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Influence of thyroid hormone on the development of preoptic-hypothalamic monoaminergic neurons in tadpoles of Bufo bufo japonicus

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Summary

The effect of thyroid hormone on the development of diencephalic monoaminergic neurons was studied in tadpoles of Bufo bufo japonicus. Monoamine-containing neurons in the preoptic recess organ (PRO) appeared later than those in the paraventricular organ (PVO) and nucleus infundibularis dorsalis (NID). After deprivation of thyroidal primordium no fluorescent neurons developed in the PRO. Development of monoaminergic neurons in the PVO and NID was not affected by thyroidectomy. Thyroxine treatment brought about the fluorescent neurons in the PRO of the thyroidectomized tadpoles. Fluorescent terminals in the median eminence became conspicuous around the capillaries which penetrated to the median eminence, when the tadpoles reached late prometamorphic stage. In the median eminence of thyroidectomized tadpoles, the monoaminergic axon terminals did not develop. Thyroxine induced both the fluorescent terminals and the capillary penetration in the median eminence of the thyroidectomized tadpoles. In the tadpoles hypophysectomized at tail-bud stage, thyroxine induced neither the fluorescent terminals nor the capillaries in the median eminence.

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Authors and Affiliations

  1. Department of Biology, School of Education, Waseda University, 160, Tokyo, Japan

    Sakaé Kikuyama, Momoko Miyakawa & Yasumasa Arai

  2. Department of Anatomy, Juntendo University School of Medicine, Kongo, Tokyo, Japan

    Sakaé Kikuyama, Momoko Miyakawa & Yasumasa Arai

Authors
  1. Sakaé Kikuyama
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  2. Momoko Miyakawa
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  3. Yasumasa Arai
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Supported by grants from the Ministry of Education of Japan and Waseda University

The authors heartily thank Prof. B. Scharrer for critical reading the manuscript

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Kikuyama, S., Miyakawa, M. & Arai, Y. Influence of thyroid hormone on the development of preoptic-hypothalamic monoaminergic neurons in tadpoles of Bufo bufo japonicus . Cell Tissue Res. 198, 27–33 (1979). https://doi.org/10.1007/BF00234831

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  • DOI: https://doi.org/10.1007/BF00234831

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