Summary
Stimulation of the vestibular nerve induced EPSPs monosynaptically in 29% of cat's Deiters neurones sampled on the ipsilateral side. These EPSPs started with latencies of 0.6–1.0 msec, rose sharply with a summit time of 0.5 msec and decayed exponentially with a time constant of 0.9–1.7 msec. Then amplitudes were graded finely according to the intensity of the vestibular nerve stimulation, the maximal size being 5–10 mV. The unitary EPSPs, evoked by vestibular nerve stimulation at juxta-threshold intensity or appearing spontaneously, were as small as 0.2–0.3 mV in amplitude. Those neurones monosynaptically activated by vestibular nerve volleys were located in the ventral portion of the nucleus of Deiters, in agreement with histological data. The vestibular nerve impulses also produced delayed EPSPs with latencies of 1.0–1.8 msec, presumably disynaptically. They occurred in many Deiters neurones located not only ventrally but also dorsally. Even later EPSPs often were superposed on the monosynaptic EPSPs with latencies of 1.9–2.2 msec. There is evidence that they were caused by repetitive discharges in the vestibular nerve fibres which occur in response to single shock stimulation of the vestibular nerve. IPSPs were produced only polysynaptically in some Deiters neurones in association with the monosynaptic EPSPs.
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Andersen, P., J.C. Eccles, T. Oshima and R.F. Schmidt: Mechanisms of synaptic transmission in the cuneate nucleus. J. Neurophysiol. 27, 1096–1116 (1964).
Andersson, S., and B.E. Gernandt: Cortical Projection of vestibular nerve in cat. Acta oto-laryng. (Stockh.) 116, 10–18 (1954).
Araki, T., J.C. Eccles and M. Ito: Correlation of the inhibitory postsynaptic potential of motoneurones with the latency and time course of inhibition of monosynaptic reflexes. J. Physiol. (Lond.) 154, 354–377 (1960).
Brock, L.G., J.S. Coombs and J.C. Eccles: The recording of potentials from motoneurones with an intracellular electrode. J. Physiol. (Lond.) 117, 431–460 (1952).
Brodal, A., O. Pompeiano and F. Walberg: The vestibular nuclei and their connections. Anatomy and functional cerrelations. Edinburgh-London: Oliver and Boyd 1962.
Burke, R.E.: Composite nature of the monosynaptic excitatory postsynaptic potential. J. Neurophysiol. 30, 1114–1137 (1967).
Coombs, J.S.: Some methods of reducing interference caused by stimulus artifacts. In: Studies in Physiology, pp. 29–33. Ed. by D.R. Curtis and A.K. McIntyre. Berlin-Heidelberg-New York: Springer 1965.
—, D.R. Curtis and J.C. Eccles: The generation of impulses in motoneurones. J. Physiol. (Lond.) 139, 232–249 (1957).
—, J.C. Eccles and P. Fatt: The electrical properties of the motoneurone membrane. J. Physiol. (Lond.) 30, 291–325 (1955).
Curtis, D.R., and J.C. Eccles: The time course of excitatory and inhibitory synaptic actions. J. Physiol. (Lond.) 145, 529–546 (1959).
del Castillo, J., and B. Katz: Quantal components of the endplate potential. J. Physiol. (Lond.) 124, 560–573 (1954).
de Vito, R.V., A. Brusa and A. Arduini: Cerebellar and vestibular influences on Deitersian units. J. Neurophysiol. 19, 241–253 (1956).
Eccles, J.C., R.M. Eccles and A. Lundberg: Types of neurones in and around the intermediate nucleus of the lumbo-sacral cord. J. Physiol. (Lond.) 154, 89–114 (1960).
—, J.I. Hubbard and O. Oscarrson: Intracellular recording from cells of the ventral spinocerebellar tract, J. Physiol. (Lond.) 158, 486–516 (1961).
—, O. Oscarsson and W.D. Willis: Synaptic action of Group I and II afferent fibres of muscle on the cells of the dorsal spinocerebellar tract. J. Physiol. (Lond.) 158, 517–543 (1961).
Eccles, R.M., and A. Lundberg: Integrative patterns of Ia synaptic action on motoneurones of hip and knee muscles. J. Physiol. (Lond.) 144, 271–298 (1958).
Fuortes, M.G.F., K. Frank and M.C. Becker: Steps in the production of motoneurone spikes. J. gen. Physiol. 40, 735–752 (1957).
Hongo, T., E. Jankowska and A. Lundberg: Convergence of excitatory and inhibitory action on interneurones in the lumbosacral cord. Exp. Brain Res. 1, 338–358 (1966).
Ito, M., T. Hongo, M. Yoshida, Y. Okada and K. Obata: Intracellularly recorded antidromic responses of Deiters neurones. Experientia (Basel) 20, 295–296 (1964a).
— Antidromic and trans-synaptic activation of Deiters neurones induced from the spinal cord. Jap. J. Physiol. 14, 638–658 (1984b).
—, N. Kawai and M. Udo: The origin of cerebellar-induced inhibition of Deiters neurones. III. Localization of the inhibitory zone. Exp. Brain Res. 4, 310–320 (1968).
Kuno, M.: Quantal components of excitatory synaptic potentials in spinal motoneurones. J. Physiol. (Lond.) 175, 81–99 (1964).
Lorente de Nó, R.: Anatomy of the eighth nerve. The central projection of the nerve endings of the internal ear. Laryngoscope (St. Louis) 43, 1–38 (1933).
Mugnaini, E., F. Walbeeg and A. Brodal: Mode of termination of primary vestibular fibres in the lateral vestibular nucleus. An experimental electron microscopical study in the cat. Exp. Brain Res. 4, 187–211 (1967).
Pompeiano, O., e E. Cotti: Analisi Microelectrodica delle proiezioni cerebello-deitersiane. Arch. Sci. biol. (Bologna) 43, 57–101 (1959); quoted from Brodal et al. (1962).
Precht, W., and H. Shimazu: Functional connections of tonic and kinetic vestibular neurones with primary vestibular afferents. J. Neurophysiol. 28, 1014–1028 (1965).
Rall, W.: Distinguishing theoretical synaptic potentials computed for different soma-dendritic distributions of synaptic input. J. Neurophysiol. 30, 1138–1168 (1967).
—, R.E. Burke, T.G. Smith, P.G. Nelson and K. Frank: Dendritic location of synapses and possible mechanisms for the monosynaptic EPSP in motoneurones. J. Neurophysiol. 30, 1169–1193 (1967).
Sato, M.: Pseudoreflex from end plate and sensory nerve ending. J. Neurophysiol. 16, 101–115 (1953).
Shimazu, H., and W. Precht: Inhibition of central vestibular neurones from the contralateral labyrinth and its mediating pathway. J. Neurophysiol. 29, 467–492 (1966).
Walberg, F., D. Bowsher and A. Brodal: The termination of primary vestibular fibres in the vestibular nuclei in the cat. An experimental study with silver methods. J. comp. Neurol. 110, 391–419 (1958).
Wilson, V.J., M. Kato, B.W. Peterson and R.M. Wylie: A single-unit analysis of the organization of Deiters' nucleus. J. Neurophysiol. 30, 603–619 (1967).
—, R.M. Wylie and L.A. Marco: Synaptic inputs to cells in the medial vestibular nucleus. J. Neurophysiol. 31, 176–185 (1968).
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Ito, M., Hongo, T. & Okada, Y. Vestibular-evoked postsynaptic potentials in Deiters neurones. Exp Brain Res 7, 214–230 (1969). https://doi.org/10.1007/BF00239030
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DOI: https://doi.org/10.1007/BF00239030