Summary
Glucagon (0.1 mg · 100 g body wt-1) increased norepinephrine (NE) content in adult pigeon (31%) and parakeet (58%), decreased NE content in the adrenal medulla of newly-hatched pigeon (36%), parakeet (52%), and crow (44%) 0.5 h after treatment. Epinephrine (E) content decreased to 26% and 59% of control values, respectively, in newly-hatched pigeon and parakeet 0.5 h after treatment. Glucagon produced hyperglycemia irrespective of age and species. The results indicate that aging modulates glucagon-induced changes of catecholamine (CA) content. In the innervated (I) adrenal gland of pigeon, glucagon caused a 31% increase of NE content 0.5 h after injection, a 46% decrease of NE content 12 h after injection, and a 192% increase of NE 24 h after injection. In the I gland of pigeons, glucagon also caused a 61% decrease of E content 4 h after injection, and brought about a 100% increase of E 24 h after injection. Glucagon-induced changes of CA content differ significantly between the I and denervated (D) glands. The results indicate that the splanchnic nerve regulates release and/or resynthesis of CA induced by glucagon.
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Abbreviations
- ANOVA :
-
analysis of variance
- CA :
-
catecholamine
- D :
-
denervated
- E :
-
epinephrine
- I :
-
innervated
- MS :
-
mean sum of squares
- NE :
-
norepinephrine
- PNMT :
-
phenylethanolamine-N-methyl transferase
- SS :
-
sum of squares
- SV :
-
source of variation
- TH :
-
tyrosine hydroxylase
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Mahata, S.K., Ghosh, A. Influence of age and splanchnic nerve on glucagon-induced changes of adrenomedullary catecholamine content and blood glucose level in the avian group. J Comp Physiol B 161, 532–536 (1991). https://doi.org/10.1007/BF00257909
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DOI: https://doi.org/10.1007/BF00257909