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The effect of streptomycin and hypotonicity on survival of Pseudomonas aeruginosa

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Summary

P. aeruginosa proliferates well in a water environment; however, when subjected to high doses of streptomycin or gentamicin, the residual viable bacteria are killed by moderate water dilution of their media. These results lead to the suggestion that the mechanism of lethal action of aminoglycosides may operate through interference with the water balance system of the P. aeruginosa.

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Authors and Affiliations

  1. Cincinnati Unit, Shriners Burns Institute, 202 Goodman Street, 45219, Cincinnati, Ohio, USA

    Paul Nathan

  2. Department of Physiology, University of Cincinnati College of Medicine, 45219, Cincinnati, Ohio, USA

    Ronald T. Plessinger

  3. Department of Surgery, University of Cincinnati College of Medicine, 45219, Cincinnati, Ohio, USA

    Ronald T. Plessinger

Authors
  1. Paul Nathan
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  2. Ronald T. Plessinger
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Nathan, P., Plessinger, R.T. The effect of streptomycin and hypotonicity on survival of Pseudomonas aeruginosa . Appl Microbiol Biotechnol 21, 129–131 (1985). https://doi.org/10.1007/BF00252375

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  • DOI: https://doi.org/10.1007/BF00252375

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