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Microbiome in Asthma

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Microbiome in Inflammatory Lung Diseases

Abstract

Asthma is a prevalent persistent pulmonary illness that affects people all over the world. It affects people of all ages, although it is more common in children. Individual predisposition, virus infections, allergens contact, cigarette smoke exposure, and exposure to air pollution may all have a role in the onset and aggravation of asthma. Many studies have shown that the microbiome has a role in the regulation of immune function and the development of atopy and asthma. The lack of early life experience to the varied ambient microbiome required for colonisation of the pulmonary tracts and/or gastrointestinal appears to be the foundation of many clinical disorders. The establishment of a balanced, tolerogenic immune response requires symbiotic microorganisms. The discovery of symbiotic microorganisms in the pulmonary tracts and gastroenterological might be a game-changing and crucial development. The importance of microbiome in a healthy immune reaction is widely recognised, and gut dysbacteriosis has been linked to severe inflammatory respiratory diseases, notably asthma. To further understand the role of the microbiota in inflammatory process and its influence on important asthma risk variables including cigarette smoke and host genetic features, more study is needed.

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References

  1. Abdel-Aziz MI, Vijverberg SJH, Neerincx AH, Kraneveld AD (2019) Maitland-van der Zee AH. The crosstalk between microbiome and asthma: Exploring associations and challenges. Clin Exp Allergy 49(8):1067–1086

    Article  PubMed  PubMed Central  Google Scholar 

  2. Adami AJ, Bracken SJ (2016) Breathing better through bugs: asthma and the microbiome. Yale J Biol Med 89(3):309–324

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Adelman MW, Woodworth MH, Langelier C, Busch LM, Kempker JA, Kraft CS et al (2020) The gut microbiome’s role in the development, maintenance, and outcomes of sepsis. Crit Care 24(1):278

    Article  PubMed  PubMed Central  Google Scholar 

  4. Banskar S, Detzner AA, Juarez-Rodriguez MD, Hozo I, Gupta D, Dziarski R (2019) The Pglyrp1-regulated microbiome enhances experimental allergic asthma. J Immunol. 203(12):3113–3125

    Article  CAS  PubMed  Google Scholar 

  5. Barcik W, Boutin RCT, Sokolowska M, Finlay BB (2020) The role of lung and gut microbiota in the pathology of asthma. Immunity 52(2):241–255

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Barko PC, McMichael MA, Swanson KS, Williams DA (2018) The gastrointestinal microbiome: a review. J Vet Intern Med 32(1):9–25

    Article  CAS  PubMed  Google Scholar 

  7. Barnig C, Martin C (2018) [Asthma and the microbiome]. Rev Mal Respir 35(2):103–115

    Google Scholar 

  8. Bonamichi-Santos R, Aun MV, Agondi RC, Kalil J, Giavina-Bianchi P (2015) Microbiome and asthma: what have experimental models already taught us? J Immunol Res 2015:614758

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Borbet TC, Zhang X, Müller A, Blaser MJ (2019) The role of the changing human microbiome in the asthma pandemic. J Allergy Clin Immunol 144(6):1457–1466

    Article  PubMed  PubMed Central  Google Scholar 

  10. Budden KF, Shukla SD, Rehman SF, Bowerman KL, Keely S, Hugenholtz P et al (2019) Functional effects of the microbiota in chronic respiratory disease. Lancet Respir Med 7(10):907–920

    Article  PubMed  Google Scholar 

  11. Carr TF, Alkatib R, Kraft M (2019) Microbiome in mechanisms of asthma. Clin Chest Med 40(1):87–96

    Article  PubMed  Google Scholar 

  12. Chen R, Wang L, Koch T, Curtis V, Yin-DeClue H, Handley SA et al (2020) Sex effects in the association between airway microbiome and asthma. Ann Allergy Asthma Immunol. 125(6):652–7.e3

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Cho Y, Shore SA (2016) Obesity, asthma, and the microbiome. Physiology (Bethesda). 31(2):108–116

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Das B, Nair GB (2019) Homeostasis and dysbiosis of the gut microbiome in health and disease. J Biosci. 44(5):117

    Article  PubMed  Google Scholar 

  15. Depner M, Taft DH, Kirjavainen PV, Kalanetra KM, Karvonen AM, Peschel S et al (2020) Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma. Nat Med 26(11):1766–1775

    Article  CAS  PubMed  Google Scholar 

  16. Di Cicco M, Pistello M, Jacinto T, Ragazzo V, Piras M, Freer G et al (2018) Does lung microbiome play a causal or casual role in asthma? Pediatr Pulmonol 53(10):1340–1345

    Article  PubMed  Google Scholar 

  17. Dick S, Turner S (2020) The airway microbiome and childhood asthma - what is the link? Acta Med Acad 49(2):156–163

    Article  PubMed  Google Scholar 

  18. Dickson RP (2016) The microbiome and critical illness. Lancet Respir Med 4(1):59–72

    Article  PubMed  Google Scholar 

  19. Durack J, Lynch SV, Nariya S, Bhakta NR, Beigelman A, Castro M et al (2017) Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment. J Allergy Clin Immunol 140(1):63–75

    Article  CAS  PubMed  Google Scholar 

  20. Ege MJ (2017) The hygiene hypothesis in the age of the microbiome. Ann Am Thorac Soc. 14(Supplement_5):S348–Ss53

    Article  PubMed  Google Scholar 

  21. Fazlollahi M, Lee TD, Andrade J, Oguntuyo K, Chun Y, Grishina G et al (2018) The nasal microbiome in asthma. J Allergy Clin Immunol. 142(3):834–43.e2

    Article  PubMed  PubMed Central  Google Scholar 

  22. Frati F, Salvatori C, Incorvaia C, Bellucci A, Di Cara G, Marcucci F et al (2018) The role of the microbiome in asthma: the gut−lung axis. Int J Mol Sci. 20(1):123

    Article  PubMed Central  Google Scholar 

  23. Fujimura KE, Lynch SV (2015) Microbiota in allergy and asthma and the emerging relationship with the gut microbiome. Cell Host Microbe 17(5):592–602

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. García-Rivero JL (2020) The microbiome and asthma. Arch Bronconeumol 56(1):1–2

    Article  PubMed  Google Scholar 

  25. Guilleminault L, Williams EJ, Scott HA, Berthon BS, Jensen M, Wood LG (2017) Diet and asthma: is it time to adapt our message? Nutrients. 9(11):1227

    Article  PubMed Central  Google Scholar 

  26. Huang C, Shi G (2019) Smoking and microbiome in oral, airway, gut and some systemic diseases. J Transl Med 17(1):225

    Article  PubMed  PubMed Central  Google Scholar 

  27. Huang YJ (2015) The respiratory microbiome and innate immunity in asthma. Curr Opin Pulm Med 21(1):27–32

    Article  PubMed  PubMed Central  Google Scholar 

  28. Huang YJ, Boushey HA (2015) The microbiome in asthma. J Allergy Clin Immunol 135(1):25–30

    Article  PubMed  PubMed Central  Google Scholar 

  29. Huang YJ, Marsland BJ, Bunyavanich S, O’Mahony L, Leung DY, Muraro A et al (2017) The microbiome in allergic disease: Current understanding and future opportunities-2017 PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology. J Allergy Clin Immunol 139(4):1099–1110

    Article  PubMed  PubMed Central  Google Scholar 

  30. Hufnagl K, Pali-Schöll I, Roth-Walter F, Jensen-Jarolim E (2020) Dysbiosis of the gut and lung microbiome has a role in asthma. Semin Immunopathol 42(1):75–93

    Article  PubMed  PubMed Central  Google Scholar 

  31. Jartti T, Bønnelykke K, Elenius V, Feleszko W (2020) Role of viruses in asthma. Semin Immunopathol 42(1):61–74

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Jartti T, Gern JE (2017) Role of viral infections in the development and exacerbation of asthma in children. J Allergy Clin Immunol 140(4):895–906

    Article  PubMed  PubMed Central  Google Scholar 

  33. Kozik AJ, Huang YJ (2019) The microbiome in asthma: Role in pathogenesis, phenotype, and response to treatment. Ann Allergy Asthma Immunol 122(3):270–275

    Article  PubMed  Google Scholar 

  34. Langan SM, Irvine AD, Weidinger S (2020) Atopic dermatitis. Lancet. 396(10247):345–360

    Article  CAS  PubMed  Google Scholar 

  35. Mammen MJ, Scannapieco FA, Sethi S (2020) Oral-lung microbiome interactions in lung diseases. Periodontology 2000. 83(1):234–241

    Article  PubMed  Google Scholar 

  36. McAleer JP, Kolls JK (2018) Contributions of the intestinal microbiome in lung immunity. Eur J Immunol 48(1):39–49

    Article  CAS  PubMed  Google Scholar 

  37. McKenzie C, Tan J, Macia L, Mackay CR (2017) The nutrition-gut microbiome-physiology axis and allergic diseases. Immunol Rev 278(1):277–295

    Article  CAS  PubMed  Google Scholar 

  38. Michalovich D, Rodriguez-Perez N, Smolinska S, Pirozynski M, Mayhew D, Uddin S et al (2019) Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients. Nat Commun 10(1):5711

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Milani C, Duranti S, Bottacini F, Casey E, Turroni F, Mahony J et al (2017) The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota. Microbiol Mol Biol Rev. 81(4):e00036–e00017

    Article  PubMed  PubMed Central  Google Scholar 

  40. Milliken S, Allen RM, Lamont RF (2019) The role of antimicrobial treatment during pregnancy on the neonatal gut microbiome and the development of atopy, asthma, allergy and obesity in childhood. Expert Opin Drug Saf 18(3):173–185

    Article  CAS  PubMed  Google Scholar 

  41. Moffatt MF, Cookson WO (2017) The lung microbiome in health and disease. Clin Med (Lond). 17(6):525–529

    Article  PubMed  PubMed Central  Google Scholar 

  42. Mohan A, Grace J, Wang BR, Lugogo N (2019) The effects of obesity in asthma. Curr Allergy Asthma Rep 19(10):49

    Article  PubMed  Google Scholar 

  43. Moraes TJ, Sears MR, Subbarao P (2018) Epidemiology of asthma and influence of ethnicity. Semin Respir Crit Care Med 39(1):3–11

    Article  PubMed  Google Scholar 

  44. Noval Rivas M, Crother TR, Arditi M (2016) The microbiome in asthma. Curr Opin Pediatr 28(6):764–771

    Article  CAS  PubMed  Google Scholar 

  45. Ozturk AB, Turturice BA, Perkins DL, Finn PW (2017) The potential for emerging microbiome-mediated therapeutics in asthma. Curr Allergy Asthma Rep 17(9):62

    Article  PubMed  Google Scholar 

  46. Perdijk O, Marsland BJ (2019) The microbiome: toward preventing allergies and asthma by nutritional intervention. Curr Opin Immunol 60:10–18

    Article  CAS  PubMed  Google Scholar 

  47. Peroni DG, Nuzzi G, Trambusti I, Di Cicco ME, Comberiati P (2020) Microbiome composition and its impact on the development of allergic diseases. Front Immunol 11:700

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Peters U, Dixon AE, Forno E (2018) Obesity and asthma. J Allergy Clin Immunol 141(4):1169–1179

    Article  PubMed  PubMed Central  Google Scholar 

  49. Pettersen VK, Arrieta MC (2020) Host-microbiome intestinal interactions during early life: considerations for atopy and asthma development. Curr Opin Allergy Clin Immunol 20(2):138–148

    Article  PubMed  Google Scholar 

  50. Pisi G, Fainardi V, Aiello M, Bertorelli G, Crisafulli E, Chetta A (2017) The role of the microbiome in childhood asthma. Immunotherapy 9(15):1295–1304

    Article  CAS  PubMed  Google Scholar 

  51. Prince BT, Mandel MJ, Nadeau K, Singh AM (2015) Gut microbiome and the development of food allergy and allergic disease. Pediatr Clin N Am 62(6):1479–1492

    Article  Google Scholar 

  52. Rick EM, Woolnough KF, Seear PJ, Fairs A, Satchwell J, Richardson M et al (2020) The airway fungal microbiome in asthma. Clin Exp Allergy 50(12):1325–1341

    Article  CAS  PubMed  Google Scholar 

  53. Scherzer R, Grayson MH (2018) Heterogeneity and the origins of asthma. Ann Allergy Asthma Immunol 121(4):400–405

    Article  PubMed  PubMed Central  Google Scholar 

  54. Shore SA, Cho Y (2016) Obesity and asthma: microbiome-metabolome interactions. Am J Respir Cell Mol Biol 54(5):609–617

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Shukla SD, Shastri MD, Chong WC, Dua K, Budden KF, Mahmood MQ et al (2019) Microbiome-focused asthma management strategies. Curr Opin Pharmacol 46:143–149

    Article  CAS  PubMed  Google Scholar 

  56. Sozańska B (2019) Microbiome in the primary prevention of allergic diseases and bronchial asthma. Allergol Immunopathol 47(1):79–84

    Article  Google Scholar 

  57. Stiemsma LT, Michels KB (2018) The role of the microbiome in the developmental origins of health and disease. Pediatrics. 141(4):e20172437

    Article  PubMed  Google Scholar 

  58. Stokholm J, Blaser MJ, Thorsen J, Rasmussen MA, Waage J, Vinding RK et al (2018) Maturation of the gut microbiome and risk of asthma in childhood. Nat Commun 9(1):141

    Article  PubMed  PubMed Central  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Al-Jouf, Saudi Arabia

    Khalid Saad Alharbi

  2. Department of Pharmacology and Toxicology, Unaizah College of Pharmacy, Qassim University, Unaizah City, Qassim, Saudi Arabia

    Sattam Khulaif Alenezi & Sulaiman Mohammed Alnasser

Authors
  1. Khalid Saad Alharbi
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  2. Sattam Khulaif Alenezi
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  3. Sulaiman Mohammed Alnasser
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Corresponding author

Correspondence to Khalid Saad Alharbi .

Editor information

Editors and Affiliations

  1. School of Pharmacy, Suresh Gyan Vihar University, Jaipur, India

    Gaurav Gupta

  2. School of Life Sciences, University of Technology Sydney, Sydney, NSW, Australia

    Brian G. Oliver

  3. Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW, Australia

    Kamal Dua

  4. School of Pharmacy, Suresh Gyan Vihar University, Jaipur, India

    Alisha Singh

  5. R&D Science and Emerging Technologies, Aerogen Limited, Dangan, Ireland

    Ronan MacLoughlin

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Alharbi, K.S., Alenezi, S.K., Alnasser, S.M. (2022). Microbiome in Asthma. In: Gupta, G., Oliver, B.G., Dua, K., Singh, A., MacLoughlin, R. (eds) Microbiome in Inflammatory Lung Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-16-8957-4_5

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