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The influence of inactive chromosomes on human development

Anomalous sex chromosome complements and the phenotype

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Summary

The effects of supernumerary X and Y chromosomes on various traits that can be quantitatively measured are summarised: these traits include dermatoglyphics, intelligence, birthweight, height and immunoglobulin levels. Evidence that heterochromatic X and Y chromosomes can slow down the mitotic cycle of cells in culture is presented. It is proposed that some of the effects extra X and Y chromosome have on the phenotype may be related to a reduced rate of cell division during development.

Zusammenjassung

Die Wirkung überzähliger X- und Y-Chromosomen auf quantitativ meßbare Merkmale (Hautleisten, Intelligenz, Geburtsgewicht, Körpergröße und Immunglobulinspiegel) wird beschrieben. Andere Untersuchungen deuten darauf hin, daß heterochromatische X- und Y-Chromosomen evtl. den Mitosecyclus in der Zellkulture verlangsamen. Es wird vermutet, daß einige phänotypische Wirkungen überzähliger X- und Y-Chromosomen durch verminderte Zellteilung in der Individual-Entwicklung bedingt sein könnten.

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  1. Paediatric Research Unit, Guy's Hospital Medical School, S.E.1, London, England

    Peter Barlow

  2. Unit of Developmental Botany, University of Cambridge, Cambridge, England

    Peter Barlow

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Barlow, P. The influence of inactive chromosomes on human development. Hum Genet 17, 105–136 (1973). https://doi.org/10.1007/BF00277906

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