Summary
Sympathetic nerves in vitro form long-lasting, intimate, functional relationships with cardiac muscle cells, but not with fibroblasts. In the presence of an adrenergic β-blocker and a cholinergic muscarinic blocker, long-lasting relationships still take place. It was concluded that neurotransmitter ‘receptors’ are not involved in the mechanism of ‘recognition’ of cardiac muscle cells by sympathetic nerves.
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Campbell, G.R., Chamley, J.H. & Burnstock, G. Lack of effect of receptor blockers on the formation of long-lasting associations between sympathetic nerves and cardiac muscle cells in vitro. Cell Tissue Res. 187, 551–553 (1978). https://doi.org/10.1007/BF00229619
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DOI: https://doi.org/10.1007/BF00229619