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Study of Mitomycin C-induced chromosomal exchange

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Abstract

Mitomycin C-induced sister chromatic exchange and quadriradial formation were studied in chromosomes from Muntiacus muntjac fibroblasts and A9, a transformed mouse cell line. We present the first direct cytological evidence for the induction of true somatic recombination involving homologous chromosomes. Analysis of the quadriradials from Muntjac cells indicates a non-random distribution with respect to the chromosomes involved and with respect to the points of conjunction. Sister chromatid exchange and quadriradial formation may reflect the outcome of repair processes involving a high frequency of homologous exchanges in the interphase nucleus.

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Authors and Affiliations

  1. Department of Biology, Yale University, 06520, New Haven, Connecticut, USA

    Kenneth M. Huttner & Frank H. Ruddle

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  1. Kenneth M. Huttner
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  2. Frank H. Ruddle
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Huttner, K.M., Ruddle, F.H. Study of Mitomycin C-induced chromosomal exchange. Chromosoma 56, 1–13 (1976). https://doi.org/10.1007/BF00293724

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  • DOI: https://doi.org/10.1007/BF00293724

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