Summary
A mutation, previously designated lex-113 and suspected to be situated in the lexA locus, has been positioned by transductional studies to a unique site on the chromosome of E. coli B separate from the lexA102 and uvrA155 mutations. The order of genes in this chromosomal region was demonstrated to be malB-lexA-uvr A-lex-113. The allele designation lexC-113 is suggested for this mutation in a new gene functional in the regulation of inducible lex + - and rec + — dependent SOS activities.
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Bachmann, B.J., Low, K.B., Taylor, A.L.: Recalibrated linkage map of Escherichia coli K-12. Bact. Rev. 40, 116–167 (1976)
Castellazzi, M., George, J., Buttin, G.: Prophage induction and cell division in E. coli. II. Linked (recA zab) and unlinked (lex) suppressors of tif-1 mediated induction and filamentation. Molec. gen. Genet. 119, 153–174 (1972)
Donch, J., Greenberg, J.: Interaction of the exrA mutation with rec mutants of Escherichia coli K 12. Mutation Res. 25, 263–271 (1974)
Donch, J., Greenberg, J.: The effect of lex on UV sensitivity, filament formation and λ induction in lon mutants of Escherichia coli. Molec. gen. Genet. 128, 277–281 (1974)
Donch, J., Greenberg, J.: Sensitivity to elevated temperatures in exrB strains of Escherichia coli. Mutation Res. 25, 403–405 (1974)
Greenberg, J., Berends, L.J., Donch, J., Green, M.H.L.: exrB: a malB-linked gene in Escherichia coli B involved in sensitivity to radiation and filament formation. Genet. Res. (Camb.) 23, 175–184 (1974)
Greenberg, J., Berends, L., Donch, J., Johnson, B.F.: Reversion studies with exrB in Escherichia coli. Genet. Res. (Camb.) 25, 109–117 (1975)
Iyer, V.N., Iyer, R.V., Palchoudhury, S.R., Becker, S., Stevenson, I.: An aspect of the physiology of strains carrying a dnaB mutation. Molec. gen. Genet. 133, 111–122 (1974)
Johnson, B.F.: Fine structure mapping and properties of mutations suppressing the lon mutation in Escherichia coli K-12 and B strains. (Genet. Res., in press)
Mount, D.W.: A mutant of Escherichia coli showing constitutive expression of the lysogenic induction and error-prone DNA repair pathways. Proc. nat. Acad. Sci. (Wash.) 74, 300–304 (1977)
Mount, D.W., Kosel, C.: Properties of strains of Escherichia coli K12 carrying mutant lexA-1 and uvrA6 alleles. Molec. gen. Genet. 120, 291–299 (1973)
Mount, D.W., Kosel, C.: Ultraviolet-induced mutation in UV-resistant, thermosensitive derivatives of lexA strains of E. coli K-12. Molec. gen. Genet. 136, 95–106 (1975)
Mount, D.W., Low, K.B., Edmiston, S.J.: Dominant mutations (lex) in Escherichia coli K-12 which affect radiation sensitivity and frequency of ultraviolet light induced mutations. J. Bact. 112, 950–956 (1972)
Volkert, M.R., George, D.L., Witkin, E.M.: Partial suppression of the LexA phenotype by mutations (rmn) which resotre ultraviolet resistance but not ultraviolet mutability to Escherichia coli B/r uvr A lexA. Mutation Res. 36, 17–28 (1976)
Wechsler, J.A., Gross, J.D.: Escherichia coli mutants temperaturesensitive for DNA synthesis. Molec. gen. Genet. 113, 273–284 (1971)
Witkin, E.M.: Mutation-proof and mutation-prone modes of survival in derivatives of Escherichia coli B differing in sensitivity to ultraviolet light. Brookhaven Symp. Biol. 20, 17–55 (1967)
Wu, T.T.: A model for three-point analysis of random general transduction. Genetics 54, 405–410 (1966)
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Communicated by E. Witkin
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Johnson, B.F. Genetic mapping of the lexC-113 mutation. Molec. Gen. Genet. 157, 91–97 (1977). https://doi.org/10.1007/BF00268691
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DOI: https://doi.org/10.1007/BF00268691