Abstract
Administration of morphine HCl (20 mg/kg SC) to male C57B1/6 mice evoked hypermotility. Pretreatment with low doses of the specific D-1 antagonist SCH 23390 (0.006, 0.012, 0.025 mg/kg SC) dose-dependently inhibited morphine-evoked hypermotility. The results suggest that dopamine is the essential mediator of opiate hypermotility and indicate that D-1 receptors play an important role in this effect.
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Longoni, R., Spina, L. & Di Chiara, G. Dopaminergic D-1 receptors: essential role in morphine-induced hypermotility. Psychopharmacology 93, 401–402 (1987). https://doi.org/10.1007/BF00187265
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DOI: https://doi.org/10.1007/BF00187265