Abstract
We have investigated the role of interferon regulatory factor-1 (IRF-1), an interferon-γ (IFN-γ) inducible transcriptional activator, on major histocompatibility complex (MHC) class I gene transcription. IRF-1 alone is sufficient to trans-activate both transfected and endogenous class I genes and the effect of IRF-1 appears to be direct and sequence-specific. These data suggest that IRF-1 is involved in the IFN-γ mediated induction of MHC class I expression.
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Chang, CH., Hammer, J., Loh, J.E. et al. The activation of major histocompatibility complex class I genes by interferon regulatory factor-1 (IRF-1). Immunogenetics 35, 378–384 (1992). https://doi.org/10.1007/BF00179793
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DOI: https://doi.org/10.1007/BF00179793