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The rubrospinal tract. I. Effects on alpha-motoneurones innervating hindlimb muscles in cats

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Summary

  1. 1.

    The effect of stimulation of the red nucleus on lumbosacral motoneurones was investigated in cats with conditioning of monosynaptic test reflexes and intracellular recording.

  2. 2.

    Experimental procedures were adopted to assure that the effect of stimulation was mediated by the rubrospinal tract.

  3. 3.

    Excitation of flexor and inhibition of extensor motoneurones is common but a mixture of EPSPs and IPSPs is found in many motoneurones. In some extensor (particularly toe extensor) motor nuclei there is dominating excitation.

  4. 4.

    Differential effects are found in motor nuclei innervating fast and slow muscles, excitation being more prevalent in the former and inhibition in the latter.

  5. 5.

    For both EPSPs and IPSPs the minimal synaptic linkage is disynaptic but in one exceptional case a monosynaptic EPSP was observed.

  6. 6.

    The results are discussed in relation to other findings regarding the interneuronal organization in the spinal cord.

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References

  • Angaut, P., and D. Bowsher: Cereballo-rubral connexions in the cat. Nature (Lond.) 208, 1002–1003 (1965).

    Google Scholar 

  • Asanuma, H., and H. Sakata: Functional organization of a cortical efferent system examined with focal depth stimulation in cats. J. Neurophysiol. 30, 35–54 (1967).

    Google Scholar 

  • Brodal, A., and A.C. Gogstad: Rubro-cerebellar connections. An experimental study in the cat. Anat. Rec. 118, 455–485 (1954).

    Google Scholar 

  • —, and F. Walberg: Anatomical studies of some corticofugal connections to the brain stem. In: Structure and Function of the Cerebral Cortex, pp. 116–123. Ed. by D.B. Tower and J.P. Schadé. Amsterdam: Elsevier 1960.

    Google Scholar 

  • Burke, R.E.: Group Ia synaptic input to fast and slow twitch motor units of cat triceps surae. J. Physiol. (Lond.) 196, 605–630 (1968).

    Google Scholar 

  • Carpenter, D., I. Engberg and A. Lundberg: Primary afferent depolarization evoked from the brain stem and the cerebellum. Arch. ital. Biol. 104, 73–85 (1966).

    Google Scholar 

  • Eccles, J.C., R.M. Eccles, A. Iggo and M. Ito: Distribution of recurrent inhibition among motoneurones. J. Physiol. (Lond.) 159, 479–499 (1961).

    Google Scholar 

  • —, and A. Lundberg: The convergence of monosynaptic excitatory afferents on to many different species of alpha motoneurones. J. Physiol. (Lond.) 137, 22–50 (1957).

    Google Scholar 

  • Eccles, R.M., and A. Lundberg: Integrative pattern of Ia synaptic actions on motoneurones of hip and knee muscles. J. Physiol. (Lond.) 144, 271–298 (1958).

    Google Scholar 

  • — Synaptic actions in motoneurones by afferents which may evoke the flexion reflex. Arch. ital. Biol. 97, 199–221 (1959).

    Google Scholar 

  • Eide, E., A. Lundberg and P. Voorhoeve: Monosynaptically evoked inhibitory postsynaptic potentials in motoneurones. Acta physiol. scand. 53, 185–195 (1961).

    Google Scholar 

  • Engberg, I.: Reflexes to foot muscles in the cat. Acta physiol. scand. 62, Suppl. 235 (1964).

    Google Scholar 

  • —, A. Lundberg and R.W. Ryall: Reticulospinal inhibition of transmission in reflex pathways. J. Physiol. (Lond.) 194, 201–223 (1968).

    Google Scholar 

  • Evans, B.H., and W.R. Ingram: The effect of combined red nucleus and pyramidal lesions in cats. J. comp. Neurol. 70, 461–476 (1939).

    Google Scholar 

  • Granit, R., H.D. Henatsch and G. Steg: Tonic and phasic ventral horn cells differentiated by post-tetanic potentiation in cat extensors. Acta physiol. scand. 37, 114–126 (1956).

    Google Scholar 

  • —, C.G. Phillips, S. Skoglund and G. Steg: Differentiation of tonic from phasic alpha ventral horn cells by stretch, pinna and crossed extensor reflexes. J. Neurophysiol. 20, 470–481 (1957).

    Google Scholar 

  • Grillner, S., T. Hongo and S. Lund: Reciprocal effects between two descending bulbospinal systems with monosynaptic connections to spinal motoneurones. Brain Res. 10, 477–480 (1968).

    Google Scholar 

  • —, and S. Lund: A descending pathway with monosynaptic action on flexor motoneurones. Experientia (Basel) 22, 390 (1966).

    Google Scholar 

  • — The origin of a descending pathway with monosynaptic action on flexor motoneurones. Acta physiol. scand. 74, 274–284 (1968).

    Google Scholar 

  • Henneman, E., G. Somjen and D. Carpenter: Excitability and inhibitibility of motoneurons of different sizes. J. Neurophysiol. 28, 599–620 (1965).

    Google Scholar 

  • Hinman, A., and M.B. Carpenter: Efferent fiber projection of the red nucleus in the cat. J. comp. Neurol. 113, 61–82 (1959).

    Google Scholar 

  • Holmqvist, B., and A. Lundberg: Differential supraspinal control of synaptic actions evoked by volleys in the flexion reflex afferents in alpha motoneurones. Acta physiol. scand. 54, Suppl. 186, (1961).

    Google Scholar 

  • Hongo, T., E. Jankowska and A. Lundberg: Effects evoked from the rubrospinal tract in cats. Experientia (Basel) 21, 525–526 (1965).

    Google Scholar 

  • — The rubrospinal tract. II. Facilitation of interneuronal transmission in reflex paths to motoneurones. Exp. Brain Res. 7, 365–391 (1969).

    Google Scholar 

  • Ingram, W.R., and S.W. Ranson: Effects of lesions in the red nuclei in cats. Arch. Neurol. Psychiat. (Chic.) 28, 483–512 (1932a).

    Google Scholar 

  • — The place of the red nucleus in the postural complex. Amer. J. Physiol. 102, 466–475 (1932b).

    Google Scholar 

  • Jankowska, E., S. Lund, A. Lundberg and O. Pompeiano: Inhibitory effects evoked through ventral reticulospinal pathways. A Biol. (1968) (in press).

  • Kostyuk, P.G., and A.J. Pilyavsky: Postsynaptic potentials in spinal motoneurons under rubrospinal influences. Zh. vyssh. nerv. Deyat. Pavlova 17, 497–504 (1967).

    Google Scholar 

  • Kuno, M.: Excitability following antidromic activation in spinal motoneurones supplying red muscles. J. Physiol. (Lond.) 149, 347–393 (1959).

    Google Scholar 

  • Kuypers, H.G.J.M.: An anatomical analysis of corticobulbar connexions to the pons and lower brain stem in the cat. J. Anat. (Lond.) 92, 198–218 (1958).

    Google Scholar 

  • Lund, S., and O. Pompeiano: Monosynaptic excitation of alpha motoneurones from supraspinal structures in the cat. Acta physiol. scand. 73, 1–21 (1968).

    Google Scholar 

  • Lundberg, A.: Integration in the reflex pathway. In: Muscular Afferents and Motor Control. Nobel Symposium 1, pp. 275–305. Stockholm: Almqvist & Wiksell 1966.

    Google Scholar 

  • —, and P. Voorhoeve: Effects from the pyramidal tract on spinal reflex arcs. Acta physiol. scand. 56, 201–219 (1962).

    Google Scholar 

  • Maffei, L., and O. Pompeiano: Effects of stimulation of the mesencephalic tegmentum following interruption of the rubrospinal tract. Arch. ital. Biol. 100, 510–525 (1962).

    Google Scholar 

  • Massion J.: The mammalian Red Nucleus. Physiological Reviews 47, 383–436 (1967).

    Google Scholar 

  • Nyberg-Hansen, R., and A. Brodal: Sites and mode of termination of rubrospinal fibers in the cat. J. Anat. (Lond.) 98, 235–253 (1964).

    Google Scholar 

  • Pompeiano, O.: Analisi degli effetti della stimolazione elettrica del nucleo rosso nel gatto decerebrato. Rend. Accad. Nazl. Lincei 22, Ser. VIII, 100–103 (1957).

    Google Scholar 

  • —, and A. Brodal: Experimental demonstration of a somatotopical origin of rubrospinal fibers in the cat. J. comp. Neurol. 108, 225–251 (1957).

    Google Scholar 

  • Preston, J.B., and D.G. Whitlock: A comparison of motor cortex effects on slow and fast muscle innervations in the monkey. Exp. Neurol. 7, 327–341 (1963).

    Google Scholar 

  • Rinvik, E., and F. Walberg: Demonstration of a somatotopically arranged cortico-rubral projection in the cat. J. comp. Neurol. 120, 393–407 (1963).

    Google Scholar 

  • Sasaki, K., A. Namikawa and S. Hashiramoto: The effect of midbrain stimulation upon alpha motoneurones in lumbar spinal cord of the cat. Jap. J. Physiol. 10, 303–316 (1960).

    Google Scholar 

  • Shapovalov, A.I.: Excitation and inhibition of spinal neurones during supraspinal stimulation. In: Muscular Afferents and Motor Control. Nobel Symposium 1, pp. 331–348. Stockholm: Almqvist & Wiksell 1966.

    Google Scholar 

  • —, and K.B. Shapovalova: Activity of α-motoneurones during rhythmical stimulation of red nucleus and effects of strychnine on rubrospinal influence. Dokl. Akad. Nauk SSSR, cited in Shapovalov, A.I.: Excitation and inhibition of spinal neurones during supraspinal stimulation. In: Muscular Afferents and Motor Control. Nobel Symposium 1, pp. 331–348. Stockholm: Almqvist & Wiksell 1966.

    Google Scholar 

  • Thulin, C.A.: Effects of electrical stimulation of the red nucleus on the alpha motor system. Exp. Neurol. 7, 464–484 (1963).

    Google Scholar 

  • Tsukahara, N., and K. Kosaka: The mode of cerebral activation of the red nucleus neurones. Experientia (Basel) 22, 193–194 (1966).

    Google Scholar 

  • —, K. Toyama and K. Kosaka: Electrical activity of red nucleus neurones investigated with intracellular microelectrodes. Exp. Brain Res. 4, 18–33 (1967).

    Google Scholar 

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Authors and Affiliations

  1. Department of Physiology, University of Göteborg, Göteborg, Sweden

    T. Hongo,  Elżbieta Jankowska & A. Lundberg

  2. Department of Physiology, Tokyo Medical and Dental University, 1-Chome, Yushima, Bunkyo-ku, Tokyo, Japan

    T. Hongo

  3. Department of Neurophysiology, Nencki Institute of Experimental Biology, 3, Pasteur Street, 22, Warsaw, Poland

    Elżbieta Jankowska

Authors
  1. T. Hongo
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  2. Elżbieta Jankowska
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  3. A. Lundberg
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Additional information

This is the first of a series of four papers. The remaining papers describe rubrospinal effects on: interneuronal transmission in reflex paths (II), primary afferent terminals (III), interneurones (IV).

This work has been supported by the Swedish Medical Research Council (Projects No. 14X-94-03B and 14X-94-04C).

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Hongo, T., Jankowska, E. & Lundberg, A. The rubrospinal tract. I. Effects on alpha-motoneurones innervating hindlimb muscles in cats. Exp Brain Res 7, 344–364 (1969). https://doi.org/10.1007/BF00237320

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  • DOI: https://doi.org/10.1007/BF00237320

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