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Location of DNA methylation genes on the Escherichia coli K-12 genetic map

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Summary

The genes responsible for DNA adenine methylation (dam) and DNA cytosine methylation (dcm) have been mapped on the E. coli K-12 genetic map. The dam gene is situated at min 65 and the gene order cysG-(trpS, dam)-aro B inferred. The dcm gene is located at min 37.5 and the gene order is supD-dcm-flaA1. In F′ merodiploids, the dam and dcm alleles are recessive.

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References

  • Adelberg, E. A., Burns, S.: Genetic variation in the sex factor of Escherichia coli. J. Bact. 79, 321 (1960)

    Google Scholar 

  • Armstrong, J. B., Adler, J.: Location of genes for motility and chemotaxis on the Escherichia coli genetic map. J. Bact. 97, 156 (1969)

    Google Scholar 

  • Boyer, H. W.: DNA restriction and modification mechanisms in bacteria. Ann. Rev. Microbiol. 25, 153 (1971)

    Google Scholar 

  • Davis, B. D., Mingioli, E. S.: Mutants of Escherichia coli requiring methionine or vitamin B12. J. Bact. 60, 17 (1951)

    Google Scholar 

  • Falaschi, A., Kornberg, A.: A lipopolysaccharide inhibitor of a DNA methyl transferase. Proc. nat. Acad. Sci. (Wash.) 54, 1713 (1965)

    Google Scholar 

  • Guerola, N., Ingraham, J. L., Cerda-Olmedo, E.: Induction of mutations by nitrosoguanidine. Nature (Lond.) New Biol. 230, 122 (1971)

    Google Scholar 

  • Hall, R. H.: The modified nucleosides in nucleic acids. New York and London: Columbia University Press 1971

    Google Scholar 

  • Hattman, S., Gold, E., Plotnik, A.: Methylation of cytosine residues in DNA controlled by a drug resistance factor. Proc. nat. Acad. Sci. (Wash.) 69, 187, (1972)

    Google Scholar 

  • Ikeda, H., Tomizawa, J.: Transducing fragments in generalized transduction by phage Pl. I. Molecular origin of the fragments. J. molec. Biol. 15, 85 (1965)

    Google Scholar 

  • Mamelak, L., Boyer, H. W.: Genetic control of the secondary modification of DNA in Escherichia coli. J. Bact. 104, 57 (1970)

    Google Scholar 

  • Marinus, M. G., Morris, N. R.: Isolation of DNA methylase mutants from Escherichia coli K-12. J. Bact. 114, 1143 (1973)

    Google Scholar 

  • Marmur, J.: A procedure for the isolation of deoxyribonucleic acid from micro-organisms J. molec. Biol. 3, 208 (1961)

    Google Scholar 

  • Messelson, M., Yuan, R., Haywood, J.: Restriction and modification of DNA. Ann. Rev. Biochem. 41, 447 (1972)

    Google Scholar 

  • Smith, J. D., Arber, W., Kuhnlein, U.: Host specificity of DNA produced by Escherichia coli. XIV. The implication of nucleotide methylation in in vivo B-specific modification. J. molec. Biol. 63, 1 (1972)

    Google Scholar 

  • Taylor, A. L., Trotter, C. D.: Linkage map of Escherichia coli strain K-12. Bact. Rev. 36, 504 (1972)

    Google Scholar 

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Communicated by W. Maas

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Marinus, M.G. Location of DNA methylation genes on the Escherichia coli K-12 genetic map. Molec. Gen. Genet. 127, 47–55 (1973). https://doi.org/10.1007/BF00267782

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