Summary
The ontogenesis of small intensely fluorescent (SIF) cells and the adrenergic nerve plexus is described in stretch preparations of the rabbit portal vein. On the 25 to 26th days of gestation there was a predominance of SIF cells (8 to 30 μm in diameter), but a few nerve fibres in bundles were also present. Each portal vein preparation contained 6 to 9 groups of cells. The distribution and number of SIF cells and nerve bundles remained constant until the 31st day of gestation at which stage the number of SIF cells had decreased, while the density of the nerve plexus had increased approximately 4-fold. The adult portal vein exhibited a dense adrenergic plexus, but SIF cells were absent from nine out of ten preparations.
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References
Andrew W (1959) Textbook of comparative histology. Oxford University Press, Oxford, p 528
Axelsson S, Björklund A, Falck B, Lindvall O, Svensson L-A (1973) Glyoxylic acid condensation: a new fluorescence method for the histochemical demonstration of biogenic monoamines. Acta Physiol Scand 87:57–62
Brundin T (1966) Studies on the preaortal paraganglia of newborn rabbits. Acta Physiol Scand 70: Suppl 290 1–54
Burnstock G (1969) Evolution of the autonomic innervation of visceral and cardiovascular systems in vertebrates. Pharmacol Rev 21:247–324
Burnstock G, Costa M (1975) Adrenergic neurons: their organisation, function and developement in the peripheral nervous system. Chapman and Hall, London, p 225
Burnstock G, Evans B, Gannon BJ, Heath J, James V (1971) A new method for destroying adrenergic nerves in adult animals using guanethidine. Br J Pharmacol 43:295–301
Burnstock G, Crowe R, Wong H (1979) Comparative pharmacological and histochemical evidence for purinergic inhibitory innervation of the portal vein of the rabbit but not guinea-pig. Br J Pharmacol 65:377–388
Costa M, Eränkö L, Eränkö O (1973) Effect of hydrocortisone on the extraadrenal intensely fluorescent chromaffin and non-chromaffin cells in stretch preparations of the newborn rat. Z Zellforsch 146:565–578
Coupland RE (1965) The natural history of the chromaffin cell. Longmans Green, New York
De Champlain J, Malmfors T, Olson L, Sachs CH (1970) Ontogenesis of peripheral adrenergic neurones in the rat: pre-and post-natal observations. Acta Physiol Scand 80:276–288
Enemar A, Falck B, Håkanson R (1965) Observations on the appearance of norepinephrine in the sympathetic nervous system of the chick embryo. Dev Biol 11:268–283
Eränkö O, Eränkö L (1971) Small, intensely fluorescent granule-containing cells in the sympathetic ganglion of the rat. Prog Brain Res 34:39–51
Eränkö O, Harkönen H (1963) Histochemical demonstration of fluorogenic amines in the cytoplasm of sympathetic ganglion cells of the rat. Acta Physiol Scand 58:285–286
Falck B, Hillarp NÅ, Thieme G, Torp A (1962) Fluorescence of catecholamines and related compounds condensed with formaldehyde. J Histochem Cytochem 10:348–354
Friedman WF, Pool PE, Jacobowitz D, Seagren SC, Braundwald E (1968) Sympathetic innervation of the developing rabbit heart. Circ Res 23:25–32
Furness JB, McLean JR, Burnstock G (1970) Distribution of adrenergic nerves and changes in neuromuscular transmission in the mouse vas deferens during post-natal development. Dev Biol 21:491–505
Gabella G (1976) The structure of the autonomic nervous system. Chapman and Hall, London
Gallen DD, Cowen T, Griffith SG, Haven AJ, Burnstock G (1982) Functional and non-functional nerve-smooth muscle transmission in the renal arteries of the newborn and adult rabbit and guineapig. Blood Vessels 19:237–246
Gershon MD, Thompson EB (1976) The maturation of neuromuscular function in a multiply innervated structure: development of the longitudinal smooth muscle of the foetal mammalian gut and its cholinergic exitatory, adrenergic inhibitory and non-adrenergic inhibitory innervation. J Physiol (Lond) 234:257–277
Hervonen A (1971) Development of catecholamine storing cells in human fetal paraganglia and adrenal medulla. Acta Physiol Scand Suppl 368:1–94
Lempinen M (1964) Extra-adrenal chromaffin tissue of the rat and the effect of cortical hormones on it. Acta Physiol Scand 62: Suppl 231:1–91
Lundenberg J, Ljung B, Stage D, Dahlström A (1976) Post-natal ontogenic development of the adrenergic innervation pattern in the rat portal vein. Cell Tissue Res 172:15–27
Machado ABM (1971) Electron microscopy of developing sympathetic fibres in the rat pineal body. The formation of granular vesicles. Prog Brain Res 34:171–185
Malmfors T, Furness JB, Campbell GR, Burnstock G (1971) Reinnervation of smooth muscle of the vas deferens transplanted into the interior chamber of the eye. J Neurobiol 2:193–207
Matthews MR, Raisman G (1969) A light and electron microscopic study of the cellular response to axonal injury in the superior cervical ganglion of the rat. Proc R Soc Lond (Biol) 181:43–79
McLean JR, Burnstock G (1966) Histochemical localization of catecholamines in the urinary bladder of the toad (Bufo marinus). J Histochem Cytochem 14:538–548
Pappano AJ, Löffelholtz K (1974) Ontogenesis of adrenergic and cholinergic neuroeffector transmission in chick embryo heart. J Pharmacol Exp Ther 191:468–478
Papka RE (1972) Ultrastructural and fluorescence histochemical studies of developing sympathetic ganglia in the rabbit. Am J Anat 134:337–364
Pearse AGE (1972) Histochemistry, theoretical and applied. 3rd ed. Vol 2. Churchill Livingstone, Edinburgh London
Read JB, Burnstock G (1970) Development of the adrenergic innervation and chromaffin cells in the human fetal gut. Dev Biol 22:513–534
Santer RM (1977) Monoaminergic nerves in the central and peripheral nervous systems of fishes. Gen Pharmacol 8:157–172
Su C, Bevan JA, Assali NS, Brinkman CR (1977) Development of neuroeffector mechanism in the carotid artery of the foetal lamb. Blood Vessels 14:12–24
Taxi J (1979) The chromaffin and chromaffin-like cells in the autonomic nervous system. Int Rev Cytol 57:283–343
Williams TH, Black JAC, Chiba T, Jew J (1976) Interneurons/SIF cells in sympathetic ganglia of various mammals. In: Coupland RE, Fujita T (eds) Chromaffin, enterochromaffin and related cells. Elsevier Scientific Publishing Company, Amsterdam Oxford New York, p 95
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Crowe, R., Burnstock, G. Small intensely fluorescent (SIF) cells and sympathetic nerves in the adult rabbit portal vein and during perinatal development. Cell Tissue Res. 227, 601–607 (1982). https://doi.org/10.1007/BF00204790
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DOI: https://doi.org/10.1007/BF00204790