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The sarcoplasmic reticulum Ca2+-ATPase

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Summary

This review summarizes studies on the structural organization of Ca2+-ATPase in the sarcoplasmic reticulum membrane in relation to the function of the transport protein. Recent advances in this field have been made by a combination of protein-chemical, ultrastructural, and physicochemical techniques on membraneous and detergent solubilized ATPase. A particular feature of the ATPase (Part I) is the presence of a hydrophilic ‘head’, facing the cytoplasm, and a ‘tail’ inserted in the membrane. In agreement with this view the protein is moderately hydrophobic, compared to many other integral membrane proteins, and the number of traverses of the 115 000 Dalton peptide chain through the lipid may be limited to 3–4.

There is increasing evidence (Part II) that the ATPase is self-associated in the membrane in oligomeric form. This appears to be a common feature of many transport proteins. Each ATPase peptide seems to be able to perform the whole catalytic cycle of ATP hydrolysis and Ca2+ transport. Protein-protein interactions seem to have a modulatory effect on enzyme activity and to stabilize the enzyme against inactivation.

Phospholipids (Part III) are not essential for the expression of enzyme activity which only requires the presence of flexible hydrocarbon chains that can be provided e.g. by polyoxyethylene glycol detergents. Perturbation of the lipid bilayer by the insertion of membrane protein leads to some immobilization of the lipid hydrocarbon chains, but not to the extent envisaged by the annulus hypothesis. Strong immobilization, whenever it occurs, may arise from steric hindrance due to protein-protein contacts. Recent studies suggest that breaks in Arrhenius plots of enzyme activity primarily reflect intrinsic properties of the protein rather than changes in the character of lipid motion as a function of temperature.

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Authors and Affiliations

  1. Institute of Medical Biochemistry, University of Aarhus, 8000, Aarhus C, Denmark

    Moller J. V. & Andersen J. P.

  2. Centre de Genetique Moleculaire du C.N.R.S., 91190, Gif sur Yvette, France

    Maire M. le

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Moller, J.V., Andersen, J.P. & le Maire, M. The sarcoplasmic reticulum Ca2+-ATPase. Mol Cell Biochem 42, 83–107 (1981). https://doi.org/10.1007/BF00222696

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