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Genetics and Epigenetics in Cardiac Psychology

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Handbook of Psychocardiology

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Abstract

Precisely how regulated patterns of gene expression under the control of diverse signaling pathways underlie the homeostatic control of neuroanatomical aspects of cardiac function remains unclear. The autonomic nervous system is distinguished by the sympathetic and parasympathetic nervous systems that are under the direct control of transcription factors that function as either activators or repressors of gene expression. While several regulatory determinants are known to coordinate the actions of activators and repressors, how these factors serve to maintain genes implicated in the neurocardiac axis is the subject of review. The discovery of regulatory complexes that serve as a functional linkage between DNA-bound transcription factors and altered chromatin structures indicates that posttranslational modifications of core histones connect aspects of neurocardiac gene function. The complexity of these regulators to alter noradrenaline transporter (NET) gene function is explored here. Recent evidence of chromatin-modifying enzymes regulating NET expression might apply to genes implicated in neurocardiology.

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Authors and Affiliations

  1. Laboratory for Vascular Translational Science, Inserm UMR-S1148, Paris, France

    Richard Bayles

  2. Epigenetics in Human Health and Disease Laboratory, Epigenomics Profiling Facility, The Alfred Medical Research and Education Precinct, Baker IDI Heart and Diabetes Institute, Fifth Floor, 75 Commercial Road, Melbourne, VIC, 3004, Australia

    Assam El-Osta

  3. Department of Pathology, The University of Melbourne, Parkville, VIC, 3010, Australia

    Assam El-Osta

  4. Central Clinical School, Department of Medicine, Monash University, Melbourne, VIC, 3800, Australia

    Assam El-Osta

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  1. Richard Bayles
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Correspondence to Richard Bayles .

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Editors and Affiliations

  1. Monash Cardiovascular Research Centre, Monash University, Melbourne, Victoria, Australia

    Marlies E. Alvarenga

  2. ANU Medical School, Australia National University, Canberra, Aust Capital Terr, Australia

    Don Byrne

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Bayles, R., El-Osta, A. (2016). Genetics and Epigenetics in Cardiac Psychology. In: Alvarenga, M., Byrne, D. (eds) Handbook of Psychocardiology. Springer, Singapore. https://doi.org/10.1007/978-981-287-206-7_40

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