Summary
363 samples of different tissues were taken for cultivation from 118 antepartum deaths, 85 intrapartum deaths and 112 newborn dying during the first days after delivery. Successful growth of culture was noticed in 48.2% (15.4%) of antepartum deaths; 71.8% of intrapartum deaths and 68.1% of newborn dying during the first days of life. Among the 22 antepartum deaths 3 (13.6%) infants were found to have anomalies of karyotype; among 61 intrapartum deaths 3 (4.9%) infants were found to have karyotype anomalies; and among 92 early neonatal deaths 6 ones (6.5%) had karyotype anomalies. The total frequency of chromosome anomalies among the infants dying during the perinatal period was 6.9%.
The final result of cytogenetic investigation of 607 premature infants was that chromosome anomalies were found among 2.5%, that is 3.5 times as much, as in the general newborn population. Among the types of chromosome anomalies the main defects were anomalies in the system of sex chromosomes and trisomy-21, and that is the proof of the fact, that other types of anomalies, found in newborn populations lead to earlier lethality.
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References
Arakaki, D. T., Waxman, S. H.: Chromosome abnormalities in early spontaneous abortion. J. med. Genet. 7, 118 (1970)
Bochkov, N. P., Antoschina, M. M., Stonova, N. S.: Abnormalities in sex chromosomes in still-borns and dead children. Cytologia (USSR) 8, 215 (1966)
Bochkov, N. P., Kuleshov, N. P., Chebotarev, A. N., Alekhin, V. I., Midian, S. A.: Population cytogenetic investigation of newborns in Moscow. Humangenetik 22, 139 (1974)
Boue, J., Boue, A., Lazar: The epidemiology of human spontaneous abortions with chromosomal anomalies. In: The biology pathology of aging gametes (ed. R. G. Blandan), p. 317. Basel: Karger 1974
Carr, D. H.: Chromosome anomalies as a cause of spontaneous abortion. Amer. J. Obstet. Gynec. 97, 283 (1967)
Chebotarev, A. N., Bochkov, N. P., Kirichenko, O. P.: Population cytogenetical studies of newborns with congenital malformations. Genetika (USSR) 9, 146 (1973)
Friedrich, U., Nielsen, J.: Chromosome studies in 5049 consecutive newborn children. Clin. Genet. 4, 333 (1973)
Gerald, P. S., Walzer, S.: Chromosome studies of normal newborn infants. In: Human population cytogenetics. Pfizer Medical Monographs No. 5 (eds. P. A. Jacobs, W. H. Price, P. Law), p. 143. Edinburgh: Edinburgh University Press 1970
Golovachev, G. D., Macarova, J. M., Shizinkina, L. N.: Numerical anomalies of X-chromosome among perinatally died children. Estimation of anomalies frequency by sex chromatin. Genetica (USSR) 10, 169 (1974)
Hamerton, J. L., Ray, M., Abbot, J., Williamson, C., Ducasse, G. S.: Chromosome studies in a neonatal populations. Canad. med. Ass. J. 106, 776 (1972)
Hungerford, D. A.: Leukocytes culture from small inocula of whole blood and the preparation of metaphase chromosomes treatment with hypotonic KCl. Stain Technol. 40, 333 (1965)
Jacobs, P. A., Melville, M., Ratckliffe, S., Keay, A., Syme, Y.: A cytogenetic survey of 11 680 newborn infants. Ann. hum. Genet. 37, 359 (1974)
Kuleshov, N. P., Midian, S. A., Chebotarev, A. N.: Chromosome abnormalities in premature babies. Genetica (USSR) (in press, 1975)
Kuliev, A. M.: Cytogenetic investigation of spontaneous abortions. Humangenetik 12, 275 (1971)
Machin, G. A., Crolla, J. A.: Chromosome constitution of 500 infants dying during the perinatal period. Humangenetik 23, 183 (1974)
Maclean, N., Harden, D. G., Court Brown, W. M., Bond, J., Mantle, D. J.: Sex chromosome abnormalities in newborn babies. Lancet 1964 I, 286
McMarden, P., Smith, D. W., McDonald, M. Y.: Congenital anomalies in the newborn infant, including minor variations. J. Pediat. 64, 357 (1964)
Lubs, H. A., Ruddle, F. H.: Chromosomal abnormalities in the human population: estimation of rates on New Haven newborn study. Science 169, 495 (1970)
Robinson, A.: Neonatal deaths and sex chromosome anomalies. Lancet 1974 I, 1223
Stewart, A. L., Keay, A. Y., Jacobs, P. A., Melville, M. M.: A chromosome survey of unselected live born children with congenital abnormalities. J. Pediat. 74, 449 (1969)
Sutherland, G. R., Bauld, R., Bain, A. D.: Chromosome abnormality and perinatal death. Lancet 1974, 752
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Kuleshov, N.P. Chromosome anomalies of infants dying during the perinatal period and premature newborn. Hum Genet 31, 151–160 (1976). https://doi.org/10.1007/BF00296143
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DOI: https://doi.org/10.1007/BF00296143