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Treatment of insomnia with two benzodiazepines: a double-blind crossover study

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Summary

Twenty-eight patients (12M, 16F) with insomnia were treated with nitrazepam 5 mg/d and oxazepam 25 mg/d, each for 11 days, in a double-blind crossover comparison with placebo. Half the patients received nitrazepam in the first drug period, and oxazepam in the second and the other half followed the contrary sequence.

Both nitrazepam and oxazepam were found to be effective in inducing sleep and increasing sleep quality. No effects on dreaming or adverse effects were found. Nitrazepam did influence the frequency of awakening, but only in the second drug period. In the first period it reduced self-waking.

It is concluded that both nitrazepam and oxazepam were effective in inducing sleep and in improving sleep quality.

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References

  1. Bixler EO, Kales A, Soldatos CR, Kales JD, Healy B (1979) Prevalence of sleep disorders in the Los Angles metropolitan area. Am J Psychiat 136: 1257–1262

    CAS  PubMed  Google Scholar 

  2. Karacan I, Thornby JI, Anch AM (1979) Prevalence of sleep disturbances in a primarily urban Florida county. Soc Sci Med 10: 239–244

    Google Scholar 

  3. Mellinger GD, Balter MB, Uhlenhuth EH (1985) Insomnia and its treatment: Prevalence and correlates. Arch Gen Psychiat 42: 225–232

    CAS  PubMed  Google Scholar 

  4. Kales A, Kales JD (1984) Evaluation and Treatment of Insomnia. Oxford University Press, New York

    Google Scholar 

  5. Nicholson AN (1986) Hypnotics. Their place in therapeutics. Drugs 31: 164–176

    Google Scholar 

  6. Feinberg I, Fein G, Walker J (1977) Flurazepam effects on slow-wave sleep: Stage 4 suppressed but number of delta waves constant. Science 198: 847–848

    Google Scholar 

  7. Roehrs T, Zorick F, Kaffeman M, Sickelsteel J, Roth T (1982) Flurazepam for short-term treatment of complaint of insomnia. J Clin Pharmacol 22: 290–296

    Google Scholar 

  8. Lehmann W (1978) The effect of oxazepam on sleep in normal human volunteers. Acta Psychiat Scand [Suppl] 274: 33–39

    Google Scholar 

  9. Freemon FR, Al-Marashi MSH, Lee JCM (1977) The effect of a new bezodiazepine on the polygraphically monitored sleep of normal volunteers. J Clin Pharmacol 17: 398–401

    Google Scholar 

  10. Moric CM, Kwentus JA (1988) Area review: Sleep disorders. Behavioral and pharmacological treatments for insomnia. Ann Behav Med 10: 91–100

    Google Scholar 

  11. Kales A, Bixler EO, Kales JD, Scharf MB (1977) Comparative effectiveness of nine hypnotic drugs: Sleep laboratory studies. J Clin Pharmacol 17: 207–213

    Google Scholar 

  12. Wheatley D (1988) New hypnotic agents: Clinical studies in general practice. Pharm Biochem Behav 29: 811–813

    Google Scholar 

  13. Rickels K (1984) Clinical trials of hypnotics. J Clin Psychopharmacol 3: 133–139

    Google Scholar 

  14. Food and Drug Administration, US Department of Health (1977) Guidelines for the clinical evaluation of hypnotic drugs

  15. Kirk RE (1968) Experimental design: procedures for the behavioral sciences. Belmont CA. Brooks/Cole.

    Google Scholar 

  16. Allen RP, Mendels J, Nevins DB, Chernik DA, Hoddes E (1987) Efficacy without tolerance or rebound insomnia for midazolam and temazepam after use for one to three months. J Clin Pharmacol 17: 768–775

    Google Scholar 

  17. Altamura AC, Colacurcio F, Mauri MC, De Vanna M, Rigamonti R, Maj M, Veltro F (1989) Studio clinico controllato dell'effeto del quazepam vs. triazolam in pazienti con disturbi del sonno. Minerva Psichiat 30: 159–164

    Google Scholar 

  18. Hezelbach-Feller DAC, Tshopp JM, Christeller S, Fabre J (1988) Comparison of the short-acting benzodiazepines midazolam and triaozolam with placebo. Arzneim-Forsch/Drug Res 38: 387–392

    Google Scholar 

  19. Ankier ST, Goa KL (1988) Quazepam. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in insomnia. Drugs 35: 42–62

    Google Scholar 

  20. Tham TCK, Brown H, Taggart H McA (1989) Temazepam withdrawal in elderly hospitalized patients: A double blind randomized trial comparing abrupt versus gradual withdrawal. In J Med Sci 158: 295–296

    Google Scholar 

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Authors and Affiliations

  1. Department of Psychiatry and Behavioural Medicine, Östmarka Hospital, University of Trondheim, Trondheim, Norway

    K. G. Götestam, F. Oppöyen & D. Berntzen

Authors
  1. K. G. Götestam
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  2. F. Oppöyen
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  3. D. Berntzen
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Additional information

This study was in part supported by NATO (project no. RG. 0029/88)

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Götestam, K.G., Oppöyen, F. & Berntzen, D. Treatment of insomnia with two benzodiazepines: a double-blind crossover study. Eur J Clin Pharmacol 41, 137–140 (1991). https://doi.org/10.1007/BF00265906

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  • DOI: https://doi.org/10.1007/BF00265906

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