0

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