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Regulation of liver and brain hexose monophosphate dehydrogenases by insulin and dietary intake in the female rat

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Summary

Liver glucose 6-phosphate dehydrogenase and phosphogluconate dehydrogenase activities were significantly decreased in both diabetic and fasted rats. Treatment of diabetic rats with insulin resulted in liver glucose 6-phosphate dehydrogenase and phosphogluconate dehydrogenase activities that were significantly greater than controls. Insulin promoted an increase in food consumption that was blocked by adrenaline. Insulin, when administered together with adrenaline, restored hepatic glucose 6-phosphate dehydrogenase and phosphogluconate dehydrogenas activities of diabetic animals to control values, without altering food consumption. Brain glucose 6-phosphate dehydrogenase and phosphogluconate dehydrogenase activities were not significantly altered by either dietary restriction, diabetes or insulin treatment. These results demonstrate a dissociation between the action of insulin on hepatic glucose 6-phosphate dehydrogenase activity and its action to increase food intake.

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Abbreviations

NADP+ oxidoreductase, EC 1.1.1.49:

Glucose 6-P dehydrogenase, GPD, D-glucose-6-phosphate

NADP+ 2-oxidoreductase (decarboxylating), EC 1.1.1.44:

phosphogluconate dehydrogenase, PGD, 6-phospho-D-gluconate

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Authors and Affiliations

  1. Laboratory of Molecular and Applied Neuropathology, University of Western Australia, 6009, Nedlands, Western Australia, Australia

    Ralph N. Martins, Gilbert B. Stokes & Colin L. Masters

  2. Neuromuscular Research Institute, Department of Pathology, University of Western Australia, 6009, Nedlands, Western Australia, Australia

    Ralph N. Martins & Colin L. Masters

  3. Department of Biochemistry, University of Western Australia, 6009, Nedlands, Western Australia, Australia

    Gilbert B. Stokes

Authors
  1. Ralph N. Martins
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  2. Gilbert B. Stokes
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  3. Colin L. Masters
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Martins, R.N., Stokes, G.B. & Masters, C.L. Regulation of liver and brain hexose monophosphate dehydrogenases by insulin and dietary intake in the female rat. Mol Cell Biochem 70, 169–175 (1986). https://doi.org/10.1007/BF00229431

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  • DOI: https://doi.org/10.1007/BF00229431

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