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Pleiotropic mutants affecting the control of nitrogen metabolism in Aspergillus nidulans

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Summary

Mutants of Aspergillus nidulans with lesions in gene amdT are pleiotropically affected in their ability to utilize a wide variety of nitrogen sources in the presence of glucose. Ability to utilize a number of these compounds as sole sources of carbon and nitrogen is not altered. One of these mutants, amdT102, has properties consistent with it being derepressed for glucose repression of the utilization of most (but not all) nitrogen sources. The amdT102 mutant can grow strongly on histidine, lysine and cystine as sole nitrogen sources while the wild type strain grows extremely poorly on these amino acids. Similar but less extreme effects apply to many other nitrogen sources. The amdT19 mutant is unable to utilize most nitrogen sources in the presence of glucose, suggesting that it is subject to greatly increased repression of nitrogen source utilization. The amdT mutants are not affected in their ability to use many compounds as sole carbon sources. Carbon sources other than glucose also affect utilization of nitrogen sources in the amdT mutants.

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Authors and Affiliations

  1. Department of Genetics, La Trobe University, Bundoora, Victoria, Australia

    M. J. Hynes

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  1. M. J. Hynes
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Communicated by W. Gajewski

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Hynes, M.J. Pleiotropic mutants affecting the control of nitrogen metabolism in Aspergillus nidulans . Molec. Gen. Genet. 125, 99–107 (1973). https://doi.org/10.1007/BF00268862

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  • DOI: https://doi.org/10.1007/BF00268862

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