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The relationship between gastrin cells and bombesin-like immunoreactive nerve fibres in the gastric antral mucosa of guinea-pig, rat, dog and man

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Summary

The relationship between bombesin-like immunoreactive (bombesin-LI) nerve fibres and gastrin-LI G-cells was examined in gastric antral mucosa from guineapig, rat, dog and man using a double-labelling fluorescence immunohistochemical technique. The greatest density of bombesin-LI nerve fibres was found within the basal mucosa in all species and the density of innervation decreased towards the luminal surface. Most G-cells were in a band occupying approximately the middle third of the mucosa. The proportion of G-cells found within a distance of 2 μm from bombesin-LI nerve fibres was low in all species (6% in the guinea-pig, 22% in the rat, 14% in the dog, and 9% in the human). It is proposed that the neuropeptide released from bombesin-LI antral mucosal nerve fibres traverses distances of greater than several μm to reach the target G-cells. This may be achieved by passage through the mucosal microcirculation.

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Authors and Affiliations

  1. Departments of Physiology and of Anatomy and Histology, Centre for Neuroscience, School of Medicine, Flinders University of South Australia, Bedford Park, South Australia, Australia

    A. S. Miller, J. B. Furness & M. Costa

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  1. A. S. Miller
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  2. J. B. Furness
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  3. M. Costa
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Miller, A.S., Furness, J.B. & Costa, M. The relationship between gastrin cells and bombesin-like immunoreactive nerve fibres in the gastric antral mucosa of guinea-pig, rat, dog and man. Cell Tissue Res. 257, 171–178 (1989). https://doi.org/10.1007/BF00221648

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