Summary
Whilst studying the chromosomes of the peripheral blood lymphocytes of normal controls and patients with lymphoproliferative disorders, two examples of preferential breakage of a sensitive chromosomal region were found. A patient with lymphocytic lymphoma had a sensitive region in a C9 chromosome coinciding with the secondary constriction. A healthy woman had one A2 chromosome showing an unusually located secondary constriction in which breakage sometimes occurred.
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Reeves, B.R., Lawler, S.D. Preferential breakage of sensitive regions of human chromosomes. Hum Genet 8, 295–301 (1970). https://doi.org/10.1007/BF00280327
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DOI: https://doi.org/10.1007/BF00280327