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Commitment to meiosis in fission yeast

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Summary

Mutants of Schizosaccharomyces pombe blocked during meiosis were analysed with respect to the induction of diploid mitotic division. Wild type zygotes of this yeast can form diploid colonies with a low probability (ca. 1%) when they are transferred to fresh growth medium. Mutants of three genes affecting meiosis responded to the shift by forming diploid colonies with high yield (ca. 80% of the zygotes). Hence, commitment to meiosis could not be reached by such zygotes. Zygotes of a fourth meiosis-I-deficient mutant were unable to yield diploid colonies more effectively than wild type zygotes. Morphological changes were prominent in the mutant zygotes not reaching commitment (as well as in mutant cells that could not complete conjugation), indicating that activities needed during early stages of conjugation were not turned off in these zygotes.

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Authors and Affiliations

  1. Institut für Biologie III der Universität Freiburg i. Br., Freiburg i. Br., Germany

    Richard Egel

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  1. Richard Egel
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Additional information

Communicated by F. Kaudewitz

This work was supported by NIH grant GM 13234 initially, and by DFG (SFB 46).

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Egel, R. Commitment to meiosis in fission yeast. Molec. Gen. Genet. 121, 277–284 (1973). https://doi.org/10.1007/BF00267055

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  • DOI: https://doi.org/10.1007/BF00267055

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