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Wire chambers revisited

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Abstract

Detectors used for radioisotope imaging have, historically, been based on scintillating crystal/photomultiplier combinations in various forms. From the rectilinear scanner through to modern gamma cameras and positron cameras, the basic technology has remained much the same. Efforts to overcome the limitations of this form of technology have foundered on the inability to reproduce the required sensitivity, spatial resolution and sensitive area at acceptable cost. Multiwire proportional chambers (MWPCs) have long been used as position-sensitive charged particle detectors in nuclear and high-energy physics. MWPCs are large-area gas-filled ionisation chambers in which large arrays of fine wires are used to measure the position of ionisation produced in the gas by the passage of charged particles. The important properties of MWPCs are high-spatial-resolution, large-area, high-count-rate performance at low cost. For research applications, detectors several metres square have been built and small-area detectors have a charged particle resolution of 0.4 mm at a count rate of several million per second. Modification is required to MWPCs for nuclear medicine imaging. As gamma rays or X-rays cannot be detected directly, they must be converted into photo- or Compton scatter electrons. Photon-electron conversion requires the use of high atomic number materials in the body of the chamber. Pressurised xenon is the most useful form of “gas only” photon-electron convertor and has been used successfully in a gamma camera for the detection of gamma rays at energies below 100 keV This camera has been developed specifically for highcount-rate first-pass cardiac imaging. This high-pressure xenon gas MWPC is the key to a highly competitive system which can outperform scintillator-based systems. The count rate performance is close to a million counts per second and the intrinsic spatial resolution is better than the best scintillator-based camera. The MWPC camera produces quantitative ejection fraction information of the highest quality. The detection of higher energy gamma rays has proved more problematical, needing a solid photon-electron convertor to be incorporated into the chamber. Several groups have been working on this problem with modest success so far. The only clinical detectors have been developed for positron emission tomography, where thin lead or lead-glass can provide an acceptable convertor for 511 keV photons. Two MWPC positron cameras have been evaluated clinically and one is now in routine use in clinical oncology. The problems of detection efficiency have not been solved by these detectors although reliability and large-area PET imaging have been proven. The latest development involves a hybrid system in which crystals of barium fluoride are viewed by an MWPC filled with a photosensitive gas. The high detection efficiency of the scintillator is combined with the large sensitive area and good spatial resolution of the MWPC to overcome the limitations of previous MWPC-based positron cameras. The first large-area, clinical camera using this technology is now under development and is expected to perform at least as well as multicrystal positron cameras but at a fraction of the cost.

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References

  1. Lim C, Chu D, Kaufman L, Perez-Mendez V, Hattner R, Price DC. Initial characterization of a multiwire proportional chamber positron camera. IEEE Trans Nucl Sci 1975: NS-22: 388–394.

    Google Scholar 

  2. Bateman JE, Connolly JF, Stephenson R, Flesher AC. The development of the Rutherford Laboratory MWPC positron camera. Nucl Instr Methods 1980; 176:83–88

    Google Scholar 

  3. Jeavons AP, Hood K, Herlin G, Parkman C, Townsend D, Magnanini R, Frey P, Donath A. The high density avalanche chamber for positron emission tomography. IEEE Trans Nucl Sci 1983; NS-30:640–645.

    Google Scholar 

  4. Ott RJ, Marsden PK, Flower MA, Webb S, Cherry S, McCready VR, Bateman JE. Clinical PET with a large area multiwire proportional chamber PET camera. Nucl Instr Methods 1988; A269:436–442.

    Google Scholar 

  5. Del Guerra A, Bandettini A, Conti M, De Pascalis G, Maiano P, Rizzo C. 3-D PET with MWPC's: preliminary tests with the HISPET prototype. Nucl Instr Methods 1988; A269:425–429.

    Google Scholar 

  6. Schotanus P, Van Eijk CWE, Hollander RW. A BaF2-TMAE gamma camera for positron emission tomography. Nucl Instr Methods 1988; A269:377–384.

    Google Scholar 

  7. Mine P, Charpak G, Santiard J-C, Scigocki D. Test of a BaF2-TMAE detector for position emission tomography. Nucl Instr Methods 1988; A269:385–391.

    Google Scholar 

  8. Suckling J, Ott RJ, Marsden PK, Bateman JE, Connolly JF, Stephenson R. A prototype BaF2/TMAE low pressure multiwire proportional chamber for PET. IEEE Trans Nucl Sci 1991; 38(2):703–708.

    Google Scholar 

  9. Lacy JL, LeBlanc AD, Babich JW, Bungo MW, Latson LA, Lewis RM, Poliner LR, Jones RH, Johnson PC. A gamma camera for medical applications using a multiwire proportional counter. J Nucl Med 1984; 25:1003–1012.

    Google Scholar 

  10. Neirinckx RD, Jones AG, Davis MA, Harris GI, Holman BL. Tantalum-178 — a short lived nuclide for nuclear medicine: development of a potential generator system. J Nucl Med 1978; 19:514–519.

    Google Scholar 

  11. Deconinek F, Defrise M, Tavernier S. Wire chambers in medical imaging. Nucl Instr Methods 1988; A269(2)

  12. Lacy JL, Verani MS, Ball ME, Roberts R. Clinical applications of a pressurized xenon wire chamber gamma camera utilizing the short lived agent 178Ta. Nucl Instr Methods 1988; A269:369–376

    Google Scholar 

  13. Lacy JL, Ball ME, Verani MS, Wiles HB, Babich JW, LeBlanc AD, Stabin M, Bolomey L, Roberts R. An improved tungsten-178/tantalum-178 generator system for high volume clinical applications. J Nucl Med 1988; 29:1526–1538.

    Google Scholar 

  14. Lacy JL, Layne WW, Guidry GW, Verani MS, Roberts R. Development and clinical performance of an automated, portable tungsten-178/tantalum-178 generator. J Nucl Med 1991; 32:2158–2161

    Google Scholar 

  15. Frey P, Schaller G, Christin A, Townsend D, Tochon-Danguy H, Wensveen M, Donath A. Clinical applications with the HIDAC positron camera. Nucl Instr Methods 1988; A269:354–361.

    Google Scholar 

  16. Townsend DW. PET with the HIDAC camera? Nucl Instr Methods 1988; A269:443–450.

    Google Scholar 

  17. Flower MA, Ott RJ, Webb S, Leach MO, Marsden PK, Clack R, Khan O, Batty V, McCready VR, Bateman JE. Clinical trials of the prototype Rutherford Appleton Laboratory MWPC positron camera at the Royal Marsden Hospital. Nucl Instr Methods 1988; A269:350–353.

    Google Scholar 

  18. Marsden PK, Ott RJ, Bateman JE, Cherry SR, Flower MA, Webb S. The performance of a multiwire proportinal chamber positron camera for clinical use. Phys Med Biol 1989; 34:1043–1062.

    Google Scholar 

  19. Ott RJ, Batty V, Webb S, Flower MA, Leach MO, Clack R, Marsden PK, McCready VR, Bateman JE, Sharma H, Smith A. Measurement of radiation dose to the thyroid using positron emission tomography. Br J Radiol 1987; 60:245–251.

    Google Scholar 

  20. Flower MA, Schlesinger T, Adam I, Masoomi AM, Hinton PJ, McCready VR. Radiation dose assessment in radioiodine therapy. Part II: Practical implementation using quantitative scanning and PET, with initial clinical results on thyroid carcinoma. Radiother Oncol 1989; 15:345–357.

    Google Scholar 

  21. Flower MA, Irvine AT, Ott RJ, Kabir F, McCready VR, Harmer CL, Sharma HL, Smith AG. Thyroid imaging using positron emission tomography — comparison with ultrasound imaging and conventional scintigraphy in thyrotoxicosis. Br J Radiol 1990; 63:325–330.

    Google Scholar 

  22. Ott RJ, Tait D, Flower MA, Babich JW, Lambrecht RM. Treatment planning for systemic radiotherapy of neural crest tumour using I-124-mIBG positron emission tomography. Br J Radiol 1992;65:787–791.

    Google Scholar 

  23. Ott RJ, Brada M, Flower MA, Babich JW, Cherry SR, Deehan BJ. Measuements of blood-brain-barrier peremability in patients undergoing radiotherapy and chemotherapy for primary cerebral lymphoma. Eur J Cancer 1991; 27:1356–1361.

    Google Scholar 

  24. Lacy JL, Verani MS, Ball ME, Boyce TM, Gibson RW, Roberts R. First-pass radionuclide angiography using a multiwire gamma camera and tantalum-178. J Nucl Med 1988; 29:293–301.

    Google Scholar 

  25. Verani MS, Lacy JL, Guidry GW, Nishimura S, Mahmarian JJ, Athanasoulis T, Roberts R. Quantification of left ventricular performance during transient coronary occlusion at various anatomical sties in humans: a study using tantalum-178 and a multiwire gamma camera. J Am Coll Cardiol 1992; 19:297–306

    Google Scholar 

  26. Anderson DF. A photoionisation detector for the detection of xenon light. IEEE Trans Nucl Sci 1981; NS-28:842–848.

    Google Scholar 

  27. Tavernier S, Bruyndonckx P, Zhang Shupang. A fully 3D small PET scanner. Phys Med Biol 1992; 37:635–643.

    Google Scholar 

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Authors and Affiliations

  1. Joint Department of Physics, Institute of Cancer Research, Royal Marsden Hospital, Sutton, Surrey

    R. J. Ott

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Ott, R.J. Wire chambers revisited. Eur J Nucl Med 20, 348–358 (1993). https://doi.org/10.1007/BF00169813

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