Abstract
Bone mineral density (BMD) and bone mineral content (BMC) were measured in the femoral neck area, trochanteric area and Wards triangle, and in the distal radius of the left forearm before and after 1 year of endocrine treatment in 27 patients with prostatic cancer. Eleven of the patients were treated with orchidectomy and 16 with combined oral and intramuscular estrogens. The patients were free from metastases during the entire observation period. In the orchidectomized patients, BMD and BMC of the distal radius decreased significantly following treatment, whereas no changes were observed in the estrogen-treated patients. These preliminary results demonstrate that estrogens may protect bone in male subjects also and may merit further investigations on larger groups of patients.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Clarke NW, McClure J, George NJ (1991) Preferential preservation of bone mineralization by LHRH agonists in the treatment of metastatic prostate cancer. Eur Urol 19:114–117
Goldray D, Weisman Y, Jaccard N, Merdler C, Chen J, Matzkin H (1993) Decreased bone density in elderly men treated with the gonadotropin-releasing hormone agonist Decapeptyl (D-Trp6-GnRH). J Clin Endocrinol Metab 76:288–290
Eriksson SAV, Widhe TL (1988) Bone mass in women with hip fracture. Acta Orthop Scand 59:19–23
Eriksson A, Carlström K (1988) Prognostic value of serum hormone concentrations in prostatic cancer. Prostate 13:249–256
Jönsson G, Olsson AM, Luttrop W, Cekan Z, Purvis K, Diczfalusy E (1975) Treatment of prostatic carcinoma with various types of estrogen derivatives. Vit Horm 33:351–376
Stege R, Eriksson A, Henriksson P, Carlström K (1987) Orchidectomy or estrogen treatment in prostatic cancer: effects on serum levels of adrenal androgens and related steroids. Int J Androl 10:581–587
Brody S, Carlström K, Lagrelius A, Lunell N-O, Möllerström G (1982) Adrenocortical steroids, bone mineral content and endometrial condition in postmenopausal women. Maturitas 4:113–122
Nordin BEC, Robertson A, Seamark RF, Bridges A, Philcox JC, Need AG, Horowitz M, Morris HA, Deam S (1985) The relation between calcium absorption, serum dehydroepiandrosterone, and vertebral mineral density in postmenopausal women. J Clin Endocrinol Metab 60:651–657
Markiewicz L, Gurpide E (1988) C19 adrenal steroids enhance prostaglanding F2 output by human endometrium in vitro. Am J Obstet Gynecol 159:500–504
Crilly RG, Francis RM, Nordin BEC (1981) Steroid hormones, ageing and bone. Clin Endocrinol Metab 10:115–139
Labrie F, Dupont A, Bélanger A, St-Arnaud R, Giguére M, Lacourciére Y, Emond J, Monfette G (1986) Treatment of prostate cancer with gonadotropin-releasing hormone agonists. Endocrine Rev 7:67–74
Hughes CL, Wall LL, Creasman WT (1991) Reproductive hormone levels in gynecologic oncology patients undergoing surgical castration after spontaneous menopause. Gynecol Oncol 40:42–45
Henriksson P, Edhag O (1986) Orchidectomy versus estrogen for prostatic cancer: cardiovascular effect. Br Med J 293: 41415.3
Stege R, Carlström K, Collste L, Eriksson A, Henriksson P, Pousette Å (1988) Single drug polyestradiol phosphate therapy in prostatic cancer. Am J Clin Oncol 11(suppl 2):5101–5103
Henriksson P, Blombäck M, Eriksson A, Stege R, Carlström K (1990) Effects of parenteral oestrogen on the coagulation system in patients with prostatic carcinoma. Br J Urol 65:282–285
Stege R, Carlström K, Collste L, Eriksson A, Henriksson P, Pousette Å, von Schoultz B (1989) Single drug parenteral estrogen treatment in prostatic cancer: a study of different initial and maintenance dose regimens. Prostate 14:183–188
Stege R, Carlström K, Henriksson P (1991) Parenteral oestrogen seems to be a cardiovascular safe therapy for patients with prostatic cancer (abstract). Scand J Urol Nephrol (suppl 135):56
Carlström K, Stege R, Henriksson P, Pousette Å (1994) Effects of endocrine treatment on bone mineral markers in patients with prostatic cancer (CAP) (abstract). Scand J Urol Nephrol (suppl) 161:28–29
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Eriksson, S., Eriksson, A., Stege, R. et al. Bone mineral density in patients with prostatic cancer treated with orchidectomy and with estrogens. Calcif Tissue Int 57, 97–99 (1995). https://doi.org/10.1007/BF00298427
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00298427