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In vitro modulation of natural killer cell activity in non-Hodgkin's lymphoma patients after therapy

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Summary

The depressed natural killer (NK) activity, antibody-dependent cellular cytotoxicity (ADCC) and NK cytotoxic factor cytotoxicity in untreated non-Hodgkin's lymphoma patients were found to be elevated after chemotherapy. In vitro treatment of the effector NK cells with interferon α could augment the NK activity in normal subjects and treated patients to a comparable degree. Chemotherapy mainly affected the post-binding events in the NK cytotoxic process by causing an increase in the active killing potential of the NK cells. This study provides a better understanding of changes in the NK cytotoxic mechanism in non-Hodgkin's lymphoma patients and the role of interferon in this process.

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References

  1. DeVita VT, Jaffe ES, Hellman S (1985) Hodgkin's Disease and the non-hodgkin's lymphomas. In: DeVita VT, Hellman S, Rosenberg SA (eds) Cancer principles and practice of oncology, vol 2. J. B. Lippincott Co., Philadelphia, p 1687

    Google Scholar 

  2. Fornace AT, Jaffe ES (1985) Pathology of malignant lymphomas. In: Wiernik PH, Canellos GP, Kyle RA, Schiffer CA (eds) Neoplastic diseases of the blood. Churchill Livingstone, New York, pp 707–736

    Google Scholar 

  3. Healy F, Rees RC, Hancock BW (1985) An assessment of natural cell mediated cytotoxicity in patients with malignant lymphoma. Eur J Cancer Clin Oncol 21:775

    Google Scholar 

  4. Herberman RB (1982) Immunoregulation and natural killer cells. Mol Immunol 19:1313

    Google Scholar 

  5. Hiserodt JC, Britvan L, Targan SR (1983) Studies on the mechanism of the human natural killer cell lethal hit: analysis of the mechanisms of protease inhibition of the lethal hit. J Immunol 131:2705

    Google Scholar 

  6. Keegan P, Ozer H (1985) Immunology of the lymphomas. In: Wiernik PH, Canellos GP, Kyle RA, Schiffer CA (eds) Neoplastic diseases of the blood, vol. 2, Churchill Livingstone, New York, p 748

    Google Scholar 

  7. Mehta BA, Advani SH, Nadkarni JJ (1988) Natural killer activity and antibody-dependent cellular cytotoxicity in patients with non-Hodgkin's lymphoma. Neoplasma 35:61

    Google Scholar 

  8. Patel GV, Satam MN, Gopal R, Nadkarni JJ (1986) Isolation and dissociation of immune complexes from pleural effusions of lymphoma patients. Cancer Immunol Immunother 23:51

    Google Scholar 

  9. Perlmann P, Perlmann H (1970) Contactual lysis of antibody coated chicken erythrocytes by purified lymphocytes. Cell Immunol 1:300

    Google Scholar 

  10. Rappaport H (1966) Tumors of the hematopoietic system. In: Atlas of tumor pathology, section 3, fascimile 8, Armed Forces Institute of Pathology, Washington DC, p 13

    Google Scholar 

  11. Roozemond RC, Mevissen M, Urli DC, Bonavida B (1987) Effect of altered membrane structure on NK cell-mediated cytotoxicity III. Decreased susceptibility to natural killer cytotoxic factor (NKCF) and suppression of NKCF release by membrane rigidification. J Immunol 139:1739

    Google Scholar 

  12. Satam MN, Suraiya JN, Nadkarni JJ (1986) Natural killer and antibody-dependent cellular cytotoxicity in cervical carcinoma patients. Cancer Immunol Immunother 23:56

    Google Scholar 

  13. Sherman CD, Colman FC, Eckhardt S, Elsebai I, Firat D, Hossfeld DK, Paunier JP, Salvadori B (eds) (1987) Lymphomas and myeloma. In: Manual of clinical oncology, Springer-Verlag, Berlin, p 281

    Google Scholar 

  14. Steinhauer EH, Doyle AT, Reed J, Kadish AS (1982) Defective natural cytotoxicity in patients with cancer: normal number of effector cells but decreased recycling capacity in patients with advanced disease. J Immunol 129:2255

    Google Scholar 

  15. Targan S, Dorey F (1980) Interferon activation of prespontaneous killer (pre-SK) cells and alteration in kinetics of lysis of both “pre-SK” and active SK cells. J Immunol 124:2157

    Google Scholar 

  16. Timonen T, Ortaldo JR, Herberman RB (1981) Characteristics of human larger granular lymphocytes and relationship to natural killer and K cells. J Exp Med 153:569

    Google Scholar 

  17. Uchida A, Klein E (1985) Natural cytotoxicity of human blood monocytes and natural killer cells and their cytotoxic factors: discriminating effects of actinomycin D. Int J Cancer 35:691

    Google Scholar 

  18. Uchida A, Yanagawa E (1984) Natural cytotoxicity of human blood monocytes: production of monocyte cytotoxic factors (MCF) during interaction with tumor cells. Immunol Lett 8:311

    Google Scholar 

  19. Uchida A, Vankey F, Klein E (1985) Natural cytotoxicity of human blood lymphocytes and monocytes and their cytotoxic factors: effect of interferon on target cell susceptibility. J Natl Cancer Inst 75:849

    Google Scholar 

  20. Ullberg M, Jondal M (1981) Recycling and target binding capacity of human natural killer cells. J Exp Med 153:615

    Google Scholar 

  21. Vargas-Cortes M, Hellstrom U, Perlmann P (1983) Surface markers of human natural killer cells as analysed in a modified single cell cytotoxicity assay on poly-L-lysine coated coverslips. J Immunol Methods 62:87

    Google Scholar 

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Authors and Affiliations

  1. Cancer Research Institute Immunology Division, India

    Bela A. Mehta, Mangesh N. Satam & Jayshree J. Nadkarni

  2. Tata Memorial Hospital, Tata Memorial Centre, Parel, 400 012, Bombay, India

    Suresh H. Advani

Authors
  1. Bela A. Mehta
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  2. Mangesh N. Satam
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  3. Suresh H. Advani
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  4. Jayshree J. Nadkarni
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Additional information

B. A. Mehta is a recipient of the Lady Tata Memorial Trust, India, Senior Scholarship

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Mehta, B.A., Satam, M.N., Advani, S.H. et al. In vitro modulation of natural killer cell activity in non-Hodgkin's lymphoma patients after therapy. Cancer Immunol Immunother 28, 148–152 (1989). https://doi.org/10.1007/BF00199116

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  • DOI: https://doi.org/10.1007/BF00199116

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