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Tissue Engineering Strategies for Tooth and Dento-alveolar Region with Engineered Biomaterial and Stem Cells

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Biointerface Engineering: Prospects in Medical Diagnostics and Drug Delivery

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Abstract

This chapter summarizes the progress made in the therapeutic application of adult multipotent stem cells, in conjunction with biomaterials for regeneration of whole tooth and associated structures. The management of edentulous space and alveolar bone resorption, following extraction of tooth or periodontal pathology, represents a major challenge in clinical dentistry. Additionally, the precise role of surface topography and its chemical constituents for dental implants in the dynamics of osseointegration and alveolar bone regeneration (used for replacing those missing teeth) remains poorly understood. Hence, a broader therapeutic strategy, involving interdisciplinary knowledge-based approach from scientist to clinicians, is essential for the development of engineered nanostructure biomaterials with exogenous or endogenous mesenchymal stem cells for translating the evolved cross-disciplinary concepts into clinical application and products.

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References

  • Abdulqader ST, Ab Rahman I, Ismail H, Kannan TP, Mahmood Z (2013) A simple pathway in preparation of controlled porosity of biphasic calcium phosphate scaffold for dentin regeneration. Ceram Int 39:2375–2381

    CAS  Google Scholar 

  • About I, Bottero M-J, De Denato P, Camps J, Franquin J-C, Mitsiadis TA (2000) Human dentin production in vitro. Exp Cell Res 258:33–41

    CAS  PubMed  Google Scholar 

  • Adell R, Lekholm U, Rockler B, BrÃ¥nemark P-I (1981) A 15-year study of Osseointegrated implants in the treatment of the edentulous jaw. Int J Oral Surg 10:387–416

    CAS  PubMed  Google Scholar 

  • Adell R, Eriksson B, Lekholm U, BrÃ¥nemark P-I, Jemt T (1990) A Long-term follow-up study of Osseointegrated implants in the treatment of totally edentulous jaws. Int J Oral Max Impl 5:347–359

    CAS  Google Scholar 

  • Ahangari Z, Naseri M, Jalili M, Mansouri Y, Mashhadiabbas F, Torkaman A (2012) Effect of Propolis on dentin regeneration and the potential role of dental pulp stem cell in Guinea pigs. Cell J (Yakhteh) 13:223

    Google Scholar 

  • Akizuki T, Oda S, Komaki M, Tsuchioka H, Kawakatsu N, Kikuchi A, Yamato M, Okano T, Ishikawa I (2005) Application of periodontal ligament cell sheet for periodontal regeneration: A pilot study in beagle dogs. J Periodontal Res 40:245–251

    PubMed  Google Scholar 

  • Anil S, Anand P, Alghamdi H, Jansen J (2011) Dental implant surface enhancement and Osseointegration. Implant Dentistry-A Rapidly Evolving Practice, Intech

    Google Scholar 

  • Arrington ED, Smith WJ, Chambers HG, Bucknell AL, Davino NA (1996) Complications of iliac crest bone graft harvesting. Clin Orthop Relat Res 329:300–309

    Google Scholar 

  • Artzi Z, Nemcovsky CE (1998) The application of Deproteinized bovine bone mineral for ridge preservation prior to implantation. Clinical and histological observations in a case report. J Periodontol 69:1062–1067

    CAS  PubMed  Google Scholar 

  • Atwood DA (1971) Reduction of residual ridges: A Major Oral disease entity. J Prosthet Dent 26:266–279

    CAS  PubMed  Google Scholar 

  • Baranowska-Korczyc A, Warowicka A, Jasiurkowska-Delaporte M, GrzeÅ›kowiak B, Jarek M, Maciejewska BM, Jurga-Stopa J, Jurga S (2016) Antimicrobial electrospun poly (Ε-Caprolactone) scaffolds for gingival fibroblast growth. RSC Adv 6:19647–19656

    CAS  Google Scholar 

  • Bartold PM, Mcculloch CA, Narayanan AS, Pitaru S (2000) Tissue engineering: A new paradigm for periodontal regeneration based on molecular and cell biology. Periodontology 2000(24):253–269

    Google Scholar 

  • Bosshardt DD, Sculean A (2009) Does periodontal tissue regeneration really work? Periodontology 2000(51):208–219

    Google Scholar 

  • Bottino MC, Thomas V, Schmidt G, Vohra YK, Chu T-MG, Kowolik MJ, Janowski GM (2012) Recent advances in the development of Gtr/Gbr membranes for periodontal regeneration – a materials perspective. Dent Mater 28:703–721

    CAS  PubMed  Google Scholar 

  • Bruder SP, Kraus KH, Goldberg VM, Kadiyala S (1998a) The effect of implants loaded with autologous Mesenchymal stem cells on the healing of canine segmental bone defects. JBJS 80:985–996

    CAS  Google Scholar 

  • Bruder SP, Kurth AA, Shea M, Hayes WC, Jaiswal N, Kadiyala S (1998b) Bone regeneration by implantation of purified, culture-expanded human Mesenchymal stem cells. J Orthop Res 16:155–162

    CAS  PubMed  Google Scholar 

  • Brunsvold MA, Mellonig JT (1993) Bone grafts and periodontal regeneration. Periodontology 2000(1):80–91

    Google Scholar 

  • Buser D, Warrer K, Karring T (1990) Formation of a periodontal ligament around titanium implants. J Periodontol 61:597–601

    CAS  PubMed  Google Scholar 

  • Buurma B, Gu K, Rutherford RB (1999) Transplantation of human pulpal and gingival fibroblasts attached to synthetic scaffolds. Eur J Oral Sci 107:282–289

    CAS  PubMed  Google Scholar 

  • Carr AB, Brown DT (2010) Mccracken’s removable partial prosthodontics-E-book. Elsevier Health Sciences, London

    Google Scholar 

  • Caton J, Nyman S (1980) Histometric evaluation of periodontal surgery I. the modified Widman flap procedure. J Clin Periodontol 7:212–223

    CAS  PubMed  Google Scholar 

  • Caton J, Nyman S, Zander H (1980) Histometric evaluation of periodontal surgery ii. Connective tissue attachment levels after four regenerative procedures. J Clin Periodontol 7:224–231

    CAS  PubMed  Google Scholar 

  • Cawood J, Howell R (1991) Reconstructive Preprosthetic surgery: I. anatomical considerations. Int J Oral Max Surg 20:75–82

    CAS  Google Scholar 

  • Chai C, Leong KW (2007) Biomaterials approach to expand and direct differentiation of stem cells. Mol Ther 15:467–480

    CAS  PubMed  PubMed Central  Google Scholar 

  • Chang H-H, Wang Y-L, Chiang Y-C, Chen Y-L, Chuang Y-H, Tsai S-J, Heish K-H, Lin F-H, Lin C-P (2014) A novel chitosan-Γpga polyelectrolyte complex hydrogel promotes early new bone formation in the alveolar socket following tooth extraction. PLoS One 9:E92362

    PubMed  PubMed Central  Google Scholar 

  • Chen G, Chen J, Yang B, Li L, Luo X, Zhang X, Feng L, Jiang Z, Yu M, Guo W (2015) Combination of aligned Plga/gelatin electrospun sheets, native dental pulp extracellular matrix and treated dentin matrix as substrates for tooth root regeneration. Biomaterials 52:56–70

    CAS  PubMed  Google Scholar 

  • Choi B-H (2000) Periodontal ligament formation around titanium implants using cultured periodontal ligament cells: A pilot study. Int J Oral Max Impl 15:193–196

    CAS  Google Scholar 

  • Christgau NM, Bader N, Schmalz G, Hiller KA, Wenzel A (1998) Gtr therapy of Intrabony defects using 2 different Bioresorbable membranes: 12-month results. J Clin Periodontol 25:499–509

    CAS  PubMed  Google Scholar 

  • Cochran DL (2008) Inflammation and bone loss in periodontal disease. J Periodontol 79:1569–1576

    CAS  PubMed  Google Scholar 

  • D’aquino R, De Rosa A, Lanza V, Tirino V, Laino L, Graziano A, Desiderio V, Laino G, Papaccio G (2009) Human mandible bone defect repair by the grafting of dental pulp stem/progenitor cells and collagen sponge biocomplexes. Eur Cell Mater 18:75–83

    PubMed  Google Scholar 

  • Darby IB, Morris KH (2013) A systematic review of the use of growth factors in human periodontal regeneration. J Periodontol 84:465–476

    CAS  PubMed  Google Scholar 

  • Darby I, Chen ST, Buser D (2009) Ridge preservation techniques for implant therapy. Int J Oral Max Impl 24:260–271

    Google Scholar 

  • Das, S. & Bellare, J. R. 2018. Dental pulp stem cells in customized 3d Nanofibrous scaffolds for regeneration of peripheral nervous system

    Google Scholar 

  • Das S, Gurav S, Soni V, Ingle A, Mohanty BS, Chaudhari P, Bendale K, Dholam K, Bellare JR (2018) Osteogenic Nanofibrous coated titanium implant results in enhanced Osseointegration: In vivo preliminary study in a rabbit model. Tissue Eng Regen Med 15:231–247

    CAS  PubMed  PubMed Central  Google Scholar 

  • De Groot K, Geesink R, Klein C, Serekian P (1987) Plasma sprayed coatings of Hydroxylapatite. J Biomed Mater Res 21:1375–1381

    PubMed  Google Scholar 

  • Dhandayuthapani B, Yoshida Y, Maekawa T, Kumar DS (2011) Polymeric scaffolds in tissue engineering application: A review. Int J Polym Sci 2011:1–19

    Google Scholar 

  • Dimitriou R, Mataliotakis GI, Angoules AG, Kanakaris NK, Giannoudis PV (2011) Complications following autologous bone graft harvesting from the iliac crest and using the Ria: A systematic review. Injury 42:S3–S15

    PubMed  Google Scholar 

  • Dobie K, Smith G, Sloan A, Smith A (2002) Effects of alginate hydrogels and Tgf-Î’1 on human dental pulp repair in vitro. Connect Tissue Res 43:387–390

    CAS  PubMed  Google Scholar 

  • Dong J-K, Jin T-H, Cho H-W, Oh S-C (1999) The esthetics of the smile: A review of some recent studies. Int J Prosthodont 12:9–19

    CAS  PubMed  Google Scholar 

  • Duailibi MT, Duailibi SE, Young CS, Bartlett JD, Vacanti JP, Yelick PC (2004) Bioengineered teeth from cultured rat tooth bud cells. J Dent Res 83:523–528

    CAS  PubMed  Google Scholar 

  • Duailibi S, Duailibi M, Zhang W, Asrican R, Vacanti J, Yelick P (2008) Bioengineered dental tissues grown in the rat jaw. J Dent Res 87:745–750

    CAS  PubMed  PubMed Central  Google Scholar 

  • Dye BA, Thornton-Evans G, Li X, Iafolla T (2015) Dental caries and tooth loss in adults in the United States, 2011–2012. Us Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics, Hyattsville, MD

    Google Scholar 

  • Edman K, Öhrn K, Nordström B, Holmlund A, Hellberg D (2015) Trends over 30 years in the prevalence and severity of alveolar bone loss and the influence of smoking and socio-economic factors–based on epidemiological surveys in Sweden 1983–2013. Int J Dent Hyg 13:283–291

    CAS  PubMed  Google Scholar 

  • Egusa H, Sonoyama W, Nishimura M, Atsuta I, Akiyama K (2012) Stem cells in dentistry–part II: Clinical applications. J Prosthodont Res 56:229–248

    PubMed  Google Scholar 

  • El-Backly RM, Massoud AG, El-Badry AM, Sherif RA, Marei MK (2008) Regeneration of dentine/pulp-like tissue using a dental pulp stem cell/poly (lactic-co-glycolic) acid scaffold construct in New Zealand white rabbits. Aust Endod J 34:52–67

    PubMed  Google Scholar 

  • Ellingsen JE, Johansson CB, Wennerberg A, Holmén A (2004) Improved retention and bone-to-implant contact with fluoride-modified titanium implants. Int J Oral Max Impl 19:659–666

    Google Scholar 

  • Elsharkawy S, Mata A (2018) Hierarchical biomineralization: From Nature’s designs to synthetic materials for regenerative medicine and dentistry. Adv Healthc Mater 7:1800178

    Google Scholar 

  • Elsharkawy S, Al-Jawad M, Pantano MF, Tejeda-Montes E, Mehta K, Jamal H, Agarwal S, Shuturminska K, Rice A, Tarakina NV (2018) Protein disorder–order interplay to guide the growth of hierarchical mineralized structures. Nat Commun 9:2145

    PubMed  PubMed Central  Google Scholar 

  • Emami E, De Souza RF, Kabawat M, Feine JS (2013) The impact of Edentulism on Oral and general health. Int J Dent 2013:1–7

    Google Scholar 

  • Flores MG, Hasegawa M, Yamato M, Takagi R, Okano T, Ishikawa I (2008) Cementum–periodontal ligament complex regeneration using the cell sheet technique. J Periodontal Res 43:364–371

    CAS  PubMed  Google Scholar 

  • Gault P, Black A, Romette JL, Fuente F, Schroeder K, Thillou F, Brune T, Berdal A, Wurtz T (2010) Tissue-engineered ligament: Implant constructs for tooth replacement. J Clin Periodontol 37:750–758

    PubMed  Google Scholar 

  • Ghi H, Mcgivney GP (1979) Influence of tooth proprioception on speech articulation. J Prosthet Dent 42:609–613

    CAS  PubMed  Google Scholar 

  • Giannoudis PV, Dinopoulos H, Tsiridis E (2005) Bone substitutes: An update. Injury 36:S20–S27

    PubMed  Google Scholar 

  • Gottlow J, Nyman S, Lindhe J, Karring T, Wennström J (1986) New attachment formation in the human Periodontium by guided tissue regeneration case reports. J Clin Periodontol 13:604–616

    CAS  PubMed  Google Scholar 

  • Gronthos S, Mankani M, Brahim J, Robey PG, Shi S (2000) Postnatal human dental pulp stem cells (Dpscs) in vitro and in vivo. Proc Natl Acad Sci 97:13625–13630

    CAS  PubMed  Google Scholar 

  • Gronthos S, Brahim J, Li W, Fisher L, Cherman N, Boyde A, Denbesten P, Robey PG, Shi S (2002) Stem cell properties of human dental pulp stem cells. J Dent Res 81:531–535

    CAS  PubMed  Google Scholar 

  • Guarnieri R, Giardino L, Crespi R, Romagnoli R (2002) Cementum formation around a titanium implant: A case report. Int J Oral Max Impl 17:729–732

    Google Scholar 

  • Guo W, He Y, Zhang X, Lu W, Wang C, Yu H, Liu Y, Li Y, Zhou Y, Zhou J (2009) The use of dentin matrix scaffold and dental follicle cells for dentin regeneration. Biomaterials 30:6708–6723

    CAS  PubMed  Google Scholar 

  • Guo W, Gong K, Shi H, Zhu G, He Y, Ding B, Wen L, Jin Y (2012) Dental follicle cells and treated dentin matrix scaffold for tissue engineering the tooth root. Biomaterials 33:1291–1302

    CAS  PubMed  Google Scholar 

  • Gupta D, Singh AK, Dravid A, Bellare JR (2019) Multiscale porosity in compressible cryogenically 3d printed gel for bone tissue engineering. ACS Appl Mater Interfaces 11:20437–20452

    CAS  PubMed  Google Scholar 

  • Hall WB (2013) Hall’s critical decisions in periodontology and dental Implantology. Pmph-USA, Shelton, CT

    Google Scholar 

  • Hämmerle CH, Jung RE (2003) Bone augmentation by means of barrier membranes. Periodontology 2000(33):36–53

    Google Scholar 

  • Hämmerle CH, Araújo MG, Simion M, Group OC (2012) Evidence-based knowledge on the biology and treatment of extraction sockets. Clin Oral Impl Res 23:80–82

    Google Scholar 

  • Hasan A, Waibhaw G, Tiwari S, Dharmalingam K, Shukla I, Pandey LM (2017) Fabrication and characterization of chitosan, Polyvinylpyrrolidone, and cellulose Nanowhiskers Nanocomposite films for wound healing drug delivery application. J Biomed Mater Res A 105:2391–2404

    CAS  PubMed  Google Scholar 

  • Hasan A, Pattanayek SK, Pandey LM (2018a) Effect of functional groups of self-assembled monolayers on protein adsorption and initial cell adhesion. ACS Biomater Sci Eng 4:3224–3233

    CAS  Google Scholar 

  • Hasan A, Saxena V, Pandey LM (2018b) Surface functionalization of Ti6al4v via self-assembled monolayers for improved protein adsorption and fibroblast adhesion. Langmuir 34:3494–3506

    CAS  PubMed  Google Scholar 

  • Hasan A, Waibhaw G, Saxena V, Pandey LM (2018c) Nano-biocomposite scaffolds of chitosan, Carboxymethyl cellulose and silver nanoparticle modified cellulose Nanowhiskers for bone tissue engineering applications. Int J Biol Macromol 111:923–934

    CAS  PubMed  Google Scholar 

  • Hasegawa M, Yamato M, Kikuchi A, Okano T, Ishikawa I (2005) Human periodontal ligament cell sheets can regenerate periodontal ligament tissue in an Athymic rat model. Tissue Eng 11:469–478

    CAS  PubMed  Google Scholar 

  • Hasturk H, Kantarci A, Ghattas M, Dangaria SJ, Abdallah R, Morgan EF, Diekwisch TG, Ashman A, Van Dyke T (2014) The use of light/chemically hardened Polymethylmethacrylate, Polyhydroxylethylmethacrylate, and calcium hydroxide graft material in combination with Polyanhydride around implants and extraction sockets in Minipigs: Part II: Histologic and micro-Ct evaluations. J Periodontol 85:1230–1239

    CAS  PubMed  PubMed Central  Google Scholar 

  • Helkimo E, Carlsson GE, Helkimo M (1977) Bite force and state of dentition. Acta Odontol Scand 35:297–303

    CAS  PubMed  Google Scholar 

  • Holtgrave E, Donath K (1995) Response of Odontoblast-like cells to hydroxyapatite ceramic granules. Biomaterials 16:155–159

    CAS  PubMed  Google Scholar 

  • Honda MJ, Ohara T, Sumita Y, Ogaeri T, Kagami H, Ueda M (2006) Preliminary study of tissue-engineered Odontogenesis in the canine jaw. J Oral Max Surg 64:283–289

    Google Scholar 

  • Horváth A, Mardas N, Mezzomo LA, Needleman IG, Donos N (2013) Alveolar ridge preservation. A systematic review. Clin Oral Investig 17:341–363

    PubMed  Google Scholar 

  • Howell TH, Fiorellini JP, Paquette DW, Offenbacher S, Giannobile WV, Lynch SE (1997) A phase I/II clinical trial to evaluate a combination of recombinant human platelet-derived growth factor-bb and recombinant human insulin-like growth factor-I in patients with periodontal disease. J Periodontol 68:1186–1193

    CAS  PubMed  Google Scholar 

  • Huang GT-J, Yamaza T, Shea LD, Djouad F, Kuhn NZ, Tuan RS, Shi S (2009) Stem/progenitor cell–mediated De novo regeneration of dental pulp with newly deposited continuous layer of dentin in an in vivo model. Tissue Eng Part A 16:605–615

    PubMed Central  Google Scholar 

  • Huang GTJ, Al-Habib M, Gauthier P (2013) Challenges of stem cell-based pulp and dentin regeneration: A clinical perspective. Endod Top 28:51–60

    Google Scholar 

  • Hutmacher D, Goh J, Teoh S (2001) An introduction to biodegradable materials for tissue engineering applications. Ann Acad Med Singap 30:183–191

    CAS  PubMed  Google Scholar 

  • Ikeda E, Morita R, Nakao K, Ishida K, Nakamura T, Takano-Yamamoto T, Ogawa M, Mizuno M, Kasugai S, Tsuji T (2009) Fully functional bioengineered tooth replacement as an organ replacement therapy. Proc Natl Acad Sci 106:13475–13480

    CAS  PubMed  Google Scholar 

  • Iohara K, Nakashima M, Ito M, Ishikawa M, Nakasima A, Akamine A (2004) Dentin regeneration by dental pulp stem cell therapy with recombinant human bone morphogenetic protein 2. J Dent Res 83:590–595

    CAS  PubMed  Google Scholar 

  • Iohara K, Imabayashi K, Ishizaka R, Watanabe A, Nabekura J, Ito M, Matsushita K, Nakamura H, Nakashima M (2011) Complete pulp regeneration after Pulpectomy by transplantation of Cd105+ stem cells with stromal cell-derived Factor-1. Tissue Eng Part A 17:1911–1920

    CAS  PubMed  Google Scholar 

  • Ishimatsu H, Kitamura C, Morotomi T, Tabata Y, Nishihara T, Chen K-K, Terashita M (2009) Formation of dentinal bridge on surface of regenerated dental pulp in dentin defects by controlled release of fibroblast growth factor–2 from gelatin hydrogels. J Endod 35:858–865

    PubMed  Google Scholar 

  • Ishimoto K, Hayano S, Yanagita T, Kurosaka H, Kawanabe N, Itoh S, Ono M, Kuboki T, Kamioka H, Yamashiro T (2015) Topical application of lithium chloride on the pulp induces dentin regeneration. PLoS One 10:E0121938

    PubMed  PubMed Central  Google Scholar 

  • Iwata T, Yamato M, Tsuchioka H, Takagi R, Mukobata S, Washio K, Okano T, Ishikawa I (2009) Periodontal regeneration with multi-layered periodontal ligament-derived cell sheets in a canine model. Biomaterials 30:2716–2723

    CAS  PubMed  Google Scholar 

  • Jacobs R, Van Steenberghe D (1994) Role of periodontal ligament receptors in the tactile function of teeth: A review. J Periodontal Res 29:153–167

    CAS  PubMed  Google Scholar 

  • Jahangiri L, Hessamfar R, Ricci JL (2005) Partial generation of periodontal ligament on Endosseous dental implants in dogs. Clin Oral Impl Res 16:396–401

    Google Scholar 

  • Jaiswal AK, Dhumal RV, Ghosh S, Chaudhari P, Nemani H, Soni VP, Vanage GR, Bellare JR (2013a) Bone healing evaluation of Nanofibrous composite scaffolds in rat Calvarial defects: A comparative study. J Biomed Nanotechnol 9:2073–2085

    CAS  PubMed  Google Scholar 

  • Jaiswal AK, Kadam SS, Soni VP, Bellare JR (2013b) Improved functionalization of electrospun Plla/gelatin scaffold by alternate soaking method for bone tissue engineering. Appl Surf Sci 268:477–488

    CAS  Google Scholar 

  • Ji B, Sheng L, Chen G, Guo S, Xie L, Yang B, Guo W, Tian W (2014) The combination use of platelet-rich fibrin and treated dentin matrix for tooth root regeneration by cell homing. Tissue Eng Part A 21:26–34

    PubMed  Google Scholar 

  • Jiao L, Xie L, Yang B, Yu M, Jiang Z, Feng L, Guo W, Tian W (2014) Cryopreserved dentin matrix as a scaffold material for dentin-pulp tissue regeneration. Biomaterials 35:4929–4939

    CAS  PubMed  Google Scholar 

  • Jivraj S, Chee W (2006) Rationale for dental implants. Br Dent J 200:661

    CAS  PubMed  Google Scholar 

  • Johnson NC, Sandy JR (1999) Tooth position and speech – is there a relationship? Angle Orthod 69:306–310

    CAS  PubMed  Google Scholar 

  • Karring T, Nyman S, Gottlow J, Laurell L (1993) Development of the biological concept of guided tissue regeneration – animal and human studies. Periodontology 2000(1):26–35

    Google Scholar 

  • Katagiri W, Osugi M, Kawai T, Hibi H (2016) First-in-human study and clinical case reports of the alveolar bone regeneration with the Secretome from human Mesenchymal stem cells. Head Face Med 12:5

    PubMed  PubMed Central  Google Scholar 

  • Kawaguchi H, Hirachi A, Hasegawa N, Iwata T, Hamaguchi H, Shiba H, Takata T, Kato Y, Kurihara H (2004) Enhancement of periodontal tissue regeneration by transplantation of bone marrow Mesenchymal stem cells. J Periodontol 75:1281–1287

    PubMed  Google Scholar 

  • Kenney EB, Ramfjord SP (1969) Patterns of root and alveolar-bone growth associated with development and eruption of teeth in rhesus monkeys. J Dent Res 48:251–256

    CAS  PubMed  Google Scholar 

  • Kim BW (2018) Clinical regenerative medicine in urology. Springer, Singapore

    Google Scholar 

  • Kim H, Choi S-H, Ryu J-J, Koh S-Y, Park J-H, Lee I-S (2008) The biocompatibility of Sla-treated titanium implants. Biomed Mater 3:025011

    PubMed  Google Scholar 

  • Kim NR, Lee DH, Chung P-H, Yang H-C (2009a) Distinct differentiation properties of human dental pulp cells on collagen, gelatin, and chitosan scaffolds. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108:E94–E100

    PubMed  Google Scholar 

  • Kim SH, Kim KH, Seo BM, Koo KT, Kim TI, Seol YJ, Ku Y, Rhyu IC, Chung CP, Lee YM (2009b) Alveolar bone regeneration by transplantation of periodontal ligament stem cells and bone marrow stem cells in a canine Peri-implant defect model: A pilot study. J Periodontol 80:1815–1823

    PubMed  Google Scholar 

  • Komine A, Suenaga M, Nakao K, Tsuji T, Tomooka Y (2007) Tooth regeneration from newly established cell lines from a molar tooth germ epithelium. Biochem Biophys Res Commun 355:758–763

    CAS  PubMed  Google Scholar 

  • Kuo TF, Huang AT, Chang HH, Lin FH, Chen ST, Chen RS, Chou CH, Lin HC, Chiang H, Chen MH (2008) Regeneration of dentin-pulp complex with Cementum and periodontal ligament formation using dental bud cells in gelatin-chondroitin-Hyaluronan tri-copolymer scaffold in swine. J Biomed Mater Res A: An Official Journal of the Society for Biomaterials, the Japanese Society for Biomaterials, and the Australian Society for Biomaterials and the Korean Society for Biomaterials 86:1062–1068

    Google Scholar 

  • Kurth A, Eberhardt C, Müller S, Steinacker M, Schwarz M, Bauss F (2005) The bisphosphonate Ibandronate improves implant integration in Osteopenic Ovariectomized rats. Bone 37:204–210

    CAS  PubMed  Google Scholar 

  • Lang H, Schüler N, Nolden R (1998) Attachment formation following replantation of cultured cells into periodontal defects – a study in Minipigs. J Dent Res 77:393–405

    CAS  PubMed  Google Scholar 

  • Le Guéhennec L, Soueidan A, Layrolle P, Amouriq Y (2007) Surface treatments of titanium dental implants for rapid Osseointegration. Dent Mater 23:844–854

    PubMed  Google Scholar 

  • Lee D-J, Lee J-M, Kim E-J, Takata T, Abiko Y, Okano T, Green DW, Shimono M, Jung H-S (2017) Bio-implant as a novel restoration for tooth loss. Sci Rep 7:7414

    PubMed  PubMed Central  Google Scholar 

  • Lekholm U, Van Steenberghe D, Herrmann I, Bolender C, Folmer T, Gunne J, Henry P, Higuchi K, Laney WR, Lindén U (1994) Osseointegrated implants in the treatment of partially edentulous jaws: A prospective 5-year multicenter study. Int J Oral Max Impl 9:627–635

    Google Scholar 

  • Lekovic V, Camargo PM, Klokkevold PR, Weinlaender M, Kenney EB, Dimitrijevic B, Nedic M (1998) Preservation of alveolar bone in extraction sockets using bioabsorbable membranes. J Periodontol 69:1044–1049

    CAS  PubMed  Google Scholar 

  • Li J, Li Y, Ma S, Gao Y, Zuo Y, Hu J (2010) Enhancement of bone formation by bmp-7 transduced Mscs on biomimetic Nano-hydroxyapatite/polyamide composite scaffolds in repair of mandibular defects. J Biomed Mater Res A 95:973–981

    PubMed  Google Scholar 

  • Li R, Guo W, Yang B, Guo L, Sheng L, Chen G, Li Y, Zou Q, Xie D, An X (2011) Human treated dentin matrix as a natural scaffold for complete human dentin tissue regeneration. Biomaterials 32:4525–4538

    CAS  PubMed  Google Scholar 

  • Lin Y, Gallucci GO, Buser D, Bosshardt D, Belser U, Yelick PC (2011) Bioengineered periodontal tissue formed on titanium dental implants. J Dent Res 90:251–256

    CAS  PubMed  PubMed Central  Google Scholar 

  • Lindquist LW, Rockler B, Carlsson GE (1988) Bone Resorption around fixtures in edentulous patients treated with mandibular fixed tissue-integrated prostheses. J Prosthet Dent 59:59–63

    CAS  PubMed  Google Scholar 

  • Liu Y, Enggist L, Kuffer AF, Buser D, Hunziker EB (2007) The influence of bmp-2 and its mode of delivery on the Osteoconductivity of implant surfaces during the early phase of Osseointegration. Biomaterials 28:2677–2686

    CAS  PubMed  Google Scholar 

  • Liu Y, Zheng Y, Ding G, Fang D, Zhang C, Bartold PM, Gronthos S, Shi S, Wang S (2008) Periodontal ligament stem cell-mediated treatment for periodontitis in miniature swine. Stem Cells 26:1065–1073

    PubMed  PubMed Central  Google Scholar 

  • Lops D, Ferroni L, Gardin C, Ricci S, Guazzo R, Sbricoli L, Romeo E, Calvo-Guirado JL, Bressan E, Zavan B (2014) Osteoproperties of polyethylene glycol hydrogel material. J Osseointegration 6:61–65

    Google Scholar 

  • Luiz De Oliveira Da Rosa W, Machado Da Silva T, Fernando Demarco F, Piva E, Fernandes Da Silva A (2017) Could the application of bioactive molecules improve vital pulp therapy success? A systematic review. J Biomed Mater Res A 105:941–956

    CAS  PubMed  Google Scholar 

  • Marco F, Milena F, Gianluca G, Vittoria O (2005) Peri-implant Osteogenesis in health and osteoporosis. Micron 36:630–644

    CAS  PubMed  Google Scholar 

  • Marei MK, Saad MM, El-Ashwah AM, El-Backly RM, Al-Khodary MA (2009) Experimental formation of periodontal structure around titanium implants utilizing bone marrow Mesenchymal stem cells: A pilot study. J Oral Implantol 35:106–129

    PubMed  Google Scholar 

  • Marin E, Briceño MI, Caballero-George C (2013) Critical evaluation of biodegradable polymers used in Nanodrugs. Int J Nanomedicine 8:3071

    PubMed  PubMed Central  Google Scholar 

  • Mina M, Kollar E (1987) The induction of Odontogenesis in non-dental mesenchyme combined with early murine mandibular arch epithelium. Arch Oral Biol 32:123–127

    CAS  PubMed  Google Scholar 

  • Miron RJ, Sculean A, Cochran DL, Froum S, Zucchelli G, Nemcovsky C, Donos N, Lyngstadaas SP, Deschner J, Dard M (2016) Twenty years of enamel matrix derivative: The past, the present and the future. J Clin Periodontol 43:668–683

    PubMed  Google Scholar 

  • Misch CE (2004) Dental implant prosthetics-E-book. Elsevier Health Sciences, St. Louis, MO

    Google Scholar 

  • Modino SA, Sharpe PT (2005) Tissue engineering of teeth using adult stem cells. Arch Oral Biol 50:255–258

    PubMed  Google Scholar 

  • Mooney DJ, Powell C, Piana J, Rutherford B (1996) Engineering dental pulp-like tissue in vitro. Biotechnol Prog 12:865–868

    CAS  PubMed  Google Scholar 

  • Na S, Zhang H, Huang F, Wang W, Ding Y, Li D, Jin Y (2016) Regeneration of dental pulp/dentine complex with a three-dimensional and scaffold-free stem-cell sheet-derived pellet. J Tissue Eng Regen Med 10:261–270

    CAS  PubMed  Google Scholar 

  • Nair LS, Laurencin CT (2007) Biodegradable polymers as biomaterials. Prog Polym Sci 32:762–798

    CAS  Google Scholar 

  • Nakahara T, Nakamura T, Kobayashi E, Kuremoto K-I, Matsuno T, Tabata Y, Eto K, Shimizu Y (2004) In situ tissue engineering of periodontal tissues by seeding with periodontal ligament-derived cells. Tissue Eng 10:537–544

    CAS  PubMed  Google Scholar 

  • Nakao K, Morita R, Saji Y, Ishida K, Tomita Y, Ogawa M, Saitoh M, Tomooka Y, Tsuji T (2007) The development of a bioengineered organ germ method. Nat Methods 4:227

    CAS  PubMed  Google Scholar 

  • Nakashima M (2005) Bone morphogenetic proteins in dentin regeneration for potential use in endodontic therapy. Cytok Growth Factor Rev 16:369–376

    CAS  Google Scholar 

  • Nakashima M, Iohara K (2017) Recent Progress in translation from bench to a pilot clinical study on Total pulp regeneration. J Endod 43:S82–S86

    PubMed  Google Scholar 

  • Nakashima M, Iohara K, Murakami M, Nakamura H, Sato Y, Ariji Y, Matsushita K (2017) Pulp regeneration by transplantation of dental pulp stem cells in pulpitis: A pilot clinical study. Stem Cell Res Ther 8:61

    PubMed  PubMed Central  Google Scholar 

  • Nanci A (2017) Ten Cate’s Oral histology-E-book: Development, structure, and function. Elsevier Health Sciences, St. Louis, MO

    Google Scholar 

  • O’brien FJ (2011) Biomaterials & Scaffolds for tissue engineering. Mater Today 14:88–95

    Google Scholar 

  • Ohara T, Itaya T, Usami K, Ando Y, Sakurai H, Honda MJ, Ueda M, Kagami H (2010) Evaluation of scaffold materials for tooth tissue engineering. J Biomed Mater Res A 94:800–805

    PubMed  Google Scholar 

  • Ohazama A, Modino S, Miletich I, Sharpe P (2004) Stem-cell-based tissue engineering of murine teeth. J Dent Res 83:518–522

    CAS  PubMed  Google Scholar 

  • Ong G (1998) Periodontal disease and tooth loss. Int Dent J 48:233–238

    CAS  PubMed  Google Scholar 

  • Orchardson R, Cadden S (1998) Mastication. In: The scientific basis of eating. Karger Publishers, New York

    Google Scholar 

  • Orsini G, Pagella P, Putignano A, Mitsiadis TA (2018) Novel biological and technological platforms for dental clinical use. Front Physiol 9:1102

    PubMed  PubMed Central  Google Scholar 

  • Oryan A, Alidadi S, Moshiri A, Maffulli N (2014) Bone regenerative medicine: Classic options, novel strategies, and future directions. J Orthop Surg Res 9:18

    PubMed  PubMed Central  Google Scholar 

  • Osburn R (1974) Preservation of the alveolar ridge: A simplified technique for retaining teeth beneath removable appliances. J Indiana State Dent Assoc 53:8–11

    CAS  PubMed  Google Scholar 

  • Oshima M, Mizuno M, Imamura A, Ogawa M, Yasukawa M, Yamazaki H, Morita R, Ikeda E, Nakao K, Takano-Yamamoto T (2011) Functional tooth regeneration using a bioengineered tooth unit as a mature organ replacement regenerative therapy. PLoS One 6:E21531

    CAS  PubMed  PubMed Central  Google Scholar 

  • Pagni G (2016) Stem cells for periodontal regeneration. In: Dental Stem Cells: Regenerative Potential. Springer, Cham

    Google Scholar 

  • Pandey LM, Pattanayek SK (2011) Hybrid surface from self-assembled layer and its effect on protein adsorption. Appl Surf Sci 257:4731–4737

    CAS  Google Scholar 

  • Park K, Heo S, Koak J, Kim S, Lee J, Kim S, Lim Y (2007) Osseointegration of anodized titanium implants under different current voltages: A rabbit study. J Oral Rehabil 34:517–527

    CAS  PubMed  Google Scholar 

  • Peleg M, Sawatari Y, Marx RN, Santoro J, Cohen J, Bejarano P, Malinin T (2010) Use of corticocancellous allogeneic bone blocks for augmentation of alveolar bone defects. Int J Oral Max Impl 25:153–162

    Google Scholar 

  • Pietrokovski J, Massler M (1967) Alveolar ridge Resorption following tooth extraction. J Prosthet Dent 17:21–27

    CAS  PubMed  Google Scholar 

  • Pihlstrom BL, Michalowicz BS, Johnson NW (2005) Periodontal diseases. Lancet 366:1809–1820

    PubMed  Google Scholar 

  • Pilipchuk SP, Monje A, Jiao Y, Hao J, Kruger L, Flanagan CL, Hollister SJ, Giannobile WV (2016) Integration of 3d printed and micropatterned Polycaprolactone scaffolds for guidance of oriented collagenous tissue formation in vivo. Adv Healthc Mater 5:676–687

    CAS  PubMed  PubMed Central  Google Scholar 

  • Plachokova AS, Nikolidakis D, Mulder J, Jansen JA, Creugers NH (2008) Effect of platelet-rich plasma on bone regeneration in dentistry: A systematic review. Clin Oral Impl Res 19:539–545

    Google Scholar 

  • Qu T, Jing J, Jiang Y, Taylor RJ, Feng JQ, Geiger B, Liu X (2014) Magnesium-containing nanostructured hybrid scaffolds for enhanced dentin regeneration. Tissue Eng Part A 20:2422–2433

    CAS  PubMed  PubMed Central  Google Scholar 

  • Quattlebaunr JB, Mellonig JT, Hensel NF (1988) Antigenicity of freeze-dried cortical bone allograft in human periodontal osseous defects. J Periodontol 59:394–397

    Google Scholar 

  • Raphel J, Karlsson J, Galli S, Wennerberg A, Lindsay C, Haugh MG, Pajarinen J, Goodman SB, Jimbo R, Andersson M (2016) Engineered protein coatings to improve the Osseointegration of dental and Orthopaedic implants. Biomaterials 83:269–282

    CAS  PubMed  PubMed Central  Google Scholar 

  • Reynolds MA, Aichelmann-Reidy ME, Branch-Mays GL (2010) Regeneration of periodontal tissue: Bone replacement grafts. Dent Clin 54:55–71

    Google Scholar 

  • Roccuzzo M, Ramieri G, Spada MC, Bianchi SD, Berrone S (2004) Vertical alveolar ridge augmentation by means of a titanium mesh and autogenous bone grafts. Clin Oral Impl Res 15:73–81

    Google Scholar 

  • Roumanas ED (2009) The social solution – denture esthetics, phonetics, and function. J Prosthodont: Implant, Esthetic and Reconstructive Dentistry 18:112–115

    Google Scholar 

  • Russell J, Scarborough N, Chesmel K (1997) Re: Ability of commercial demineralized freeze-dried bone allograft to induce new bone formation (1996; 67: 918–26). J Periodontol 68:804–806

    CAS  PubMed  Google Scholar 

  • Sagar N, Pandey AK, Gurbani D, Khan K, Singh D, Chaudhari BP, Soni VP, Chattopadhyay N, Dhawan A, Bellare JR (2013) In-vivo efficacy of compliant 3d Nano-composite in critical-size bone defect repair: A six month preclinical study in rabbit. PLoS One 8:E77578

    CAS  PubMed  PubMed Central  Google Scholar 

  • Sakai V, Zhang Z, Dong Z, Neiva K, Machado M, Shi S, Santos C, Nör J (2010) Shed differentiate into functional Odontoblasts and endothelium. J Dent Res 89:791–796

    CAS  PubMed  Google Scholar 

  • Sartori S, Silvestri M, Forni F, Icaro Cornaglia A, Tesei P, Cattaneo V (2003) Ten-year follow-up in a maxillary sinus augmentation using Anorganic bovine bone (bio-Oss). A case report with Histomorphometric evaluation. Clin Oral Impl Res 14:369–372

    Google Scholar 

  • Schallhorn RG (1977) Present status of osseous grafting procedures. J Periodontol 48:570–576

    CAS  PubMed  Google Scholar 

  • Schei O, Waerhaug J, Lovdal A, Arno A (1959) Alveolar bone loss as related to Oral hygiene and age. J Periodontol 30:7–16

    Google Scholar 

  • Schepers E, Clercq MD, Ducheyne P, Kempeneers R (1991) Bioactive glass particulate material as a filler for bone lesions. J Oral Rehabil 18:439–452

    CAS  PubMed  Google Scholar 

  • Sculean A, Nikolidakis D, Schwarz F (2008) Regeneration of periodontal tissues: Combinations of barrier membranes and grafting materials–biological foundation and preclinical evidence: A systematic review. J Clin Periodontol 35:106–116

    CAS  PubMed  Google Scholar 

  • SekuÅ‚a M, Zuba-Surma EK (2018) Biomaterials and stem cells: Promising tools in tissue engineering and biomedical applications. Biomaterials in Regenerative Medicine. Intech

    Google Scholar 

  • Selvig KA, Sorensen RG, Wozney JM, Wikesjö UM (2002) Bone repair following recombinant human bone morphogenetic Protein-2 stimulated periodontal regeneration. J Periodontol 73:1020–1029

    CAS  PubMed  Google Scholar 

  • Seo B-M, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, Young M, Robey PG, Wang CY, Shi S (2004) Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 364:149–155

    CAS  PubMed  Google Scholar 

  • Shetty V, Han T (1991) Alloplastic materials in reconstructive periodontal surgery. Dent Clin N Am 35:521–530

    CAS  PubMed  Google Scholar 

  • Shillingburg HT, Sather DA, Wilson EL, Cain JR, Mitchell DL, Blanco LJ, Kessler JC (2012) Fundamentals of fixed prosthodontics. Quintessence Publishing Company, Hanover Park, IL

    Google Scholar 

  • Smith DE, Zarb GA (1989) Criteria for success of Osseointegrated Endosseous implants. J Prosthet Dent 62:567–572

    CAS  PubMed  Google Scholar 

  • Song JH, Kim HE, Kim HW (2007) Collagen-apatite Nanocomposite membranes for guided bone regeneration. J Biomed Mater Res B: Applied Biomaterials: An Official Journal of the Society for Biomaterials, the Japanese Society for Biomaterials, and the Australian Society for Biomaterials and the Korean Society for Biomaterials 83:248–257

    Google Scholar 

  • Sonoyama W, Liu Y, Fang D, Yamaza T, Seo B-M, Zhang C, Liu H, Gronthos S, Wang C-Y, Shi S (2006) Mesenchymal stem cell-mediated functional tooth regeneration in swine. PLoS One 1:E79

    PubMed  PubMed Central  Google Scholar 

  • Suba Z, Takács D, Gyulai-Gaál S, Kovács K (2004) Facilitation of Î’-Tricalcium phosphate-induced alveolar bone regeneration by platelet-rich plasma in beagle dogs: A histologic and Histomorphometric study. Int J Oral Max Impl 19:158–165

    Google Scholar 

  • Sumita Y, Honda MJ, Ohara T, Tsuchiya S, Sagara H, Kagami H, Ueda M (2006) Performance of collagen sponge as a 3-D scaffold for tooth-tissue engineering. Biomaterials 27:3238–3248

    CAS  PubMed  Google Scholar 

  • Sutton D, Lewis B, Patel M, Cawood J (2004) Changes in facial form relative to progressive atrophy of the edentulous jaws. Int J Oral Max Surg 33:676–682

    CAS  Google Scholar 

  • Tatakis DN, Promsudthi A, Wikesjö UM (1999) Devices for periodontal regeneration. Periodontology 2000(19):59–73

    Google Scholar 

  • Taylor TD (1998) Prosthodontic problems and limitations associated with Osseointegration. J Prosthet Dent 79:74–78

    CAS  PubMed  Google Scholar 

  • Ten Heggeler J, Slot D, Van Der Weijden G (2011) Effect of socket preservation therapies following tooth extraction in non-molar regions in humans: A systematic review. Clin Oral Impl Res 22:779–788

    Google Scholar 

  • Thesleff I, Hurmerinta K (1981) Tissue interactions in tooth development. Differentiation 18:75–88

    CAS  PubMed  Google Scholar 

  • Tomlin EM, Nelson SJ, Rossmann JA (2014) Suppl 1: Ridge preservation for implant therapy: A review of the literature. Open Dent J 8:66

    PubMed  PubMed Central  Google Scholar 

  • Tonomura A, Mizuno D, Hisada A, Kuno N, Ando Y, Sumita Y, Honda MJ, Satomura K, Sakurai H, Ueda M (2010) Differential effect of scaffold shape on dentin regeneration. Ann Biomed Eng 38:1664–1671

    PubMed  Google Scholar 

  • Allen PF, McMillan AS (2003) A review of the functional and psychosocial outcomes of Edentulousness treated with complete replacement dentures. J Can Dent Assoc 69:662

    Google Scholar 

  • Urabe M, Hosokawa R, Chiba D, Sato Y, Akagawa Y (2000) Morphogenetic behavior of Periodontium on inorganic implant materials: An experimental study of canines. J Biomed Mater Res: An Official Journal of the Society for Biomaterials, the Japanese Society for Biomaterials, and the Australian Society for Biomaterials and the Korean Society for Biomaterials 49:17–24

    CAS  Google Scholar 

  • Villar CC, Cochran DL (2010) Regeneration of periodontal tissues: Guided tissue regeneration. Dent Clin 54:73–92

    Google Scholar 

  • Vining KH, Scherba JC, Bever AM, Alexander MR, Celiz AD, Mooney DJ (2018) Synthetic light-curable polymeric materials provide a supportive niche for dental pulp stem cells. Adv Mater 30:1704486

    Google Scholar 

  • Vittorini Orgeas G, Clementini M, De Risi V, De Sanctis M (2013) Surgical techniques for alveolar socket preservation: A systematic review. Int J Oral Max Impl 28:1049–1061

    Google Scholar 

  • Vroman I, Tighzert L (2009) Biodegradable Polymers. Dent Mater 2:307–344

    CAS  Google Scholar 

  • Wang W, Dang M, Zhang Z, Hu J, Eyster TW, Ni L, Ma PX (2016) Dentin regeneration by stem cells of apical papilla on injectable Nanofibrous microspheres and stimulated by controlled bmp-2 release. Acta Biomater 36:63–72

    CAS  PubMed  PubMed Central  Google Scholar 

  • Warrer K, Karring T, Gotfredsen K (1993) Periodontal ligament formation around different types of dental titanium implants. I. the self-tapping screw type implant system. J Periodontol 64:29–34

    CAS  PubMed  Google Scholar 

  • Wei F, Song T, Ding G, Xu J, Liu Y, Liu D, Fan Z, Zhang C, Shi S, Wang S (2013a) Functional tooth restoration by allogeneic Mesenchymal stem cell-based bio-root regeneration in swine. Stem Cells Dev 22:1752–1762

    CAS  PubMed  PubMed Central  Google Scholar 

  • Wei X, Yang X, Han Z-P, Qu F-F, Shao L, Shi Y-F (2013b) Mesenchymal stem cells: A new trend for cell therapy. Acta Pharmacol Sin 34:747

    CAS  PubMed  PubMed Central  Google Scholar 

  • Weigel T, Schinkel G, Lendlein A (2006) Design and preparation of polymeric scaffolds for tissue engineering. Expert Rev Med Devices 3:835–851

    CAS  PubMed  Google Scholar 

  • Wiens JP (1990) Acquired maxillofacial defects from motor vehicle accidents: Atatistics and Prosthodontic considerations. J Prosthet Dent 63:172–181

    CAS  PubMed  Google Scholar 

  • Wikesjö UM, Guglielmoni P, Promsudthi A, Cho KS, Trombelli L, Selvig KA, Jin L, Wozney JM (1999) Periodontal repair in dogs: Effect of Rhbmp-2 concentration on regeneration of alveolar bone and periodontal attachment. J Clin Periodontol 26:392–400

    PubMed  Google Scholar 

  • Willis RD, Dicosimo CJ (1979) The absence of proprioceptive nerve endings in the human periodontal ligament: The role of periodontal mechanoreceptors in the reflex control of mastication. Oral Surg Oral Med Oral Pathol Oral Radiol 48:108–115

    CAS  Google Scholar 

  • Wu Y, Xia H, Zhang B, Zhao Y, Wang Y (2018) Assessment of Polyglycolic acid scaffolds for periodontal ligament regeneration. Biotechnol Biotech Eq 32:701–706

    CAS  Google Scholar 

  • Xiao Y, Qian H, Young WG, Bartold PM (2003) Tissue engineering for bone regeneration using differentiated alveolar bone cells in collagen scaffolds. Tissue Eng 9:1167–1177

    CAS  PubMed  Google Scholar 

  • Yamada Y, Ueda M, Naiki T, Takahashi M, Hata K-I, Nagasaka T (2004) Autogenous injectable bone for regeneration with Mesenchymal stem cells and platelet-rich plasma: Tissue-engineered bone regeneration. Tissue Eng 10:955–964

    CAS  PubMed  Google Scholar 

  • Yang X, Yang F, Walboomers XF, Bian Z, Fan M, Jansen JA (2010) The performance of dental pulp stem cells on Nanofibrous Pcl/gelatin/Nha scaffolds. J Biomed Mater Res A: An Official Journal of the Society for Biomaterials, the Japanese Society for Biomaterials, and the Australian Society for Biomaterials and the Korean Society for Biomaterials 93:247–257

    Google Scholar 

  • Yang F, Zhao S-F, Zhang F, He F-M, Yang G-L (2011a) Simvastatin-loaded porous implant surfaces stimulate Preosteoblasts differentiation: An in vitro study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 111:551–556

    PubMed  Google Scholar 

  • Yang X, Han G, Pang X, Fan M (2011b) Chitosan/collagen scaffold containing bone morphogenetic protein-7 DNA supports dental pulp stem cell differentiation in vitro and in vivo. J Biomed Mater Res A. https://doi.org/10.1002/jbm.a.34064

  • Yang B, Chen G, Li J, Zou Q, Xie D, Chen Y, Wang H, Zheng X, Long J, Tang W (2012) Tooth root regeneration using dental follicle cell sheets in combination with a dentin matrix-based scaffold. Biomaterials 33:2449–2461

    CAS  PubMed  Google Scholar 

  • Yar M, Farooq A, Shahzadi L, Khan AS, Mahmood N, Rauf A, Chaudhry AA, Ur Rehman I (2016) Novel meloxicam releasing electrospun polymer/ceramic reinforced biodegradable membranes for periodontal regeneration applications. Mater Sci Eng C 64:148–156

    CAS  Google Scholar 

  • Yen AH-H, Sharpe PT (2008) Stem cells and tooth tissue engineering. Cell Tissue Res 331:359–372

    CAS  PubMed  Google Scholar 

  • Yoshida M, Kikutani T, Okada G, Kawamura T, Kimura M, Akagawa Y (2009) The effect of tooth loss on body balance control among community-dwelling elderly persons. Int J Prosthodont 22:136–139

    PubMed  Google Scholar 

  • Young CS, Terada S, Vacanti JP, Honda M, Bartlett JD, Yelick PC (2002) Tissue engineering of complex tooth structures on biodegradable polymer scaffolds. J Dent Res 81:695–700

    CAS  PubMed  Google Scholar 

  • Young CS, Abukawa H, Asrican R, Ravens M, Troulis MJ, Kaban LB, Vacanti JP, Yelick PC (2005) Tissue-engineered hybrid tooth and bone. Tissue Eng 11:1599–1610

    CAS  PubMed  Google Scholar 

  • Yuan Z, Nie H, Wang S, Lee CH, Li A, Fu SY, Zhou H, Chen L, Mao JJ (2011) Biomaterial selection for tooth regeneration. Tissue Eng Part B Rev 17:373–388

    CAS  PubMed  PubMed Central  Google Scholar 

  • Zara JN, Siu RK, Zhang X, Shen J, Ngo R, Lee M, Li W, Chiang M, Chung J, Kwak J (2011) High doses of bone morphogenetic protein 2 induce structurally abnormal bone and inflammation in vivo. Tissue Eng Part A 17:1389–1399

    CAS  PubMed  PubMed Central  Google Scholar 

  • Zeng X-T, Luo W, Huang W, Wang Q, Guo Y, Leng W-D (2013) Tooth loss and head and neck cancer: A meta-analysis of observational studies. PLoS One 8:E79074

    PubMed  PubMed Central  Google Scholar 

  • Zerbo IR, Bronckers AL, De Lange GL, Burger EH, Van Beek GJ (2001) Histology of human alveolar bone regeneration with a porous Tricalcium phosphate: A report of two cases. Clin Oral Impl Res 12:379–384

    CAS  Google Scholar 

  • Zhang Y, Song J, Shi B, Wang Y, Chen X, Huang C, Yang X, Xu D, Cheng X, Chen X (2007) Combination of scaffold and adenovirus vectors expressing bone morphogenetic Protein-7 for alveolar bone regeneration at dental implant defects. Biomaterials 28:4635–4642

    CAS  PubMed  Google Scholar 

  • Zhao G, Zinger O, Schwartz Z, Wieland M, Landolt D, Boyan BD (2006) Osteoblast-like cells are sensitive to submicron-scale surface structure. Clin Oral Impl Res 17:258–264

    Google Scholar 

  • Zheng Y, Wang X, Wang Y, Liu X, Zhang C, Hou B, Wang S (2012) Dentin regeneration using deciduous pulp stem/progenitor cells. J Dent Res 91:676–682

    CAS  PubMed  Google Scholar 

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  1. Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India

    Siddhartha Das & Vivek P. Soni

  2. Department of Chemical Engineering, Indian Institute of Technology Bombay, Mumbai, India

    Siddhartha Das & Jayesh R. Bellare

  3. Wadhwani Research Centre for Bioengineering (WRCB), Indian Institute of Technology Bombay, Mumbai, India

    Jayesh R. Bellare

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  1. Laboratory of Bio-Physio Sensors and Nano-bioengineering, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India

    Pranjal Chandra

  2. Bio-interface and Environmental Engineering Lab, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India

    Lalit M. Pandey

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Das, S., Soni, V.P., Bellare, J.R. (2020). Tissue Engineering Strategies for Tooth and Dento-alveolar Region with Engineered Biomaterial and Stem Cells. In: Chandra, P., Pandey, L. (eds) Biointerface Engineering: Prospects in Medical Diagnostics and Drug Delivery . Springer, Singapore. https://doi.org/10.1007/978-981-15-4790-4_2

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