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Wilms’ Tumor in Resource-Challenged Nations

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Wilms’ Tumor

Abstract

Ignorance, poverty, cultural issues, late presentations, concomitant malnutrition and other infections and infestations, limited resources, therapy abandonment, and lack of post-therapy surveillance are the different reasons that lead to poor outcomes for pediatric Wilms’ tumors in low- and middle-income countries. These factors mandate prioritization in resource utilization so to save and cure those who have better prognosis and use of adapted regimens that could give comparable outcomes in such settings. The learning objectives of this chapter include knowledge of the challenges to Wilms’ tumor care in resource challenged nations and that of the cost-effective “adapted regimens” used there that may be different from the regimens used in high-income countries.

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References

  1. Hadley LG, Rouma BS, Saad-Eldin Y. Challenge of pediatric oncology in Africa. Semin Pediatr Surg. 2012;21:136–41. https://doi.org/10.1053/j.sempedsurg.2012.01.

    Article  PubMed  Google Scholar 

  2. Cunningham ME, Klug TD, Nuchtern JG, Chintagumpala MM, Venkatramani R, Lubega J, et al. Global disparities in Wilms tumor. J Surg Res. 2020;247:34–51. https://doi.org/10.1016/j.jss.2019.10.044.

    Article  PubMed  Google Scholar 

  3. Magrath I, Steliarova-Foucher E, Epelman S, Ribeiro RC, Harif M, Li CK, et al. Paediatric cancer in low-income and middle-income countries. Lancet Oncol. 2013;14:e104–16. https://doi.org/10.1016/S1470-2045(13)70008-1.

    Article  PubMed  Google Scholar 

  4. Hadley GP, Govender D, Landers G. Wilms tumour with unfavourable histology: implications for clinicians in the third world. Med Pediatr Oncol. 2001;36:652–3. https://doi.org/10.1002/mpo.1145.

    Article  CAS  PubMed  Google Scholar 

  5. Howard SC, Davidson A, Luna-Fineman S, Israels T, Chantada G, Lam CG, et al. A framework to develop adapted treatment regimens to manage pediatric cancer in low- and middle-income countries: the pediatric oncology in developing countries (PODC) Committee of the International Pediatric Oncology Society (SIOP). Pediatr Blood Cancer. 2017;64(Suppl 5):26879. https://doi.org/10.1002/pbc.26879.

    Article  Google Scholar 

  6. Arora RS, Challinor JM, Howard SC, Israels T. Improving care for children with cancer in low- and middle-income countries—a SIOP PODC initiative. Pediatr Blood Cancer. 63:387–91. https://doi.org/10.1002/pbc.25810.

  7. Carter NH, Avery AH, Libes J, Lovvorn HN 3rd, Hansen EN. Pediatric solid tumors in resource-constrained settings: a review of available evidence on management, outcomes, and barriers to care. Children (Basel). 2018;5:143. https://doi.org/10.3390/children5110143.

    Article  Google Scholar 

  8. D'Angio GJ, Breslow N, Beckwith JB, Evans A, Baum H, deLorimier A, et al. Treatment of Wilms’ tumor. Results of the third National Wilms’ tumor study. Cancer. 1989;64:349–60. https://doi.org/10.1002/1097-0142(19890715)64:2<349::aid-cncr2820640202>3.0.co;2-q.

    Article  CAS  PubMed  Google Scholar 

  9. Pritchard J, Imeson J, Barnes J, Cotterill S, Gough D, Marsden HB, et al. Results of the United Kingdom Children’s cancer study group first Wilms’ tumor study. J Clin Oncol. 1995;13:124–33. https://doi.org/10.1200/JCO.1995.13.1.124.

  10. Aronson DC, Maharaj A, Sheik-Gafoor MH, Hadley GP. The results of treatment of children with metastatic Wilms tumours (WT) in an African setting: do liver metastases have a negative impact on survival? Pediatr Blood Cancer. 2012;59:391–4. https://doi.org/10.1002/pbc.24080.

    Article  PubMed  Google Scholar 

  11. Rabeh W, Akel S, Eid T, Muwakkit S, Abboud M, El Solh H, et al. Wilms tumor: successes and challenges in management outside of cooperative clinical trials. Hematol Oncol Stem Cell Ther. 2016;9:20–5. https://doi.org/10.1016/j.hemonc.2015.12.006.

    Article  PubMed  Google Scholar 

  12. Lovvorn HN 3rd, Pierce J, Libes J, Li B, Wei Q, Correa H, et al.; Kenyan Wilms Tumor Consortium. Genetic and chromosomal alterations in Kenyan Wilms tumor. Genes Chromosomes Cancer. 2015;54:702–15. https://doi.org/10.1002/gcc.22281.

  13. Paintsil V, David H, Kambugu J, Renner L, Kouya F, Eden T, et al. The collaborative Wilms tumour Africa project; baseline evaluation of Wilms tumour treatment and outcome in eight institutes in sub-Saharan Africa. Eur J Cancer. 2015;51:84–91. https://doi.org/10.1016/j.ejca.2014.10.030.

    Article  PubMed  Google Scholar 

  14. Sen S, Kadamba P, Al-AbdulAaly M, Mammen KE, Ahmed S. Results of Wilms’ tumour management in two tertiary-care hospitals in Asia. Pediatr Surg Int. 1998;13:42–4. https://doi.org/10.1007/s003830050240.

    Article  CAS  PubMed  Google Scholar 

  15. Friedrich P, Lam CG, Kaur G, Itriago E, Ribeiro RC, Arora RS. Determinants of treatment abandonment in childhood cancer: results from a global survey. PLoS One. 2016;11:e0163090. https://doi.org/10.1371/journal.pone.0163090.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Hadley GP, Mars M, Ramdial PK. Bilateral Wilms’ tumour in a developing country: a descriptive study. Pediatr Surg Int. 2013;29:419–23. https://doi.org/10.1007/s00383-013-3287-7.

    Article  CAS  PubMed  Google Scholar 

  17. Moreira C, Nachef MN, Ziamati S, Ladjaj Y, Barsaoui S, Mallon B, et al. Treatment of nephroblastoma in Africa: results of the first French African pediatric oncology group (GFAOP) study. Pediatr Blood Cancer. 2012;58:37–42. https://doi.org/10.1002/pbc.23284.

    Article  PubMed  Google Scholar 

  18. Israels T, Moreira C, Scanlan T, Molyneux L, Kampondeni S, Hesseling P, et al. SIOP PODC: clinical guidelines for the management of children with Wilms tumour in a low income setting. Pediatr Blood Cancer. 2013;60:5–11. https://doi.org/10.1002/pbc.24321.

    Article  PubMed  Google Scholar 

  19. Lusu T, Buhlungu N, Grant H. The attitudes of parents to traditional medicine and the surgeon. S Afr Med J. 2001;91:270–1.

    CAS  PubMed  Google Scholar 

  20. Mostert S, Lam CG, Njuguna F, Patenaude AF, Kulkarni K, Salaverria C, SIOP PODC Global Taskforce on Hospital Detention Practices. Hospital detention practices: statement of a global taskforce. Lancet. 2015;386(9994):649. https://doi.org/10.1016/S0140-6736(15)61495-7.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Libes JM, Seeley EH, Li M, Axt JR, Pierce J, Correa H, et al; Kenyan Wilms Tumor Consortium. Race disparities in peptide profiles of north American and Kenyan Wilms tumor specimens. J Am Coll Surg. 2014;218:707–20. https://doi.org/10.1016/j.jamcollsurg.2013.12.044.

  22. Murphy AJ, Axt JR, de Caestecker C, Pierce J, Correa H, Seeley EH, et al. Molecular characterization of Wilms’ tumor from a resource-constrained region of sub-Saharan Africa. Int J Cancer. 2012;131:E983–94. https://doi.org/10.1002/ijc.27544.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Prasad M, Vora T, Agarwala S, Laskar S, Arora B, Bansal D, et al. Management of Wilms tumor: ICMR consensus document. Indian J Pediatr. 2017;84:437–45. https://doi.org/10.1007/s12098-017-2305-5.

    Article  PubMed  Google Scholar 

  24. de Kraker J, Graf N, Pritchard-Jones K, Pein F. Nephroblastoma clinical trial and study SIOP 2001, protocol. SIOP RTSG. 2001. https://www.skion.nl/workspace/uploads/Protocol-SIOP-2001.pdf. Accessed 25 May 2020.

  25. Wani SQ, Khan T, Wani SY, Lone MM, Afroz F. Wilm’s tumor-collaborative approach is needed to prevent tumor upstaging and radiotherapy delays: a single institutional study. Indian J Med Paediatr Oncol. 2019;40:409–12.

    Article  Google Scholar 

  26. Kumar A, Bakhshi S, Agarwala S. Is pre-operative chemotherapy desirable in all patients of Wilms’ tumor? Indian J Pediatr. 2017;84:709–14. https://doi.org/10.1007/s12098-017-2410-5.

    Article  PubMed  Google Scholar 

  27. Tran HD, Hoang BX. Treatment of nephroblastoma in developing countries—experience from a single center in Vietnam with NWTS 5 and SIOP 2001 protocols. Int J Cancer Clin Res. 2019;6:113. https://doi.org/10.23937/2378-3419/1410113.

    Article  CAS  Google Scholar 

  28. Dome JS, Mullen EA, Argani P. Pediatric renal tumors. In: Orkin SH, editor. Nathan and Oski’s hematology and oncology of infancy and childhood, chapter 5. 8th ed. Philadelphia: Saunders Elsevier; 2015. p. 1714–46.

    Google Scholar 

  29. Sarin YK, Sinha S. Non-Wilms malignant renal neoplasms. Proceedings of International Society of Paediatric Oncology SIOP XXXXII congress, 2010, October 21-24; Boston. Pediatr Blood Cancer. 2010;55:775–1014.

    Article  Google Scholar 

  30. Pan C, Cai JY, Xu M, Ye QD, Zhou M, Yin MZ, et al. Renal tumor in developing countries: 142 cases from a single institution at Shanghai, China. World J Pediatr. 2015;11:326–30. https://doi.org/10.1007/s12519-015-0041-3.

    Article  PubMed  Google Scholar 

  31. Oue T, Fukuzawa M, Okita H, Mugishima H, Horie H, Hata J, et al.; Japan Wilms Tumor Study (JWiTS) Group. Outcome of pediatric renal tumor treated using the Japan Wilms tumor Study-1 (JWiTS-1) protocol: a report from the JWiTS group. Pediatr Surg Int. 2009;25:923–9. https://doi.org/10.1007/s00383-009-2449-0.

  32. Miniati D, Gay AN, Parks KV, Naik-Mathuria BJ, Hicks J, Nuchtern JG, et al. Imaging accuracy and incidence of Wilms’ and non-Wilms’ renal tumors in children. J Pediatr Surg. 2008;43:1301–7. https://doi.org/10.1016/j.jpedsurg.2008.02.077.

    Article  PubMed  Google Scholar 

  33. Smets AM, de Kraker J. Malignant tumours of the kidney: imaging strategy. Pediatr Radiol. 2010;40:1010–8. https://doi.org/10.1007/s00247-010-1584-z.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Vujanić GM, Sandstedt B, Kelsey A, Sebire NJ. Central pathology review in multicenter trials and studies: lessons from the nephroblastoma trials. Cancer. 2009;115:1977–83. https://doi.org/10.1002/cncr.24214.

    Article  PubMed  Google Scholar 

  35. Hadley GP. Can surgeons fill the void in the management of children with solid tumours in not-developing countries? Pediatr Blood Cancer. 2010;55:16–7. https://doi.org/10.1002/pbc.22512.

    Article  CAS  PubMed  Google Scholar 

  36. Israels T, Chagaluka G, Pidini D, Caron H, de Kraker J, Kamiza S, et al. The efficacy and toxicity of SIOP preoperative chemotherapy in Malawian children with a Wilms tumour. Pediatr Blood Cancer. 2012;59:636–41. https://doi.org/10.1002/pbc.24088.

    Article  PubMed  Google Scholar 

  37. Israëls T, Borgstein E, Jamali M, de Kraker J, Caron HN, Molyneux EM. Acute malnutrition is common in Malawian patients with a Wilms tumour: a role for peanut butter. Pediatr Blood Cancer. 2009;53:1221–6. https://doi.org/10.1002/pbc.22158.

    Article  PubMed  Google Scholar 

  38. Yao AJ, Moreira C, Traoré F, Kaboret S, Pondy A, Rakotomahefa Narison ML, et al. Treatment of Wilms tumor in sub-Saharan Africa: results of the second French African pediatric oncology group study. J Glob Oncol. 2019;5:1–8. https://doi.org/10.1200/JGO.18.00204.

    Article  PubMed  Google Scholar 

  39. Weeks DA, Beckwith JB, Luckey DW. Relapse-associated variables in stage I favorable histology Wilms’ tumor. A report of the National Wilms’ tumor study. Cancer. 1987;60:1204–12. https://doi.org/10.1002/1097-0142(19870915)60:6<1204::aid-cncr2820600608>3.0.co;2-w.

    Article  CAS  PubMed  Google Scholar 

  40. Joko-Fru WY, Parkin DM, Borok M, Chokunonga E, Korir A, Nambooze S, Wabinga H, Liu B, Stefan C. Survival from childhood cancers in eastern Africa: a population-based registry study. Int J Cancer. 2018;143:2409–15. https://doi.org/10.1002/ijc.31723.

    Article  CAS  PubMed  Google Scholar 

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Sarin, Y.K. (2022). Wilms’ Tumor in Resource-Challenged Nations. In: Sarin, Y.K. (eds) Wilms’ Tumor. Springer, Singapore. https://doi.org/10.1007/978-981-19-3428-5_22

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  • DOI: https://doi.org/10.1007/978-981-19-3428-5_22

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