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Nucleolus organizer regions and nucleoli

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References

  • Bennet MD (1982) The nucleotypic basis of the spatial ordering of chromosomes in eukaryotes and the implications of the order for genome evolution and phenotypic variation. In: Dover GA, Flavell RB (eds) Genome evolution. Academic Press, New York London, pp 239–261

    Google Scholar 

  • Bird A, Taggart M, Macleod D (1981) Loss of rDNA methylation accompanies the onset of ribosomal gene activity in early development of X. laevis. Cell 26:381–390

    Google Scholar 

  • Bourgeois CA, Hernandez-Verdun D, Hubert J, Bouteille M (1979) Silver staining of NORs in electron microscopy. Exp Cell Res 123:449–452

    Google Scholar 

  • Bouteille M, Dupuy-Coin AM (1979) Localization of nucleolar functions at the cellular and molecular level. In: Busch H, Crooke ST, Daskal Y (eds) Effcets of drugs on the cell nucleus Academic Press, New York London, pp 1–33

    Google Scholar 

  • Bouteille M, Hernandez-Verdun D, Dupuy-Coin AM (1982) Nucleoli and nucleolar-related structures in normal, infected and drug treated cells. In: Jordan EG, Cullis CA (eds) The nucleolus. Cambridge University Press, Cambridge, pp 179–211

    Google Scholar 

  • Bouteille M, Laval M, Dupuy-Coin AM (1974) Localization of nuclear functions as revealed by ultrastructural autoradiography and cytochemistry. In: Busch H (ed) The cell nucleus. Academic Press, New York London, pp 5–64

    Google Scholar 

  • Bross K, Krone W (1972) On the number of ribosomal genes in man. Hum Genet 14:137–141

    Google Scholar 

  • Busch H, Lischwe MA, Michalik J, Pui Kwong CH, Busch HK (1982) Nucleolar proteins of special interest: silver staining proteins B23 and C23 and antigens of human tumour nucleoli. In: Jordan EG, Cullis CA (eds) The nucleolus. Cambridge University Press, Cambridge, pp 43–71

    Google Scholar 

  • Busch H, Smetana K (1970) The nucleolus. Academic Press, New York London

    Google Scholar 

  • Buys CHCM, Osinga J (1980) Abundance of protein-bound sulfhydryl and disulfide groups at chromosomal nucleolus organizing regions. Chromosoma 77:1–11

    Google Scholar 

  • Cajal SR (1903) Un sencillo método de coloración del reticulo protoplasmico y sus efectos en los diversos centros nerviosos de vertebrados é invertebrados. Trab Lab Invest Biol Madrid 2:129–221

    Google Scholar 

  • Cajal SR (1910) El nucleo de los celulas piramidales del cerebro humano y de algunos mamiferos. Trab Lab Invest Biol Madrid 8:27–62

    Google Scholar 

  • Capoa A de, Ferraro M, Menendez F, Mostacci C, Pellicia F, Rocchi A (1978) Ag-staining of the nucleolus organizer and its relationship to satellite association. Hum Genet 44:71–77

    Google Scholar 

  • Cooke P, Curtis DJ (1974) General and specific patterns of acrocentric associations in parents of mongol children. Hum Genet 23:279–287

    Google Scholar 

  • Das NK (1962) Demonstration of a non-RNA nucleolar fraction by silver staining. Exp Cell Res 26:428–431

    Google Scholar 

  • Dupuy-Coin AM, Ege T, Bouteille M, Ringertz NR (1976) Ultrastructure of chick erythrocyte nuclei undergoing reactivation in heterokaryons and enucleated cells. Exp Cell Res 101:355–369

    Google Scholar 

  • Ellinger A, Wachtler F (1980) Über eine Methode zur Darstellung des Nucleolus im Licht- und Elektronenmikroskop. Mikroskopie 36:330–335

    Google Scholar 

  • Esponda P, Gimenez-Martin G (1975) Nucleolar organizer ultrastructure in allium cepa. Chromosoma 52:73–78

    Google Scholar 

  • Estable C, Sotelo JR (1950) Una nueva estructura celular: el nucleolonema. Publ Inst Invest Cien Biol Montevideo 1:105–126

    Google Scholar 

  • Evans HJ, Buckland RA, Pardue ML (1974) Location of genes coding for 18S and 28S ribosomal RNA in the human genome. Chromosoma 48:405–426

    Google Scholar 

  • Fakar S, Puvion S (1980) Ultrastructural visualization of nucleolar and extranucleolar RNA-synthesis and distribution. Int Rev Cytol 65:255–299

    Google Scholar 

  • Ferguson-Smith MA (1964) The sites of nucleolus formation in human pachytene chromosomes. Cytogenetics 3:124–134

    Google Scholar 

  • Ferguson-Smith MA, Handmaker SD (1961) Observations on the satellited human chromosomes. Lancet I:638

    Google Scholar 

  • Ferraro M, Archidiacono N, Pellicia F, Rocchi F, Rocchi M, de Capoa A (1977) Secondary constrictions and nucleolus organizer regions in man. Exp Cell Res 104:428–430

    Google Scholar 

  • Ferraro M, Lavia P, Pellicia F, de Capoa A (1981) Clonal inheritance of rRNA gene activity: cytological evidence in human cells. Chromosoma 84:345–351

    Google Scholar 

  • Flavell RB, Martini G (1982) The genetic control of nucleolus formation with special reference to common breadwheat. In: Jordan EG, Cullis CA (eds) The nucleolus. Cambridge University Press, Cambridge, pp 113–128

    Google Scholar 

  • Fontana F (1781) Traité sur le vénin de la vipere, avec des observations sur la structure primitive du corps animale. Florence

  • Funaki K, Matsui S, Sasaki M (1975) Location of nucleolar organizers in animal and plant chromosomes by means of an improved N-banding technique. Chromosoma. 49:357–370

    Google Scholar 

  • Galperin-Lemaitre H, Hens L, Kirsch-Volder M, Susanne C (1977) Non-random association of trypsin-banded human acrocentric chromosomes. Hum Genet 35:261–268

    Google Scholar 

  • Ghosh S (1976) The nucleolar structure. Int Rev Cytol 44:1–28

    Google Scholar 

  • Gimenez-Martin G, de la Torre C, Lopez-Saez JF, Esponda P (1977) Plant nucleolus: structure and physiology. Cytobiologie 14:421–462

    Google Scholar 

  • Goessens G (1976) High resolution autoradiographic studies of Ehrlich tumor cell nucleoli. Nucleolar labelling after 3H-actinomycin D binding to DNA or after 3HTdR or 3H-uridine incorporation in nucleic acids. Exp Cell Res 100:88–94

    Google Scholar 

  • Goessens G (1979a)Relations between fibrillar centers and nucleolus-associated chromatin in Ehrlich tumour cells Cell Biol Int Rep 3: 337–343

    Google Scholar 

  • Goessens G (1979b) Localization of NOR in interphase cells. Cell Tiss Res 200:159–161

    Google Scholar 

  • Goessens G, Lepoint A (1974) The fine structure of the nucleolus during interphase and mitosis in Ehrlich tumour cells cultivated in vitro. Exp Cell Res 87:63–72

    Google Scholar 

  • Goessens G, Lepoint A (1979) The nucleolus-organizing regions (NOR's): Recent data and hypotheses. Biol Cell 35:211–220

    Google Scholar 

  • Goessens G, Lepoint A (1982) Localization of Ag-NOR-proteins in Ehrlich tumour cell nucleoli. Biol Cell 43:139–142

    Google Scholar 

  • Goodpasture C, Bloom SE (1975) Visualization of nucleolar organizer regions in mammalian chromosomes using silver staining. Chromosoma 53:37–50

    Google Scholar 

  • Granboulan N, Granboulan P (1965)Cytochimie ultrastructurale du nucléole. II. Etude des sites de synthèse du RNA dans le nucléole et le noyau. Exp Cell Res 38:604–619

    Google Scholar 

  • Hansson A (1979) Satellite association in human metaphases. Hereditas 90:59–83

    Google Scholar 

  • Hansson A, Mikkelsen M (1974) An increased tendency to satellite association of human chromosome 21: A factor in the aetiology of Down's syndrome. IRCS (Anat Pediatr Psychiat) 2:1617

    Google Scholar 

  • Heitz E (1931) Die Ursache der gesetzmäßigen Zahl, Lage, Form und Größe pflanzlicher Nucleolen. Planta 12:775–884

    Google Scholar 

  • Henderson AS, Warburton D, Atwood KC (1972) Localization of ribosomal DNA in the human chromosome complement. Proc Natl Acad Sci USA 69:3394–3398

    Google Scholar 

  • Henderson LM, Bruere AN (1980) Inheritance of Ag-stainability of the NOR in domestic sheep, Ovis aries. Cytogenet Cell Genet 26:1–6

    Google Scholar 

  • Hernandez-Verdun D, Bouteille M (1979) Nucleologenesis in chick erythrocyte nuclei reactivated by cell fusion. J Ultrastruct Res 69: 164–179

    Google Scholar 

  • Hernandez-Verdun D, Derenzini M, Bouteille M (1982) The morphological relationship in electron-microscopy between NOR-silver proteins and intranucleolar chromatin. Chromosoma 85:461–473

    Google Scholar 

  • Hernandez-Verdun D, Hubert J, Bourgeois CA, Bouteille M (1980) Ultrastructural localization of Ag-NOR stained proteins in the nucleolus during cell cycle and in other nucleolar structures. Chromosoma 79:349–362

    Google Scholar 

  • Hofgärtner FJ, Krone W, Jain K (1979a) Correlated inhibition of rRNA synthesis and silver-staining by actinomycin D. Hum Genet 47:329–333

    Google Scholar 

  • Hofgärtner FJ, Schmid M, Krone W, Zenzes MT, Engel W (1979b) Partern of activity of nucleolus organizers during spermatogenesis in mammals as analysed by silver staining. Chromosoma 71:197–216

    Google Scholar 

  • Howell WM, Denton TE, Diamond JR (1975) Differential staining of the satellite regions of human acrocentric chromosomes. Experientia 31:260–262

    Google Scholar 

  • Hsu TC, Brinkley BR, Arrighi FD (1967) The structure and behavior of the nucleolus organizers in mammalian cells. Chromosoma 23:137–153

    Google Scholar 

  • Hubell HR, Rothblum LI, Hsu TC (1979) Identification of a silver binding protein associated with the cytological silver staining of actively transcribing nucleolar regions. Cell Biol Int Rep 3:615–622

    Google Scholar 

  • Jordan EG, Luck BT (1976) The nucleolus organizer and the synaptonemal complex in Endymian non-scriptus (L). J Cell Sci 22:75–86

    Google Scholar 

  • Jordan EG, McGovern JH (1981) The quantitative relationship of the fibrillar centers and other nucleolar components to changes in growth conditions, serum deprivation and low doses of actinomycin D in cultured diploid human fibroblasts (strain MRC 5). J Cell Sci 52:373–389

    Google Scholar 

  • Knibiehler B, Navarro A, Mirre C, Stahl A (1977) Localization of ribosomal cistrons in the quail oocyte during meiotic prophase I. Exp Cell Res 110:153–157

    Google Scholar 

  • Lache IG (1906) L'aspect du noyau de la cellule nerveuse dans la méthode à l'argent réduit. Anat Anz 28:161–168

    Google Scholar 

  • La Cour LF, Crawley JWC (1965) The site of rapidly labelled ribonucleic acid in nucleoli. Chromosoma 16:124–132

    Google Scholar 

  • Lavelle A, Lavelle FW (1970) Cytodifferentiation in the neuron. In: Himwich WA (ed) Developmental neurobiology. C. Thomas, Springfield Ill

    Google Scholar 

  • Lettré R, Siebs W (1954) Zur Struktur des Nucleolus. Naturwiss 41:458

    Google Scholar 

  • Lew GM, Payer A, Quay WB (1982) The pinealocyte nucleolus. Cell Tiss Res 224:195–206

    Google Scholar 

  • Leydig F (1852) Anatomische Notizen über Synapta digitata. Arch Anat Physiol Wiss Med:507–519

  • Lindahl T (1981) DNA-methylation and control of gene expression. Nature 290:363–364

    Google Scholar 

  • Lischwe MA, Smetana K, Olson MOS, Busch H (1979) Proteins C23 and B23 are the major nucleolar silver staining proteins. Life Sci 25:701–708

    Google Scholar 

  • Long EO, Dawid IB (1980) Repeated genes in eukaryotes. Annu Rev Biochem 49:727–764

    Google Scholar 

  • Love R (1962) Improved staining of the nucleoproteins of the nucleolus. J Histochem Cytochem 10:227

    Google Scholar 

  • Macgregor HC (1982) Ways of amplifying ribosomal genes. In: Jordan EG, Cullis CA (eds) The nucleolus. Cambridge University Press, Cambridge, pp 129–151

    Google Scholar 

  • Marinesco G (1905) Recherches sur le noyau et le nucléole de le cellule nerveuse à l'état normal et pathologique. J Psychol Neurol 5:151–172

    Google Scholar 

  • Matsui S (1974) Structural proteins associated with ribosomal cistrons in Xenopus laevis chromosomes. Exp Cell Res 88:88–94

    Google Scholar 

  • Matsui S, Sasaki M (1973) Differential staining of nucleolus organizers in mammalian chromosomes. Nature 246:148–150

    Google Scholar 

  • McClintock B (1934) The relation of a particular chromosomal element to the development of the nucleoli in Zea mays. Z Zellforsch 21:294–328

    Google Scholar 

  • McKnight SL, Miller OL (1976) Ultrastructural patterns of RNA-synthesis during early embryogenesis of Drosophila melanogaster. Cell 8:305–319

    Google Scholar 

  • Medina FJ, Risueno MC (1981) Nucleolar structure and dynamics during meiotic prophase in pea ovules. Biol Cell 42:79–86

    Google Scholar 

  • Michotte A (1904) Contribution à l'etude de l'histologie fine de la cellule nerveuse. Le névraxe 6:235–278

    Google Scholar 

  • Mikelsaar AV, Ilus T (1979) Population polymorphisms in silver staining of nucleolus organizer regions in human acrocentric chromosomes. Hum Genet 51:281–285

    Google Scholar 

  • Mikelsaar AV, Schmid M, Krone W, Schwarzacher HG, Schnedl W (1977a) Frequency of Ag-stained nucleolus organizer regions in the acrocentric chromosomes of man. Hum Genet 37:73–77

    Google Scholar 

  • Mikelsaar AV, Schwarzacher HG (1978) Comparison of silver staining of nucleolus organizer regions in human lymphocytes and fibroblasts. Hum Genet 42:291–299

    Google Scholar 

  • Mikelsaar AV, Schwarzacher HG, Schnedl W, Wagenbichler P (1977b) Inheritance of Ag-stainability of nucleolus organizer regions. Hum Genet 38:183–188

    Google Scholar 

  • Miller DA, Breg WR, Warburton D, Dev VG, Miller OJ (1978) Regulation of rRNA-gene expression in a human familial 14p+marker chromosome. Hum Genet 43:289–297

    Google Scholar 

  • Miller DA, Dev VG, Tantravahi R, Miller OJ (1976a) Suppression of human nucleolus organizer activity in mouse-human somatic hybrid cells. Exp Cell Res 101:235–243

    Google Scholar 

  • Miller DA, Tantravahi R, Dev VG, Miller OJ (1977) Frequency of satellite association of human chromosomes is correlated with amount of Ag-staining of the nucleolus organizer region. Am J Hum Genet 29:490–502

    Google Scholar 

  • Miller OJ, Miller DA, Dev VG, Tantravahi R, Croce CM (1976b) Expression of human and suppression of mouse nucleolus activity in mouse-human somatic cell hybrids. Proc Natl Acad Sci USA 73:4531–4535

    Google Scholar 

  • Miller OJ, Tantravahi U, Katz R, Erlanger BF, Guntaka RV (1981) Amplification of mammalian ribosomal RNA genes and their regulation by methylation. In: Arrighi FE, Rao PN, Stubblefield E (eds) Genes, chromosomes and neoplasia. Raven Press, New York

    Google Scholar 

  • Miller OJ, Tantravahi U, Miller DA, Yu LC, Szabo P, Prensky W (1979) Marked increase in ribosomal RNA gene multiplicity in a rat hepatoma cell line. Chromosoma 71:183–195

    Google Scholar 

  • Miller OL (1981) The nucleolus, chromosomes and visualization of genetic activity. J Cell Biol 91:15s-27s

    Google Scholar 

  • Mirre C, Knibiehler B (1981) Ultrastructural autoradiographic localization of the rRNA-transcription sites in the quail nucleolar components using two RNA-antimetabolites. Biol Cell 42:73–78

    Google Scholar 

  • Mirre C, Knibiehler B (1982) A reevaluation of the relationships between the fibrillar centers and the nucleolus organizing regions in reticulated nucleoli: Ultrastructural organization, number and distribution of the fibrillar centers in the nucleolus of the mouse Sertoli cell. J Cell Sci 55:247–259

    Google Scholar 

  • Mirre C, Stahl A (1978a) Peripheral RNA-synthesis of fibrillar center in nucleoli of Japanese quail oocytes and somatic cells. J Ultrastruct Res 64:377–378

    Google Scholar 

  • Mirre C, Stahl A (1978b) Ultrastructure and activity of the nucleolar organizer in the mouse oocyte during meiotic prophase. J Cell Sci 31:79–100

    Google Scholar 

  • Mirre C, Stahl A (1981) Ultrastructural organization, sites of transcription and distribution of fibrillar centers in the nucleolus of the mouse oocyte. J Cell Sci 48:105–126

    Google Scholar 

  • Montgomery TH (1899) Comparative cytological studies with especial regard to the morphology of the nucleolus. J Morphol 15:265–583

    Google Scholar 

  • Moss T, Birnstiel M (1982) The structure and function of the ribosomal gene spacer. In: Jordan EG, Cullis CA (eds) The nucleolus. Cambridge University Press, Cambridge, pp 73–85

    Google Scholar 

  • Noel JS, Dewey WC, Abel JH, Thompson RP (1971) Ultrastructure of the nucleolus during Chinese hamster cell cycle. J Cell Biol 49:830–847

    Google Scholar 

  • Olert J, Sawatzki G, Kling H, Gebauer J (1979) Cytological and histochemical studies on the mechanism of selective silver staining of nucleolus organizer regions (NORs). Histochemistry 60:91–99

    Google Scholar 

  • Paweletz N, Risueno MC (1982) Transmission electron microscopic studies on the mitotic cycle of nucleolar proteins impregnated with silver. Chromosoma 85:261–273

    Google Scholar 

  • Pebusque MJ, Vio M, Seite R (1981) Ultrastructural location of Ag NOR stained proteins in nucleoli of rat sympathetic neurons during the dark period. Biol Cell 40:151–154

    Google Scholar 

  • Perry RP (1981) RNA-processing comes of age. J Cell Biol 91:28s-38s

    Google Scholar 

  • Pössnerova V, Smetana K (1966) The morphology of lymphocytes in peripheral human blood after short term cultivation in vitro. Folia Morphol (Praha) 14:240–244

    Google Scholar 

  • Quatrefage A de (1849) Etudes embryogéniques. Mémoire sur l'embryogénie des tarets. Ann Sci Nat Ser 3:11

    Google Scholar 

  • Razin A, Riggs AD (1980) DNA-methylation and gene function. Science 210:604–610

    Google Scholar 

  • Recher L, Whitescarver J, Briggs L (1969) Fine structure of a nucleolar constituent. J Ultrastruct Res 29:1–14

    Google Scholar 

  • Reeves BR, Casey G, Harris H (1980) Variations in the activity of nucleolar organizers in different tissues. 7th Internat Chromos Conf, Oxford

  • Rosenkranz W, Fleck S (1969) Die Bedeutung der Assoziation satellitentragender Chromosomen. Hum Genet 7:9–21

    Google Scholar 

  • Royal A, Simard R (1975) RNA-synthesis in the ultrastructural and biochemical components of the nucleolus of Chinese hamster ovary cells. J Cell Biol 66:577–585

    Google Scholar 

  • Ruzicka V (1899) Zur Geschichte und Kenntnis der feineren Structur der Nucleolen centraler Nervenzellen. Anat Anz 16:557–563

    Google Scholar 

  • Salzman NP, Pellegrino M, Franceschini P (1966) Biochemical changes in PHA-stimulated lymphocytes. Exp Cell Res 44:73–83

    Google Scholar 

  • Scheer U, Kleinschmidt JA, Franke WW (1982) Transcriptional and skeletal elements in nucleoli of amphibian oocytes. In: Jordan EG, Cullis CA (eds) The nucleolus. Cambridge University Press, Cambridge, pp 25–42

    Google Scholar 

  • Schleiden MJ (1838) Beiträge zur Phytogenesis. Arch Anat Physiol Wiss Med, pp 137–176

  • Schmiady H, Münke M, Sperling K (1979) Ag-staining of NOR regions in human prematurely condensed chromosomes from cells with different ribosomal RNA gene activity. Exp Cell Res 121:425–428

    Google Scholar 

  • Schmid M, Krone W, Vogel W (1974) On the relationship between the frequency of association and the nucleolar constriction of individual acrocentric chromosomes. Hum Genet 23:267–277

    Google Scholar 

  • Schwann T (1839) Mikroskopische Untersuchungen über die Übereinstimmung in der Struktur und dem Wachstum der Thiere und Pflanzen. Berlin

  • Schwarzacher HG (1976) Chromosomes in mitosis and interphase. In: Bargmann W (ed) Handbuch der mikroskopischen Anatomie des Menschen I/3. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Schwarzacher HG, Mikelsaar AV, Schnedl W (1978) The nature of Ag-staining of nucleolus organizer regions. Cytogenet Cell Genet 20:24–39

    Google Scholar 

  • Seite R, Pebusque JM, Robaglia A (1980) Stereological analysis of circadian rhythm of nucleolar fibrillar centers in neurons of the rat superior cervical ganglion. Eur J Cell Biol 22:499

    Google Scholar 

  • Sigmund J, Schwarzacher HG, Mikelsaar AV (1979) Satellite association frequency and number of nucleoli depend on cell cycle duration and NOR activity. Hum Genet 50:81–91

    Google Scholar 

  • Smetana K, Busch H (1974) The nucleolus and nucleolar DNA. In: Busch H (ed) The cell nucleus 1. Academic Press, New York London

    Google Scholar 

  • Smetana K, Gyorkey F, Gyorkey P, Busch H (1975) Studies on nucleoli of maturing human erythroblasts. Exp Cell Res 91:143–151

    Google Scholar 

  • Smetana K, Lejnar J, Potmesil M (1969) A further contribution on the incidence of ring-shaped nucleoli and micronucleoli of blood cells in smear preparations. Folia Haematol (Leipz) 91:381–394

    Google Scholar 

  • Smetana K, Likovsky Z (1976) Micronucleoli in mouse erythroblasts. J Micr Biol Cell 25:39–42

    Google Scholar 

  • Stahl A (1982) The nucleolus and nucleolar chromosomes. In: Jordan EG, Cullis CA (eds) The nucleolus. Cambridge University Press, Cambridge, pp 1–24

    Google Scholar 

  • Tandler CJ (1959) The silver reducing property of the nucleolus and the formation of prenucleolar material during mitoses. Exp Cell Res 17:560–564

    Google Scholar 

  • Tantravahi R, Miller DA, D'Ancona G, Croce CM, Miller OJ (1979) Location of rRNA genes in inbred strains of rat and suppression of rat rRNA activity in rat-human somatic cell hybrids. Exp Cell Res 119:387–392

    Google Scholar 

  • Taylor EF, Martin-De Leon PA (1981) Familial silver staining patterns of human nucleolus organizer regions (NOR). Am J Hum Genet 33:67–76

    Google Scholar 

  • Taysi K (1975) Satellite association: Giemsa banding studies in parents of Down's syndrome patients. Clin Genet 8:319–323

    Google Scholar 

  • Todorov IT, Hadjiolov AA (1979) A comparison of nuclear and nucleolar matrix proteins from rat liver. Cell Biol Int Rep 3:753–757

    Google Scholar 

  • Torre C de la, Gimenez-Martin G (1982) The nucleolar cycle. In: Jordan EG, Cullis CA (eds) The nucleolus. Cambridge University Press, Cambridge, pp 153–177

    Google Scholar 

  • Valentin GG (1836) Repertorium für Antomie und Physiologie, I. Berlin

  • Varley JM (1977) Patterns of silver staining of human chromosomes. Chromosoma 61:207–214

    Google Scholar 

  • Wachtler F (1982) On the identification of active nucleolus organizing regions (NOR) in interphase. Postery Biologii Komorki 9:233–239

    Google Scholar 

  • Wachtler F, Ellinger A, Schwarzacher HG (1980) Nucleolar changes in human PHA-stimulated lymphocytes. Cell Tiss Res 213:351–360

    Google Scholar 

  • Wachtler F, Musil R (1979) Nucleoli visualized by silver-staining combined with a new, RNA specific fluorochrome. Stain Technol 54:265–268

    Google Scholar 

  • Wachtler F, Schwarzacher HG, Ellinger A (1981) Zur Morphologie des Nucleolus bei Aktivierung und Inaktivierung von Zellen: Untersuchungen an menschlichen Lymphozyten in vitro. Acta Anat (Basel) 111:158

    Google Scholar 

  • Wachtler F, Schwarzacher HG, Ellinger A (1982) The influence of the cell cycle on the structure and number of nucleoli in cultured human lymphocytes. Cell Tiss Res 225:155–163

    Google Scholar 

  • Warburton D, Atwood RC, Henderson AS (1976) Variation in the number of genes for rRNA among human acrocentric chromosomes: correlation with frequency of satellite association. Cytogenet Cell Genet 17:221–230

    Google Scholar 

  • Warburton D, Henderson AS (1979) Sequential silver staining and hybridization in situ on nucleolus organizing regions in human cells. Cytogenet Cell Genet 24:168–175

    Google Scholar 

  • Warner JR (1979) Distribution of newly formed ribosomal proteins in Hela cell fractions. J Cell Biol 80:767–772

    Google Scholar 

  • Williams WA, Kleinschmidt JA, Krohne G, Franke WW (1982) Argyrophilic nuclear and nucleolar proteins of Xenopus laevis oocytes identified by gel electrophoresis. Exp Cell Res 137:341–351

    Google Scholar 

  • Wollenberg C, Kiefaber MP, Zang KD (1982) Quantitative studies on the arrangement of human metaphase chromosomes. VIII. Localization of homologous chromosomes. Hum Genet 60:239–248

    Google Scholar 

  • Zakharov AF, Davudov AV, Benjush VA, Egolina NA (1982) Polymorphism of Ag-stained nucleolar organizer regions in man. Hum Genet 60:334–339

    Google Scholar 

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Schwarzacher, H.G., Wachtler, F. Nucleolus organizer regions and nucleoli. Hum Genet 63, 89–99 (1983). https://doi.org/10.1007/BF00291525

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