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Preparation and biocompatibility of novel polar-nonpolar networks

I. Synthesis, characterization and histological-bacterial analysis of mixed polytetrahydrofuran-polyisobutylene networks

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Abstract

Mixed polar-nonpolar urethane networks have been prepared by crosslinking various mixtures of polyisobutylene diols (HO-PIB-OH) and polar polytetrahydrofuran diols (HO-PTHF-OH) with stoichiometric quantities of a triisocyanate. Essentially complete crosslinking was demonstrated by very low (<4%) sol fractions in benzene and THF. The mixed networks were biocompatible and had less tissue response than pure PIB as evaluated by bacterial and histological analysis after 11 weeks of implantation at the following sites: dorsal neck muscle, abdominal cavity and near the abdominal aorta.

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Authors and Affiliations

  1. Institute of Polymer Science, University of Akron, 44325, Akron, OH, USA

    A. Gadkari & J. P. Kennedy

  2. Department of Biology, University of Akron, 44325, Akron, OH, USA

    M. M. Kory & D. L. Ely

Authors
  1. A. Gadkari
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  2. J. P. Kennedy
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  3. M. M. Kory
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  4. D. L. Ely
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Gadkari, A., Kennedy, J.P., Kory, M.M. et al. Preparation and biocompatibility of novel polar-nonpolar networks. Polymer Bulletin 22, 25–32 (1989). https://doi.org/10.1007/BF00283280

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  • DOI: https://doi.org/10.1007/BF00283280

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