Skip to main content
Log in

Quantitative ultrasound bone measurements: Normal values and comparison with bone mineral density by dual X-ray absorptiometry

  • Clinical Investigations
  • Published:
Calcified Tissue International Aims and scope Submit manuscript

Abstract

Normative data for qualitative ultrasound (QUS) measurements: speed of sound (SOS), broadband ultrasound attenuation (BUA), and stiffness were established in 118 healthy women aged 20–86 years and in 42 healthy men aged 22–76 years. The relations between age, weight, height, and QUS were studied. QUS measurements were negatively correlated with age in both sexes. In women, age was accepted as first factor (R2=0.39 for SOS, 0.35 for BUA, and 0.45 for stiffness, P<0.001); weight was accepted as second factor for BUA (R2=0.44, P<0.001). In men, age was the only significant parameter (R2=0.41 for SOS, 0.39 for BUA, 0.43 for stiffness, P<0.001). QUS measurements of the right and the left feet were highly correlated unless unilateral foot pathology such as algodystrophy was present. Significant correlations were found between QUS of the calcaneus and dual X-ray absorptiometry (DXA) of the lumbar spine (R=0.67, P<0.01 for SOS; R=0.57 P<0.02 for BUA; R=0.65, P<0.01 for stiffness).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Heaney RP (1989) Osteoporotic space: an hypothesis. Bone Miner 6:1–13

    Google Scholar 

  2. Ott SM (1993) When bone mass fails to predict bone failure. Calcif Tissue Int 53 (suppl 1):S7-S13

    Google Scholar 

  3. Schnitzler CM (1993) Bone quality: a detrminant for certain risk factors for bone fragility. Calcif Tissue Int 53 (suppl 1):S27-S31

    Google Scholar 

  4. Brandenburger GH (1993) Clinical determination of bone quality: Is ultrasound an answer? Calcif Tissue Int 53 (suppl 1):S151-S156

    Google Scholar 

  5. Resch H, Pietschmann P, Bernecker P, Krexner E, Willvonseder R (1990) Broadband ultrasound attenuation: a new diagnostic method in osteoporosis. A J R 155:825–828

    Google Scholar 

  6. Craven JD, Constantini MA, Greenfield MA (1973) Measurement of velocity of ultrasound in human cortical bone and its potential clinical importance. J Invest Radiol 8:72–77

    Google Scholar 

  7. Langton CM, Palmer SB, Porter RW (1984) The measurements of broadband ultrasound attenuation in cancellous bone. Eng Med 13:89–91

    Google Scholar 

  8. Ashman RB, Cowin SC, van Burskirk WC, Rice JC (1984) A continuous wave technique for the measurement of the elastic properties of cortical bone. J Biomechanics 17:349–361

    Google Scholar 

  9. Evans JA, Tavakoli MB (1990) Ultrasonic attenuation and velocity in bone. Phys Med Biol 35:1387–1396

    Google Scholar 

  10. Agren M, Karellas A, Leahey D, Marks S, Baran D (1991) Ultrasound attenuation of the calcaneus: a sensitive and specific discriminator of osteopenia in postmenopausal women. Calcif Tissue Int 48:240–244

    Google Scholar 

  11. Damilakis JE, Dretakis E, Gourtsoyiannis NC (1992) Ultrasound attenuation of the calcaneus in the female population: normative data. Calcif Tissue Int 51:180–183

    Google Scholar 

  12. Wapniarz M, Lehman R, Banik N, Radwan M, Klein K, Allolio B (1993) Apparent velocity of ultrasound (AVU) at the patella in comparison to bone mineral density at the lumbar spine in normal males and females. Bone Miner 23:243–252

    Google Scholar 

  13. Heaney RP, Avioli LV, Chesnut III CH, Lappe J, Recker RR, Brandenburger GH (1989) Osteoporotic bone fragility. Detection by ultrasound transmission velocity. JAMA 261:2986–2990

    Google Scholar 

  14. Fredfeldt KE (1986) Sound velocity in the middle phalanges of the human hand. Acta Radiol Diag 1:27.1

    Google Scholar 

  15. Miller CG, Herd RJM, Ramaligan T, Fogelman I, Blake GM (1993) Ultrasonic velocity measurements through the calcaneus: Which velocity should be measured? Osteoporosis Int 3:31–35

    Google Scholar 

  16. Kotzki PO, Buyck D, Leroux JL, Thomas E, Rossi M, Blotman F (1993) Measurement of the bone mineral density of the calcaneus as an indication of vertebral fracture in women with lumbar osteoarthritis. Br J Radiol 66:55–60

    Google Scholar 

  17. Jones PRM, Hardman AE, Hudson A, Norgan NG (1991) Influence of brisk walking on the broadband ultrasonic attenuation of the calcaneus in previously sedentary women aged 30–61 years. Calcif Tissue Int 49:112–115

    Google Scholar 

  18. Baran DT, Kelly AM, Kerellas A, Gionet M, Price M, Leahey D, Steuterman S, McSherry B, Roche J (1988) Ultrasound attenuation of the calcaneus in women with osteoporosis and hip fractures. Calcif Tissue Int 43:138–142

    Google Scholar 

  19. Antich PP, Pak CYC, Gonzales J, Anderson J, Sakhaee K, Rubin C (1993) Measurement of intrinsic bone quality in vivo by reflection ultrasound: correction of impaired quality with slowrelease sodium fluoride and calcium citrate. J Bone Miner Res 8:301–311

    Google Scholar 

  20. Pacifici R, Rupich R, Vered I, Visscher KC, Griffin M, Susman N, Avioli LV (1988) Dual energy radiography: preliminary comparative study. Calcif Tissue Int 13:189–191

    Google Scholar 

  21. Lees B, Stevenson JC (1993) Preliminary evaluation of a new ultrasound bone densitometer. Calcif Tissue Int 53:149–152

    Google Scholar 

  22. Rossman P, Zagzebski J, Mesina C, Sorenson J, Mazess R (1991) Comparison of speed of sound and ultrasound attenuation in the os calcis to bone density of the radius, femur, and lumbar spine. Clin Phys Physiol Meas 10:353–360

    Google Scholar 

  23. Truscott JG, Simpson M, Stewart SP, Milner R, Westmacott CF, Oldroyd B, Evans JA, Horsman A, Langton CM, Smith MA (1992) Bone ultrasonic attenuation in women: reproducibility, normal variation, and comparison with photon absorptiomctry. Clin Phys Physiol Meas 13:29–36

    Google Scholar 

  24. Herd RJM, Blake GM, Ramalingam T, Miller CG, Ryan PJ, Fogelman I (1993) Measurements of postmenopausal bone loss with a new contact ultrasound system. Calcif Tissue Int 53:153–157

    Google Scholar 

  25. Riggs BL, Wahner MW, Dunn WL, Mazess RB, Offord KP, Melton LJ III (1981) Differential changes in bone mineral density of the appendicular skeleton with aging: relationship to spinal osteoporosis. J Clin Invest 67:328–335

    Google Scholar 

  26. Herd RJM, Blake GM, Miller CG, Parker JC, Fogelman I (1994) The ultrasonic assessment of osteopenia as defined by dual X-ray absorptiometry. Br J Radiol 67:631–635

    Google Scholar 

  27. Schott AM, Hans D, Somay-Rendu E, Delmas PD, Meunier PJ (1993) Ultrasound measurements of os calcis: precision and agerelated changes in a normal female population. Osteoporosis Int 3:249–254

    Google Scholar 

  28. Mazzess R, Trempe J, Genske T, Wiener S (1992) Ultrasound of the os calcis, Proceedings of Ultrasonic Assessment of Bone II, Bath, England

  29. Mautalen C, Gonzales D, Circosta AM (1993) Ultrasonic assessment of bone in normal and osteoporotic women (abstract A144). Proceedings Conference on Osteoporosis, Hong Kong

  30. Waud CE, Lew R, Baran DT (1992) The relationship between ultrasound and densitometric measurements of bone mass at the calcaneus in women. Calcif Tissue Int 51:415–418

    Google Scholar 

  31. Kotzki PO, Buyck D, Hans D, Thomas E, Bonnel F, Favier F, Meunier PJ, Rossi M (1994) Influence of fat on ultrasound measurements of the os calcis. Calcif Tissue Int 5′:91–95

    Google Scholar 

  32. McCloskey EV, Murray SA, Charlesworth D, Miller C, Fordham J, Clifford K, Atkins R, Kanis JA (1990) Assessment of broadband ultrasound attenuation in the os calcis in vitro. Clin Sci 78:221–225

    Google Scholar 

  33. Massie A, Reid DM, Porter RW (1993) Screening for osteoporosis: comparison between dual energy X-ray absorptiometry and broadband ultrasound attenuation in 1000 perimenopausal women. Osteoporosis Int 3:107–110

    Google Scholar 

  34. Martin P, Verhas M, Als C, Geerts L, Paternot J, Bergmann P (1993) Influence of patient's weight on dual-photon absorptiometry and dual-energy X-ray absorptiometry measurements of bone mineral density. Osteoporosis Int 3:198–203

    Google Scholar 

  35. Young H, Howey S, Purdie DW (1993) Broadband ultrasound attenuation compared with dual-energy X-ray absorptiometry in screening for postmenopausal low bone density. Osteoporosis Int 3:160–164

    Google Scholar 

  36. McCloskey EV, Murray SA, Miller C, Charlesworth D, Tindale W, O'Doherty DP, Bickerstaff DR, Hamdy NAT, Kanis JA (1990) Broadband ultrasound attenuation in the os calcis: relationship to bone mineral at other skeletal sites. Clin Sci 78:227–233

    Google Scholar 

  37. McKelvie ML, Fordham J, Clifford C, Palmer SB (1989) In vitro comparison of quantitative computer tomography and broadband attenuation of trabecular bone. Bone 10:101–104

    Google Scholar 

  38. Crépin G, Duquesnoy B, Juillot JP, Subtil D (1994) Evaluation de la densité osseuse du calcanéum par mesure de l'atténuation des ultrasons chez les femmes ménopausées. J Gynecol Obstet Biol Reprod 23:685–690

    Google Scholar 

  39. Glüer CC, Vahlensieck M, Faulkner KG, Engelke K, Black D, Genant HK (1992) Site-matched calcaneal measurements of broadband ultrasound attenuation and single X-ray absorptiometry: Do they measure different skeletal properties? J Bone Miner Res 7:1071–1079

    Google Scholar 

  40. Salamone LM, Krall EA, Harris S, Dawson-Hughes B (1994) Comparison of broadband ultrasound attenuation to single X-ray absorptiometry measurements at the calcaneus in postmenopausal women. Calcif Tissue Int 54:87–90

    Google Scholar 

  41. Faulkner KG, McClung MR, Coleman LJ, Kingston-Sandahl E (1994) Quantitative ultrasound of the heel: correlation with densitometric measurements at different skeletal sites. Osteoporosis Int 4:42–47

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Moris, M., Peretz, A., Tjeka, R. et al. Quantitative ultrasound bone measurements: Normal values and comparison with bone mineral density by dual X-ray absorptiometry. Calcif Tissue Int 57, 6–10 (1995). https://doi.org/10.1007/BF00298988

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00298988

Key words

Navigation